دورية أكاديمية
أعرض في EDS

Influence of Varied Dietary Cholesterol Levels on Lipid Metabolism in Hamsters.

التفاصيل البيبلوغرافية
العنوان: Influence of Varied Dietary Cholesterol Levels on Lipid Metabolism in Hamsters.
المؤلفون: Huang CH; Department of Food Science, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan., Hsu HS; Department of Food Science, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan., Chiang MT; Department of Food Science, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan.
المصدر: Nutrients [Nutrients] 2024 Jul 30; Vol. 16 (15). Date of Electronic Publication: 2024 Jul 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Mesocricetus* , Lipid Metabolism* , Cholesterol, Dietary*/administration & dosage , Liver*/metabolism, Animals ; Male ; Cricetinae ; Feces/chemistry ; Oxidative Stress ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/blood ; Cholesterol, LDL/blood ; Lipid Peroxidation ; Cholesterol/blood ; Cholesterol/metabolism ; Bile Acids and Salts/metabolism ; Leptin/blood ; Leptin/metabolism ; Cholesterol Ester Transfer Proteins/metabolism
مستخلص: Syrian hamsters are valuable models for studying lipid metabolism due to their sensitivity to dietary cholesterol, yet the precise impact of varying cholesterol levels has not been comprehensively assessed. This study examined the impact of varying dietary cholesterol levels on lipid metabolism in Syrian hamsters. Diets ranging from 0% to 1% cholesterol were administered to assess lipid profiles and oxidative stress markers. Key findings indicate specific cholesterol thresholds for inducing distinct lipid profiles: below 0.13% for normal lipids, 0.97% for elevated LDL-C, 0.43% for increased VLDL-C, and above 0.85% for heightened hepatic lipid accumulation. A cholesterol supplementation of 0.43% induced hypercholesterolemia without adverse liver effects or abnormal lipoprotein expression. Furthermore, cholesterol supplementation significantly increased liver weight, plasma total cholesterol, LDL-C, and VLDL-C levels while reducing the HDL-C/LDL-C ratio. Fecal cholesterol excretion increased, with stable bile acid levels. High cholesterol diets correlated with elevated plasma ALT activities, reduced hepatic lipid peroxidation, and altered leptin and CETP levels. These findings underscore Syrian hamsters as robust models for hyperlipidemia research, offering insights into experimental methodologies. The identified cholesterol thresholds facilitate precise lipid profile manipulation, enhancing the hamster's utility in lipid metabolism studies and potentially informing clinical approaches to managing lipid disorders.
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معلومات مُعتمدة: 92200001 NTOU
فهرسة مساهمة: Keywords: Syrian hamsters; cholesterol excretion; hypercholesterolemia; hyperlipidemia; lipid accumulation; lipid metabolism; lipid peroxidation; varying dietary cholesterol levels
المشرفين على المادة: 0 (Cholesterol, Dietary)
0 (Cholesterol, LDL)
97C5T2UQ7J (Cholesterol)
0 (Bile Acids and Salts)
0 (Leptin)
0 (Cholesterol Ester Transfer Proteins)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11314022
DOI: 10.3390/nu16152472
PMID: 39125351
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16152472