دورية أكاديمية
Carotid Artery Wall Echogenicity Measured by Gray Scale Median of the Intima-Media Complex From Childhood to Young Adulthood.
| العنوان: | Carotid Artery Wall Echogenicity Measured by Gray Scale Median of the Intima-Media Complex From Childhood to Young Adulthood. |
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| المؤلفون: | Guo F; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Chen X; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Niu Z; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Karim R; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Gauderman WJ; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., McConnell R; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Yan M; Atherosclerosis Research Unit University of Southern California Los Angeles CA USA., Whitfield L; Atherosclerosis Research Unit University of Southern California Los Angeles CA USA., Li Y; Atherosclerosis Research Unit University of Southern California Los Angeles CA USA., Bastain TM; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Breton CV; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA., Hodis HN; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA.; Atherosclerosis Research Unit University of Southern California Los Angeles CA USA., Farzan SF; Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles CA USA. |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 Aug 06; Vol. 13 (15), pp. e034821. Date of Electronic Publication: 2024 Aug 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Carotid Intima-Media Thickness* , Carotid Artery Diseases*/diagnostic imaging , Carotid Artery Diseases*/epidemiology , Carotid Artery Diseases*/physiopathology , Carotid Arteries*/diagnostic imaging , Carotid Arteries*/physiopathology, Humans ; Female ; Male ; Child ; Longitudinal Studies ; Young Adult ; Risk Factors ; Adolescent ; California/epidemiology ; Age Factors ; Blood Pressure/physiology ; Adult ; Predictive Value of Tests |
| مستخلص: | Background: Echogenicity of the carotid arterial wall, measured by gray scale median of the intima-media complex (IM-GSM), is a novel subclinical atherosclerosis marker with lower values indicating greater lipid deposition. Our longitudinal study investigated IM-GSM from childhood to adulthood and its associated risk factors. Methods and Results: A total of 240 participants from the Southern California CHS (Children's Health Study) underwent carotid artery ultrasounds in 2008 (mean age±SD): (11.2±0.6 years), and again around 2022 (24.2±1.6 years) to assess IM-GSM, carotid artery intima-media thickness, and carotid artery distensibility. Questionnaires and anthropometric and blood pressure measurements were completed by participants at both times. Mean and SD of IM-GSM were 108.2±24.6 in childhood and 75.6±15.8 in adulthood. Each 1-year increase in age was associated with -2.52 change in IM-GSM (95% CI, -2.76 to -2.27). Childhood and adulthood IM-GSMs were highly correlated (β=0.13 [95% CI, 0.05-0.22]). In childhood, Hispanic ethnicity, lower parental education levels and prenatal father smoking were significantly associated with lower IM-GSM. In adulthood, higher systolic blood pressure, carotid artery intima-media thickness, hypertension, and lower distensibility were significantly associated with lower IM-GSM. Weight status exhibited a consistent association with both childhood and adulthood IM-GSM. During the transition from childhood to adulthood, individuals who shifted from normal weight to overweight/obese or normal blood pressure to hypertension or experienced an increase in carotid artery intima-media thickness displayed lower levels of IM-GSM in adulthood. Conclusions: IM-GSM decreases with age. Maintaining healthy weight and blood pressure levels in children could potentially aid in preventing subclinical atherosclerosis. |
| فهرسة مساهمة: | Keywords: IM‐GSM; carotid artery wall echogenicity; children; gray scale median of the intima‐median complex; subclinical atherosclerosis |
| تواريخ الأحداث: | Date Created: 20240805 Date Completed: 20240806 Latest Revision: 20240806 |
| رمز التحديث: | 20240806 |
| DOI: | 10.1161/JAHA.124.034821 |
| PMID: | 39101497 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-9980 |
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| DOI: | 10.1161/JAHA.124.034821 |