دورية أكاديمية
أعرض في EDS

Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism.

التفاصيل البيبلوغرافية
العنوان: Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism.
المؤلفون: Louie AY; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Drnevich J; Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Johnson JL; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Woodard M; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Kukekova AV; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Johnson RW; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Steelman AJ; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
المصدر: IScience [iScience] 2024 Jul 05; Vol. 27 (8), pp. 110464. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype following cuprizone-induced demyelination that resulted in delayed OL maturation and remyelination in the prefrontal cortex. Furthermore, we assessed cellular metabolism ex vivo , and found that infection altered brain OL and microglia metabolism in a manner that opposed the metabolic profile induced by remyelination. Specifically, infection increased glycolytic capacity of OLs and microglia, an effect that was recapitulated by lipopolysaccharide (LPS) stimulation of mixed glia cultures. In contrast, mitochondrial dependence was increased in OLs during remyelination, which was similarly observed in OLs of myelinating P14 mice compared to adult and aged mice. Collectively, our data indicate that respiratory viral infection is capable of suppressing remyelination, and suggest that metabolic dysfunction of OLs is implicated in remyelination impairment.
Competing Interests: The authors declare no competing interests.
(© 2024 The Author(s).)
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معلومات مُعتمدة: R21 NS121741 United States NS NINDS NIH HHS; R35 GM144276 United States GM NIGMS NIH HHS; RF1 AG059622 United States AG NIA NIH HHS; T32 EB019944 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: cellular neuroscience; molecular neuroscience; neuroscience; omics; transcriptomics
تواريخ الأحداث: Date Created: 20240806 Latest Revision: 20240830
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC11298649
DOI: 10.1016/j.isci.2024.110464
PMID: 39104416
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2024.110464