دورية أكاديمية
Development of poly (lactic-co-glycolic acid) (PLGA) based implants using hot melt extrusion (HME) for sustained release of drugs: The impacts of PLGA's material characteristics.
| العنوان: | Development of poly (lactic-co-glycolic acid) (PLGA) based implants using hot melt extrusion (HME) for sustained release of drugs: The impacts of PLGA's material characteristics. |
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| المؤلفون: | Yang F; Ashland Specialty Ingredients, Wilmington, DE, USA. Electronic address: fyyang@ashland.com., Stahnke R; Ashland Specialty Ingredients, Wilmington, DE, USA., Lawal K; Ashland Specialty Ingredients, Wilmington, DE, USA., Mahnen C; Ashland Specialty Ingredients, Wilmington, DE, USA., Duffy P; Ashland Specialty Ingredients, Wilmington, DE, USA., Xu S; Ashland Specialty Ingredients, Wilmington, DE, USA., Durig T; Ashland Specialty Ingredients, Wilmington, DE, USA. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2024 Sep 30; Vol. 663, pp. 124556. Date of Electronic Publication: 2024 Aug 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry , Drug Liberation* , Dexamethasone*/chemistry , Dexamethasone*/administration & dosage , Metformin*/chemistry , Metformin*/administration & dosage , Delayed-Action Preparations*/chemistry , Solubility* , Carbamazepine*/chemistry , Carbamazepine*/administration & dosage , Hot Melt Extrusion Technology*/methods, Drug Implants/chemistry ; Polyglycolic Acid/chemistry ; Drug Carriers/chemistry ; Hot Temperature ; Lactic Acid/chemistry |
| مستخلص: | Hot melt extrusion (HME) processed Poly (lactic-co-glycolic acid) (PLGA) implant is one of the commercialized drug delivery products, which has solid, well-designed shape and rigid structures that afford efficient locoregional drug delivery on the spot of interest for months. In general, there are a variety of material, processing, and physiological factors that impact the degradation rates of PLGA-based implants and concurrent drug release kinetics. The objective of this study was to investigate the impacts of PLGA's material characteristics on PLGA degradation and subsequent drug release behavior from the implants. Three model drugs (Dexamethasone, Carbamazepine, and Metformin hydrochloride) with different water solubility and property were formulated with different grades of PLGAs possessing distinct co-polymer ratios, molecular weights, end groups, and levels of residual monomer (high/Viatel TM and low/ Viatel TM Ultrapure). Physicochemical characterizations revealed that the plasticity of PLGA was inversely proportional to its molecular weight; moreover, the residual monomer could impose a plasticizing effect on PLGA, which increased its thermal plasticity and enhanced its thermal processability. Although the morphology and microstructure of the implants were affected by many factors, such as processing parameters, polymer and drug particle size and distribution, polymer properties and polymer-drug interactions, implants prepared with Viatel TM PLGA showed a smoother surface and a stronger PLGA-drug intimacy than the implants with Viatel TM Ultrapure PLGA, due to the higher plasticity of the Viatel TM PLGA. Subsequently, the implants with Viatel TM PLGA exhibited less burst release than implants with Viatel TM Ultrapure PLGA, however, their onset and progress of the lag and substantial release phases were shorter and faster than the Viatel TM Ultrapure PLGA-based implants, owing to the residual monomer accelerated the water diffusion and autocatalyzed PLGA hydrolysis. Even though the drug release profiles were also influenced by other factors, such as composition, drug properties and polymer-drug interaction, all three cases revealed that the residual monomer accelerated the swelling and degradation of PLGA and impaired the implant's integrity, which could negatively affect the subsequent drug release behavior and performance of the implants. These results provided insights to formulators on rational PLGA implant design and polymer selection. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Hot melt extrusion (HME); Implant; Poly (lactic-co-glycolic acid) (PLGA) |
| المشرفين على المادة: | 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) 7S5I7G3JQL (Dexamethasone) 9100L32L2N (Metformin) 0 (Delayed-Action Preparations) 33CM23913M (Carbamazepine) 0 (Drug Implants) 26009-03-0 (Polyglycolic Acid) 0 (Drug Carriers) 33X04XA5AT (Lactic Acid) |
| تواريخ الأحداث: | Date Created: 20240809 Date Completed: 20240831 Latest Revision: 20240831 |
| رمز التحديث: | 20240901 |
| DOI: | 10.1016/j.ijpharm.2024.124556 |
| PMID: | 39122196 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2024.124556 |