دورية أكاديمية
أعرض في EDS

Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion.
المؤلفون: Carvalho A; Universidade Estadual Do Piauí, Teresina, Brazil., da Luz Silva I; Universidade Estadual Do Piauí, Teresina, Brazil., da Cruz Neto PR; Universidade Estadual Do Piauí, Teresina, Brazil., Pokorny G; Instituto de Patologia da Coluna, São Paulo, Brazil. ghpokorny@gmail.com., Amaral R; Instituto de Patologia da Coluna, São Paulo, Brazil., Pratali R; Hospital Do Servidor Público Estadual, São Paulo, Brazil., Acácio R; Instituto de Ortopedia E Traumatologia de Joinville, Joinville, Brazil., Romeiro C; Instituto de Coluna E Ortopedia de Recife (InCore), Recife, Brazil., Magno MV; Universidade da Região de Joinville (UNIVILLE), Joinville, Brazil., Daher M; Centro de Reabilitação E Readaptação Dr. Henrique Santillo (CRER), Goiânia, Brazil., Herrero CFPS; Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil.
مؤلفون مشاركون: Brazilian Spine Study Group
المصدر: Neurosurgical review [Neurosurg Rev] 2024 Aug 10; Vol. 47 (1), pp. 416. Date of Electronic Publication: 2024 Aug 10.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Springer Berlin Heidelberg Country of Publication: Germany NLM ID: 7908181 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-2320 (Electronic) Linking ISSN: 03445607 NLM ISO Abbreviation: Neurosurg Rev Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Berlin Heidelberg
Original Publication: Berlin : Walter De Gruyter
مواضيع طبية MeSH: Tranexamic Acid*/therapeutic use , Scoliosis*/surgery , Spinal Fusion*/methods , Spinal Fusion*/adverse effects , Antifibrinolytic Agents*/therapeutic use , Blood Loss, Surgical*/prevention & control, Humans ; Female ; Male ; Adolescent ; Prospective Studies ; Adult ; Blood Transfusion/statistics & numerical data ; Treatment Outcome ; Postoperative Period ; Length of Stay ; Young Adult ; Postoperative Hemorrhage/epidemiology
مستخلص: Scoliosis is the most prevalent type of spinal deformity, with a 2-3% prevalence in the general population. Moreover, surgery for scoliotic deformity may result in severe blood loss and, consequently, the need for blood transfusions, thereby increasing surgical morbidity and the rate of complications. Several antifibrinolytic drugs, such as tranexamic acid, have been regarded as safe and effective options for reducing blood loss. Therefore, the present study aimed to analyse the effectiveness of this drug for controlling bleeding when used intraoperatively and in the first 48 h after surgery. A prospective randomized study of a cohort of patients included in a mass event for scoliosis treatment using PSF was performed. Twenty-eight patients were analysed and divided into two groups: 14 patients were selected for intraoperative and postoperative use of tranexamic acid (TXA), and the other 14 were selected only during the intraoperative period. The drainage bleeding rate, length of hospital stay, number of transfused blood units, and rate of adverse clinical effects were compared. All the patients involved had similar numbers of fusion levels addressed and similar scoliosis profiles. The postoperative bleeding rate through the drain did not significantly differ between the two groups (p > 0.05). There was no significant difference in the number of transfused blood units between the groups (p = 0.473); however, in absolute numbers, patients in the control group received more transfusions. The length of hospital stay was fairly similar between the groups, with no statistically significant difference. Furthermore, the groups had similar adverse effects (p = 0.440), with the exception of nausea and vomiting, which were twice as common in the TXA group postoperatively than in the control group. No significant differences were found in the use of TXA during the first 48 postoperative hours or in postoperative outcomes.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
References: Filho RVT, De Matos AG, Melo NC, Rabahi MF, Daher MT (2019) Genetic aspects of idiopathic escoliosis - a literature review. Coluna/Columna 18(3):236–239. https://doi.org/10.1590/S1808-185120191803212974. (PMID: 10.1590/S1808-185120191803212974)
Miller DJ, Cahill PJ, Vitale MG, Shah SA (2020) Posterior correction techniques for adolescent idiopathic scoliosis. J Am Acad Orthop Surg 28(9):E363–E373. https://doi.org/10.5435/JAAOS-D-18-00399. (PMID: 10.5435/JAAOS-D-18-0039931633657)
Shrestha IK, Ruan TY, Lin L et al (2021) The efficacy and safety of high-dose tranexamic acid in adolescent idiopathic scoliosis: a meta-analysis. J Orthop Surg Res 16(1):1–9. https://doi.org/10.1186/S13018-020-02158-8. (PMID: 10.1186/S13018-020-02158-8)
Fatima M, Ahmed A, Zaheer Z et al (2022) Efficacy and safety of tranexamic acid for reduction in blood transfusions in patients undergoing major non-cardiac surgeries: a systematic review and meta-analysis of randomized controlled trials. Blood 140(Supplement 1):5709–5710. https://doi.org/10.1182/BLOOD-2022-165405. (PMID: 10.1182/BLOOD-2022-165405)
Bosch P, Kenkre TS, Soliman D, Londino JA, Novak NE (2019) Comparison of the coagulation profile of adolescent idiopathic scoliosis patients undergoing posterior spinal fusion with and without tranexamic acid. Spine Deform 7(6):910–916. https://doi.org/10.1016/J.JSPD.2019.04.005. (PMID: 10.1016/J.JSPD.2019.04.00531732001)
McNicol ED, Tzortzopoulou A, Schumann R, Carr DB, Kalra A (2016) Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. The Cochrane database of systematic reviews, 9(9):CD006883. https://doi.org/10.1002/14651858.CD006883.pub3.
