دورية أكاديمية
Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial.
| العنوان: | Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial. |
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| المؤلفون: | Gamne R; Department Kayachikitsa, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India., Misar S; Department Kayachikitsa, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India., Rai M; Department Kayachikitsa, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. |
| المصدر: | F1000Research [F1000Res] 2024 Jun 17; Vol. 12, pp. 1577. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Comparative Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : F1000 Research Ltd |
| مواضيع طبية MeSH: | Sertraline*/therapeutic use , Celastrus* , Anxiety Disorders*/drug therapy, Humans ; Capsules ; Female ; Male ; Adult ; Treatment Outcome ; Plant Extracts/therapeutic use ; Randomized Controlled Trials as Topic ; Middle Aged |
| مستخلص: | Background: Generalized anxiety disorder (GAD) (Chittodvega) is one among many types of mental disorders explained in Ayurveda. It can be defined as a Chitta (mind) + Udvega (anxiety)= Chittodvega - Anxious status of a mind. Celastrus paniculatus also known as Jyotishmati. stimulates and improves the digestive fire and metabolism at a cellular level ( Jatharagni and Majja dhatwagni). It can be correlated to GAD. GAD is characterized by feelings of threat, restlessness, irritability, sleep disturbance, and tension, and symptoms such as palpitations, dry mouth, and sweating. It affects women more frequently than men and prevalence rates are high in midlife (prevalence in females over age 35: 10%) and older subjects. In modern medicine the first-line psychological and pharmaceutical treatments are selective serotonin reuptake inhibitors (SSRIs) like sertraline (SNRIs). Aim and Objectives: To evaluate the comparative efficacy of Jyotishmati versus sertraline in the management of Chittodvega. Methods: In this randomized active controlled double blind equivalence trial a total of 70 patients will be enrolled and divided into two equal groups. Patients between 20-50 years age of either gender having symptoms of Chittodvega and a Hamilton anxiety rating (HAM-A) scale score less than 24 (i.e., mild to moderate) will be selected for the study. In Group A, sertraline capsules 25 mg for first 7 days and then dose increased to 50 mg at bedtime for next 53 days and in Group B Jyotishmati Capsules 500 mg will be given twice a day after food with water for 60 days. Result and Observation: The patients will be assessed on the HAM-A scale, serum cortisol and WHO Quality of Life on day 0, 30, 60 and 90 and data will be analyzed using paired and unpaired t-tests for continuous variables and chi-square tests for categorical variables to evaluate whether treatments are equivalent. Trial Registration: CTRI No. REF/2023/07/069880 Date - 15/09/2023. Competing Interests: No competing interests were disclosed. (Copyright: © 2024 Gamne R et al.) |
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| فهرسة مساهمة: | Keywords: Celastrus paniculatus; Chittodvega; GAD; HAM-A Scale; Jyotishmati; Medhya; Sertralin |
| المشرفين على المادة: | QUC7NX6WMB (Sertraline) 0 (Capsules) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20240808 Date Completed: 20240808 Latest Revision: 20240829 |
| رمز التحديث: | 20240830 |
| مُعرف محوري في PubMed: | PMC11305454 |
| DOI: | 10.12688/f1000research.139473.2 |
| PMID: | 39114320 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2046-1402 |
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| DOI: | 10.12688/f1000research.139473.2 |