دورية أكاديمية
أعرض في EDS

Improving COVID-19 contact tracing and testing of exposed individuals in Cameroon using digital health technology: a cluster randomised trial.

التفاصيل البيبلوغرافية
العنوان: Improving COVID-19 contact tracing and testing of exposed individuals in Cameroon using digital health technology: a cluster randomised trial.
المؤلفون: Tchakounte Youngui B; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Mambo A; Ministry of Public Health, Littoral Regional Delegation for Public Health, Douala, Cameroon., Machekano R; Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA., Kana R; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Epée E; Ministry of Public Health, Public Health Emergency Operations Center, Yaoundé, Cameroon., Tenkeu SZ; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Tsigaing PN; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Ndongo MLA; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Njoukam CM; Ministry of Public Health, Littoral Regional Delegation for Public Health, Douala, Cameroon., Bichara L; Ministry of Public Health, Littoral Regional Delegation for Public Health, Douala, Cameroon., Katcho TD; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Mbunka MA; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Longla TA; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Simo L; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Kouatchouang AV; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Tchendjou P; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon., Tiam A; Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.; Department of Epidemiology, The George Washington University, Milken Institute School of Public Health, Washington, DC, USA., Guay L; Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.; Department of Epidemiology, The George Washington University, Milken Institute School of Public Health, Washington, DC, USA., Suleiman K; FIND, Switzerland., Akinwusi O; FIND, Switzerland., Kadam R; FIND, Switzerland., Akugizibwe P; FIND, Switzerland., Songane M; Elizabeth Glaser Pediatric AIDS Foundation, Maputo, Mozambique., Woelk G; Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA., Tchounga BK; Elizabeth Glaser Pediatric AIDS Foundation, Yaoundé, Cameroon.
مؤلفون مشاركون: DTECT study group
المصدر: EClinicalMedicine [EClinicalMedicine] 2024 Jul 13; Vol. 74, pp. 102730. Date of Electronic Publication: 2024 Jul 13 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: The Lancet Country of Publication: England NLM ID: 101733727 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5370 (Electronic) Linking ISSN: 25895370 NLM ISO Abbreviation: EClinicalMedicine Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : The Lancet, [2018]-
مستخلص: Background: Contact tracing was described as a key strategy to contribute to controlling the spread of severe acute respiratory syndrome of Coronavirus 2 (SARS-CoV-2) but implementing it can be a challenge. Digitalisation of contact tracing is among the proposed solutions being explored in sub-Saharan African settings. We assessed the effectiveness of a digital tool to expand SARS-CoV-2 testing in exposed individuals in Cameroon.
Methods: We conducted a cluster-randomised (1:1) trial in eight health districts, including 22 facilities and SARS-CoV-2 testing units, randomly assigned to a digital (intervention) or standard (control) contact tracing approach. The intervention consisted of a contact tracing module added to the digital platform "Mamal PRO" used for monitoring and coordination of Coronavirus Disease 2019 pandemic response in Cameroon. The primary outcome was the proportion of contacts declared by SAR-CoV-2 index patients who were successfully traced and tested for SARS-CoV-2 evaluated with a Poisson regression model with cluster adjustment. This study is registered with ClinicalTrials.gov (NCT05684887).
Findings: Between October 18, 2022, and March 31, 2023, we enrolled 164 index patients in the intervention arm and 149 in the control arm, who identified 854 and 849 contacts, respectively. In the intervention arm, 93.8% (801/854) of identified contacts were successfully reached by the tracing unit versus 54.5% (463/849) in the control arm. The intervention significantly increased the likelihood of successfully tracing contacts (adjusted relative risks (RR) 1.72 [95% CI: 1.00-2.95], p = 0.049). The median (interquartile range, IQR) time to successfully tracing contacts was 0 days [IQR: 0, 1] in the intervention and 1 day [IQR: 0, 2] in the control arm. In the intervention arm, 21.3% (182/854) of identified contacts received SARS-CoV-2 testing compared to 14.5% (123/849) in the control arm (adjusted RR 1.47 [95% CI: 0.44-4.90], p = 0.530).
Interpretation: Digitalising the contact tracing process improved exposure notification and facilitated the tracing of a greater number of contacts of individuals infected with SARS-CoV-2 in resource-limited settings.
Funding: The study was funded by FIND, United Kingdom (FCDO 40105983), Switzerland (81066910), Netherlands (SDD 4000004160), Canada (DFATD 7429348), The Kingdom of Saudi Arabia (FIND-ACT-A DX PARTNERSHIP 20.08.2020), The Rockefeller Foundation (2020 HTH 059), Germany (BMZ Covid-19 Diagnostic and Surveillance Response 27.07.2021), Australia (DFAT 76442), Kuwait (M239/2020), The Government of Portugal and Partners (ANF, BCP, CGF, APIFARMA) and The BlackRock Foundation (Grant Agreement as of April 20, 2022).
Competing Interests: BKT has received support from FIND (through funding for the AFCON grant paid to his institution) to participate to a meeting on operational research in Kigali and the CPHIA conference. All other authors declared no competing interests to disclose.
(© 2024 The Author(s).)
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فهرسة مساهمة: Investigator: AD Ndjomo Mba; MN Nanga Dampand; RN Azi; CN Nelle Jembe; RL Djouota; T Messomo; JL Bell Mathias; JL Mbengue; MG Mbody; ET Tchouatcha; JL Nekame Guedem; FD Messina Maga; AM Ngeukoue Kamdoum; AK Nechi; JM Akono; PH Tamssa; VA Goretti Mvong; FG Zogni; MM Tekou Makamte; PB Tawambe; L Ewane; CR Mbengue Moukouri; HM Makembe; CM Nyate; MN Mengong Bitounou; GT Mendjiegoue; MM Fomo; A Nwatsok A Bessong; SF Nguefack; NS Nyaloumbe Abedine; M Njiken; FT Zangue; IO Benga Mve; AT Kengue; AV Christian Kingue; N Aissatou; ET Lako; OA Nta; Z Lawane; GD Dada; GC Yemy; TE Mballa; CT Querie; B Mebong; J Wa; MM Biloa Awono; WG Wele; J Kenko; SL Guimbang A Ireke; NN Epoune; AJ Ngadje Tchakounte; AM Azangue; FA Bika Baring; AN Vessah; GN Ngoh; FJ Nyato; V Ngogang; SD Fankou; RE Aboubakar; PD Ngo Banin; SB Dipoko
Keywords: COVID-19; Cluster randomised trial; Contact tracing; Digital health; m-Health
سلسلة جزيئية: ClinicalTrials.gov NCT05684887
تواريخ الأحداث: Date Created: 20240807 Latest Revision: 20240808
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC11300906
DOI: 10.1016/j.eclinm.2024.102730
PMID: 39109192
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-5370
DOI:10.1016/j.eclinm.2024.102730