Rahmani R, Singleton A, Fulton Z, Pederson JM, Andreshak T (2021) Tranexamic acid dosing strategies and blood loss reduction in multilevel spine surgery: A systematic review and network meta-analysis: Tranexamic acid for multilevel spine surgery. N Am Spine Soc J 8:100086. https://doi.org/10.1016/j.xnsj.2021.100086. (PMID: 10.1016/j.xnsj.2021.100086351416518820071)
Zhao Y, Xi C, Xu W, Yan J (2021) Role of tranexamic acid in blood loss control and blood transfusion management of patients undergoing multilevel spine surgery: A meta-analysis. Medicine (United States) 100(7):E24678. https://doi.org/10.1097/MD.0000000000024678. (PMID: 10.1097/MD.0000000000024678)
Zhong J, Cao K, Wang B, Zhou X, Lin N, Lu H (2019) The perioperative efficacy and safety of tranexamic acid in adolescent idiopathic scoliosis. World Neurosurg 129:e726–e732. https://doi.org/10.1016/J.WNEU.2019.05.261. (PMID: 10.1016/J.WNEU.2019.05.26131176837)
Dong Y, Liang J, Tong B, Shen J, Zhao H, Li Q (2021) Combined topical and intravenous administration of tranexamic acid further reduces postoperative blood loss in adolescent idiopathic scoliosis patients undergoing spinal fusion surgery: a randomized controlled trial. BMC Musculoskelet Disord 22(1):1–7. https://doi.org/10.1186/S12891-021-04562-5/TABLES/3. (PMID: 10.1186/S12891-021-04562-5/TABLES/3)
Wang L, Liu J, Song X, Luo M, Chen Y (2021) Hidden blood loss in adolescent idiopathic scoliosis patients undergoing posterior spinal fusion surgery: a retrospective study of 765 cases at a single centre. BMC Musculoskelet Disord 22(1):1–7. https://doi.org/10.1186/S12891-021-04681-Z/TABLES/5. (PMID: 10.1186/S12891-021-04681-Z/TABLES/5)
Yuan QM, Zhao ZH, Xu BS (2017) Efficacy and safety of tranexamic acid in reducing blood loss in scoliosis surgery: a systematic review and meta-analysis. Eur Spine J 26(1):131–139. https://doi.org/10.1007/S00586-016-4899-0/METRICS. (PMID: 10.1007/S00586-016-4899-0/METRICS27900553)
Kane Z, Picetti R, Wilby A et al (2021) Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, subcutaneous and oral administration in healthy volunteers. Eur J Pharm Sci 164:105893. https://doi.org/10.1016/J.EJPS.2021.105893. (PMID: 10.1016/J.EJPS.2021.105893340873568299544)
Kratzer S, Irl H, Mattusch C et al (2014) Tranexamic acid impairs γ-aminobutyric acid receptor type a–mediated synaptic transmission in the murine amygdalaa potential mechanism for drug-induced seizures? Anesthesiology 120(3):639–649. https://doi.org/10.1097/ALN.0000000000000103. (PMID: 10.1097/ALN.000000000000010324335749)
Ivasyk I, Chatterjee A, Jordan C et al (2022) Evaluation of the safety of tranexamic acid use in pediatric patients undergoing spinal fusion surgery: a retrospective comparative cohort study. BMC Musculoskelet Disord 23(1):1–6. https://doi.org/10.1186/S12891-022-05604-2/TABLES/2. (PMID: 10.1186/S12891-022-05604-2/TABLES/2)
Peters A, Verma K, Slobodyanyuk K et al (2015) Antifibrinolytics reduce blood loss in adult spinal deformity surgery: A prospective, randomized controlled trial. Spine (Phila Pa 1976) 40(8):E443–E449. https://doi.org/10.1097/BRS.0000000000000799. (PMID: 10.1097/BRS.000000000000079925868100)
Choi HY, Hyun SJ, Kim KJ, Jahng TA, Kim HJ (2016) Effectiveness and safety of tranexamic acid in spinal deformity surgery. J Korean Neurosurg Soc 60(1):75–81. https://doi.org/10.3340/JKNS.2016.0505.004. (PMID: 10.3340/JKNS.2016.0505.004280614955223760)
فهرسة مساهمة: Keywords: Blood loss; Pediatric deformity; Tranexamic acid
المشرفين على المادة: 6T84R30KC1 (Tranexamic Acid)
0 (Antifibrinolytic Agents)
تواريخ الأحداث: Date Created: 20240809 Date Completed: 20240809 Latest Revision: 20240809
رمز التحديث: 20240812
DOI: 10.1007/s10143-024-02599-3
PMID: 39122900
قاعدة البيانات: MEDLINE
الوصف
تدمد:1437-2320
DOI:10.1007/s10143-024-02599-3