دورية أكاديمية
Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion.
العنوان: | Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion. |
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المؤلفون: | Carvalho A; Universidade Estadual Do Piauí, Teresina, Brazil., da Luz Silva I; Universidade Estadual Do Piauí, Teresina, Brazil., da Cruz Neto PR; Universidade Estadual Do Piauí, Teresina, Brazil., Pokorny G; Instituto de Patologia da Coluna, São Paulo, Brazil. ghpokorny@gmail.com., Amaral R; Instituto de Patologia da Coluna, São Paulo, Brazil., Pratali R; Hospital Do Servidor Público Estadual, São Paulo, Brazil., Acácio R; Instituto de Ortopedia E Traumatologia de Joinville, Joinville, Brazil., Romeiro C; Instituto de Coluna E Ortopedia de Recife (InCore), Recife, Brazil., Magno MV; Universidade da Região de Joinville (UNIVILLE), Joinville, Brazil., Daher M; Centro de Reabilitação E Readaptação Dr. Henrique Santillo (CRER), Goiânia, Brazil., Herrero CFPS; Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil. |
مؤلفون مشاركون: | Brazilian Spine Study Group |
المصدر: | Neurosurgical review [Neurosurg Rev] 2024 Aug 10; Vol. 47 (1), pp. 416. Date of Electronic Publication: 2024 Aug 10. |
نوع المنشور: | Journal Article; Randomized Controlled Trial |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Berlin Heidelberg Country of Publication: Germany NLM ID: 7908181 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-2320 (Electronic) Linking ISSN: 03445607 NLM ISO Abbreviation: Neurosurg Rev Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Berlin : Springer Berlin Heidelberg Original Publication: Berlin : Walter De Gruyter |
مواضيع طبية MeSH: | Tranexamic Acid*/therapeutic use , Scoliosis*/surgery , Spinal Fusion*/methods , Spinal Fusion*/adverse effects , Antifibrinolytic Agents*/therapeutic use , Blood Loss, Surgical*/prevention & control, Humans ; Female ; Male ; Adolescent ; Prospective Studies ; Adult ; Blood Transfusion/statistics & numerical data ; Treatment Outcome ; Postoperative Period ; Length of Stay ; Young Adult ; Postoperative Hemorrhage/epidemiology |
مستخلص: | Scoliosis is the most prevalent type of spinal deformity, with a 2-3% prevalence in the general population. Moreover, surgery for scoliotic deformity may result in severe blood loss and, consequently, the need for blood transfusions, thereby increasing surgical morbidity and the rate of complications. Several antifibrinolytic drugs, such as tranexamic acid, have been regarded as safe and effective options for reducing blood loss. Therefore, the present study aimed to analyse the effectiveness of this drug for controlling bleeding when used intraoperatively and in the first 48 h after surgery. A prospective randomized study of a cohort of patients included in a mass event for scoliosis treatment using PSF was performed. Twenty-eight patients were analysed and divided into two groups: 14 patients were selected for intraoperative and postoperative use of tranexamic acid (TXA), and the other 14 were selected only during the intraoperative period. The drainage bleeding rate, length of hospital stay, number of transfused blood units, and rate of adverse clinical effects were compared. All the patients involved had similar numbers of fusion levels addressed and similar scoliosis profiles. The postoperative bleeding rate through the drain did not significantly differ between the two groups (p > 0.05). There was no significant difference in the number of transfused blood units between the groups (p = 0.473); however, in absolute numbers, patients in the control group received more transfusions. The length of hospital stay was fairly similar between the groups, with no statistically significant difference. Furthermore, the groups had similar adverse effects (p = 0.440), with the exception of nausea and vomiting, which were twice as common in the TXA group postoperatively than in the control group. No significant differences were found in the use of TXA during the first 48 postoperative hours or in postoperative outcomes. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Blood loss; Pediatric deformity; Tranexamic acid |
المشرفين على المادة: | 6T84R30KC1 (Tranexamic Acid) 0 (Antifibrinolytic Agents) |
تواريخ الأحداث: | Date Created: 20240809 Date Completed: 20240809 Latest Revision: 20240809 |
رمز التحديث: | 20240812 |
DOI: | 10.1007/s10143-024-02599-3 |
PMID: | 39122900 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1437-2320 |
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DOI: | 10.1007/s10143-024-02599-3 |