دورية أكاديمية
أعرض في EDS

A randomized controlled trial comparing tacrolimus versus hydrocortisone for the treatment of atopic dermatitis in children: new perspectives on interferon gamma-induced protein and growth-related oncogene-α.

التفاصيل البيبلوغرافية
العنوان: A randomized controlled trial comparing tacrolimus versus hydrocortisone for the treatment of atopic dermatitis in children: new perspectives on interferon gamma-induced protein and growth-related oncogene-α.
المؤلفون: Binsaleh AY; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Bahaa MM; Pharmacy Practice Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Elmasry TA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Elberri EI; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Kotkata FA; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt., El-Khateeb E; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Kamal M; Department of Clinical Pharmacy, Faculty of Pharmacy, Fayoum University, Faiyum, Egypt., El-Samongy MA; Department of Dermatology, Faculty of Medicine, Tanta University, Tanta, Egypt., Hamouda AO; Department of Biochemistry and Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Alghamdi AM; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Alrubia S; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Salahuddin MM; Department of Biochemistry and Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Eltantawy N; Department of Pharmacy Practice, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
المصدر: Frontiers in medicine [Front Med (Lausanne)] 2024 Jul 24; Vol. 11, pp. 1399305. Date of Electronic Publication: 2024 Jul 24 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]-
مستخلص: Introduction: Atopic dermatitis (AD) is a type of chronic inflammatory disorder that affects children.
Aim: To investigate whether hydrocortisone or tacrolimus could be more effective for treating AD in children.
Patients and Methods: This clinical randomized investigation included 100 children with AD who met the eligibility criteria. AD patients were recruited from Tanta University's Dermatology Department and divided into two groups ( n = 50)., For four months, group 1 (the hydrocortisone group) received topical hydrocortisone cream. Group 2 received topical tacrolimus for four months. A dermatologist evaluated the patients at the start and four months after the treatment had been initiated to measure serum concentrations of neutrophil chemoattractant growth-related oncogene-α (GRO-α), interferon gamma induced protein 10 (IP-10), tumor necrosis factor alpha (TNF-α), vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1). All patients were examined using the modified Eczema Area and Severity Index (mEASI) score.
Results: Tacrolimus group showed a significant reduction in serum levels of all measured biomarkers ( p < 0.05) when compared to its baseline and when compared to the hydrocortisone group. Both groups displayed a significant decline in mEASI score in comparison with their baseline values ( p < 0.05).
Conclusion: In children with AD, tacrolimus reduces inflammatory biomarkers better than hydrocortisone, suggesting its potential as a more effective treatment option.
Clinical Trial Registration: https://clinicaltrials.gov, identifier NCT05607901.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Binsaleh, Bahaa, Elmasry, Elberri, Kotkata, El-Khateeb, Kamal, El-samongy, Hamouda, Alghamdi, Alrubia, Salahuddin and Eltantawy.)
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فهرسة مساهمة: Keywords: GRO-α; atopic dermatitis; hydrocortisone; interferon gamma induced protein 10; tacrolimus
سلسلة جزيئية: ClinicalTrials.gov NCT05607901
تواريخ الأحداث: Date Created: 20240808 Latest Revision: 20240809
رمز التحديث: 20240809
مُعرف محوري في PubMed: PMC11303293
DOI: 10.3389/fmed.2024.1399305
PMID: 39114823
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-858X
DOI:10.3389/fmed.2024.1399305