دورية أكاديمية
أعرض في EDS

Sexual dimorphism of hypothalamic serotonin release during systemic inflammation: Role of endothelin-1.

التفاصيل البيبلوغرافية
العنوان: Sexual dimorphism of hypothalamic serotonin release during systemic inflammation: Role of endothelin-1.
المؤلفون: Costa RA; Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Brazil., Amatnecks JA; Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Brazil., de Oliveira Guaita G; Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Brazil., Stern CAJ; Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Brazil., Branco LGS; Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil., Zampronio AR; Department of Pharmacology, Biological Sciences Section, Federal University of Paraná, Brazil. Electronic address: aleksander@ufpr.br.
المصدر: Journal of neuroimmunology [J Neuroimmunol] 2024 Sep 15; Vol. 394, pp. 578427. Date of Electronic Publication: 2024 Aug 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981-
مواضيع طبية MeSH: Endothelin-1*/metabolism , Hypothalamus*/metabolism , Hypothalamus*/drug effects , Sex Characteristics* , Inflammation*/metabolism , Inflammation*/chemically induced , Serotonin*/metabolism , Piperidines*/pharmacology , Rats, Wistar*, Animals ; Male ; Female ; Rats ; Lipopolysaccharides/toxicity ; Oligopeptides/pharmacology ; Hydroxyindoleacetic Acid/metabolism ; Endothelin Receptor Antagonists/pharmacology ; Fever/metabolism ; Fever/chemically induced
مستخلص: The hypothalamus receives serotonergic projections from the raphe nucleus in a sex-specific manner. During systemic inflammation, hypothalamic levels of serotonin (5-hydroxytryptamine [5-HT]) decrease in male rats. The present study evaluated the involvement of endothelin-1 (ET-1) in the febrile response, hypolocomotion, and changes in hypothalamic 5-HT levels during systemic inflammation in male and female rats. An intraperitoneal injection of lipopolysaccharide (LPS) induced a febrile response and hypolocomotion in both male and female rats. However, although LPS reduced hypothalamic levels of 5-HT and its metabolite 5-hydroxyindol acetic acid (5-HIAA) in male rats, it increased these levels in female rats. An intracerebroventricular injection of the endothelin-B receptor antagonist BQ788 significantly reduced LPS-induced fever and hypolocomotion and changes in hypothalamic 5-HT and 5-HIAA levels in both male and female rats. The i.c.v. administration of ET-1 induced a significant fever and hypolocomotion, but reduced the hypothalamic levels of 5-HT and 5-HIAA in both males and females. These results suggest an important sexual dimorphism during systemic inflammation regarding the release of 5-HT in the hypothalamus. Moreover, ET-1 arises as an important mediator involved in the changes in hypothalamic 5-HT levels in both male and female rats.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Febrile response; Hypolocomotion; Hypothalamus; Lipopolysaccharide
المشرفين على المادة: 0 (Endothelin-1)
333DO1RDJY (Serotonin)
0 (Piperidines)
0 (Lipopolysaccharides)
44OLL8XEJ4 (BQ 788)
0 (Oligopeptides)
54-16-0 (Hydroxyindoleacetic Acid)
0 (Endothelin Receptor Antagonists)
تواريخ الأحداث: Date Created: 20240808 Date Completed: 20240828 Latest Revision: 20240904
رمز التحديث: 20240904
DOI: 10.1016/j.jneuroim.2024.578427
PMID: 39116522
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8421
DOI:10.1016/j.jneuroim.2024.578427