دورية أكاديمية
أعرض في EDS

Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging.

التفاصيل البيبلوغرافية
العنوان: Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging.
المؤلفون: Chen X; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Wang Y; Department of Molecular Endocrinology, Diabetes and Metabolism Institute, City of Hope Medical Center, Duarte, CA 91010, USA., Li H; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Deng Y; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Giang C; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Song A; Department of Molecular Endocrinology, Diabetes and Metabolism Institute, City of Hope Medical Center, Duarte, CA 91010, USA., Liu Y; Tongji University Cancer Center, School of Medicine, Tongji University, Shanghai 200092, China., Wang QA; Department of Molecular Endocrinology, Diabetes and Metabolism Institute, City of Hope Medical Center, Duarte, CA 91010, USA., Zhu Y; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
المصدر: Cells [Cells] 2024 Jul 23; Vol. 13 (15). Date of Electronic Publication: 2024 Jul 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Hyaluronic Acid*/metabolism , Cold Temperature* , Adipose Tissue, White*/metabolism , Adipose Tissue, White*/drug effects, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Adipose Tissue, Beige/metabolism ; Adipocytes, Beige/metabolism ; Adipocytes, Beige/drug effects ; Extracellular Matrix/metabolism ; Dioxoles/pharmacology ; Receptors, Adrenergic, beta-3/metabolism ; Adrenergic beta-3 Receptor Agonists/pharmacology
مستخلص: Adipose tissue beiging refers to the process by which beige adipocytes emerge in classical white adipose tissue depots. Beige adipocytes dissipate chemical energy and secrete adipokines, such as classical brown adipocytes, to improve systemic metabolism, which is beneficial for people with obesity and metabolic diseases. Cold exposure and β3-adrenergic receptor (AR) agonist treatment are two commonly used stimuli for increasing beige adipocytes in mice; however, their underlying biological processes are different. Transcriptional analysis of inguinal white adipose tissue (iWAT) has revealed that changes in extracellular matrix (ECM) pathway genes are specific to cold exposure. Hyaluronic acid (HA), a non-sulfated linear polysaccharide produced by nearly all cells, is one of the most common components of ECM. We found that cold exposure significantly increased iWAT HA levels, whereas the β3-AR agonist CL316,243 did not. Increasing HA levels in iWAT by Has2 overexpression significantly increases cold-induced adipose tissue beiging; in contrast, decreasing HA by Spam1 overexpression, which encodes a hyaluronidase that digests HA, significantly decreases cold-induced iWAT beiging. All these data implicate a role of HA in promoting adipose tissue beiging, which is unique to cold exposure. Given the failure of β3-AR agonists in clinical trials for obesity and metabolic diseases, increasing HA could serve as a new approach for recruiting more beige adipocytes to combat metabolic diseases.
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فهرسة مساهمة: Keywords: HAS2; PH20; cold-induced adipose tissue beiging; extracellular matrix; hyaluronan
المشرفين على المادة: 9004-61-9 (Hyaluronic Acid)
138908-40-4 (disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate)
0 (Dioxoles)
0 (Receptors, Adrenergic, beta-3)
0 (Adrenergic beta-3 Receptor Agonists)
تواريخ الأحداث: Date Created: 20240809 Date Completed: 20240809 Latest Revision: 20240811
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC11311271
DOI: 10.3390/cells13151233
PMID: 39120264
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells13151233