دورية أكاديمية
Tetrahydroisoquinoline reduces angiogenesis by interacting myeloma cells with HUVECs mediated by extracellular vesicles.
العنوان: | Tetrahydroisoquinoline reduces angiogenesis by interacting myeloma cells with HUVECs mediated by extracellular vesicles. |
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المؤلفون: | Kooshari A; Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 14155-5983, Iran., Shahriyary F; Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 14155-5983, Iran., Shahidi M; Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 14155-5983, Iran. Shahidi.m@iums.ac.ir., Vafajoo M; Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 14155-5983, Iran., Amirzargar MR; Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 14155-5983, Iran. |
المصدر: | Medical oncology (Northwood, London, England) [Med Oncol] 2024 Aug 05; Vol. 41 (9), pp. 217. Date of Electronic Publication: 2024 Aug 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York : Springer Original Publication: Northwood, Middlesex, England : Science and Technology Letters, c1994- |
مواضيع طبية MeSH: | Human Umbilical Vein Endothelial Cells*/drug effects , Human Umbilical Vein Endothelial Cells*/metabolism , Multiple Myeloma*/pathology , Multiple Myeloma*/drug therapy , Multiple Myeloma*/metabolism , Extracellular Vesicles*/metabolism , Extracellular Vesicles*/drug effects , Neovascularization, Pathologic*/drug therapy , Neovascularization, Pathologic*/pathology , Neovascularization, Pathologic*/metabolism , Tetrahydroisoquinolines*/pharmacology , Cell Movement*/drug effects, Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coculture Techniques ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis |
مستخلص: | Multiple myeloma (MM) is a neoplastic condition resulting from the uncontrolled expansion of B-cell-derived plasma cells. The importance of angiogenesis in MM development has also been demonstrated. Extracellular vesicles (EVs) have vital functions in interactions between neighboring cells, such as angiogenesis. The objective of this in vitro study was to examine the transfection and angiogenesis effects of MM-EVs on endothelial cells (ECs) upon treatment with Tetrahydroisoquinoline (THIQ) as a bioactive organic compound derivative from isoquinoline. Following treatment of multiple myeloma cells (U266) with THIQ, MM-EVs were harvested and transmigrated to human umbilical vein endothelial cells (HUVEC) in a co-culture model. EVs transmigration was traced by flow cytometry. Correspondingly, the expression of angiogenic genes and/or proteins in U266 cells and HUVECs was measured by RT-PCR and ELISA methods. Likewise, the proliferation and migration of HUVECs treated with THIQ-treated MM-EVs were visualized and estimated by performing both tube formation and scratch wound healing methods. Surprisingly, the anti-angiogenic effect of THIQ-treated MM-EVs was evident by the decreased expression of CD34, VEGFR2, and IL-6 at the mRNA and/or protein levels after internalization of MM-EVs in HUVEC. Finally, tube formation and scratch wound healing experiments showed inhibition of HUVEC cell proliferation and migration by THIQ-treated MM-EVs compared to control MM-EVs. MM-EVs derived from THIQ-treated myeloma cells (U266) inhibited angiogenesis in HUVECs. This phenomenon is coordinated by the internalized THIQ-treated MM-EVs in HUVECs, and ultimately the reduction of angiogenic factors and inhibition of tube formation and scratch wound healing. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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معلومات مُعتمدة: | 99-3-5-19468 Iran University of Medical Sciences |
فهرسة مساهمة: | Keywords: Angiogenesis; Extracellular vesicles (EVs); IL-6; Multiple myeloma (MM); Tetrahydroisoquinoline (THIQ); Vascular endothelial growth factor receptor 2 (VEGFR-2) |
المشرفين على المادة: | 0 (Tetrahydroisoquinolines) 0 (Angiogenesis Inhibitors) |
تواريخ الأحداث: | Date Created: 20240805 Date Completed: 20240805 Latest Revision: 20240805 |
رمز التحديث: | 20240805 |
DOI: | 10.1007/s12032-024-02465-8 |
PMID: | 39102060 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1559-131X |
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DOI: | 10.1007/s12032-024-02465-8 |