دورية أكاديمية
Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians.
| العنوان: | Association of paraoxonase-1 (Q192R) gene polymorphism with coronary artery spasm during cardiac catheterisation in Egyptians. |
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| المؤلفون: | Abdelaziz TA; Department of Cardiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Mesbah NM; Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Abo-Elmatty DM; Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., El-Sabbagh FO; Department of Biochemistry, Faculty of Pharmacy, Sinai University (Kantra Campus), El-Arish, Egypt. |
| المصدر: | Archives of physiology and biochemistry [Arch Physiol Biochem] 2024 Aug 06, pp. 1-7. Date of Electronic Publication: 2024 Aug 06. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9510153 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4160 (Electronic) Linking ISSN: 13813455 NLM ISO Abbreviation: Arch Physiol Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995- |
| مستخلص: | Background: Coronary artery spasm is among the etiology of myocardial infarction. Oxidative stress is involved in the pathogenesis of coronary artery spasm (CAS). Paraoxonase-1 (PON1) is an HDL-bound antioxidant enzyme that protects LDL from oxidative modification. Oxidative-stress-related genetic factors and certain polymorphisms in the paraoxonase 1 gene might influence the pathogenesis of CAS. We aimed to investigate the association between PON1 gene polymorphism and its enzymatic activity and coronary artery spasm during cardiac catheterization. Methods and Results: The study population was 150 patients who underwent elective coronary angiography. Subjects were genotyped to the Q192R polymorphism (rs662) on the PON1 gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and PON1 activity was quantitatively analyzed by enzyme linked immunosorbent assay. Results showed that the subjects carrying the RR genotype and R allele were significantly more likely to develop coronary artery spasm (OR=4.2, 2.03, P < 0.006, P ˂0.02, respectively). Moreover, serum PON1 levels were significantly decreased ( P ˂0.001) in the CAS group. RR genotype of PON1 Q192R polymorphism, Tc, LDLc, TG, catheter size, and paroxonase-1 serum level are independent predictors of coronary spasm. Conclusion: We conclude that the PON1 (rs662) gene polymorphism is associated with CAS during cardiac catheterization in Egyptians. The PON1-192R allele and lower serum enzyme concentration may play an important role in coronary spasm. |
| فهرسة مساهمة: | Keywords: Coronary artery spasm (CAS); PON1; Q192R polymorphism |
| تواريخ الأحداث: | Date Created: 20240806 Latest Revision: 20240806 |
| رمز التحديث: | 20240806 |
| DOI: | 10.1080/13813455.2024.2387691 |
| PMID: | 39105458 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-4160 |
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| DOI: | 10.1080/13813455.2024.2387691 |