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Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53.
المؤلفون: Ammanath AV; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany., Matsuo M; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany., Wang H; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany., Kraus F; Organic Chemistry I, Faculty of Chemistry and Food Chemistry, Technical University Dresden, 01062 Dresden, Germany., Bleisch A; Organic Chemistry I, Faculty of Chemistry and Food Chemistry, Technical University Dresden, 01062 Dresden, Germany., Peslalz P; Organic Chemistry I, Faculty of Chemistry and Food Chemistry, Technical University Dresden, 01062 Dresden, Germany., Mohammad M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden., Deshmukh M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden., Grießhammer A; Interfakultäres Institut für Mikrobiologie und Infektionsmedizin (IMIT), University of Tübingen, 72076 Tübingen, Germany.; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany., Purkayastha M; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany., Vorbach A; Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany., Macek B; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany.; Quantitative Proteomics, Proteome Center Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, 72076 Tübingen, Germany., Brötz-Oesterhelt H; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany.; Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany., Maier L; Interfakultäres Institut für Mikrobiologie und Infektionsmedizin (IMIT), University of Tübingen, 72076 Tübingen, Germany.; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany., Kretschmer D; Interfakultäres Institut für Mikrobiologie und Infektionsmedizin (IMIT), University of Tübingen, 72076 Tübingen, Germany.; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany., Peschel A; Interfakultäres Institut für Mikrobiologie und Infektionsmedizin (IMIT), University of Tübingen, 72076 Tübingen, Germany.; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany., Jin T; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden., Plietker B; Organic Chemistry I, Faculty of Chemistry and Food Chemistry, Technical University Dresden, 01062 Dresden, Germany., Götz F; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, 72076 Tübingen, Germany.; Excellence Cluster 2124 'Controlling Microbes to Fight Infections' (CMFI), University of Tübingen, 72076 Tübingen, Germany.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 23; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Ketones*/chemistry , Ketones*/pharmacology , Methicillin-Resistant Staphylococcus aureus*/drug effects , Spiro Compounds*/chemistry , Spiro Compounds*/pharmacology, Animals ; Humans ; Mice ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Enterococcus faecium/drug effects ; Larva/drug effects ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Moths/drug effects ; Staphylococcal Infections/drug therapy
مستخلص: Polycyclic polyprenylated acylphloroglucinols (PPAPs) comprise a large group of compounds of mostly plant origin. The best-known compound is hyperforin from St. John's wort with its antidepressant, antitumor and antimicrobial properties. The chemical synthesis of PPAP variants allows the generation of compounds with improved activity and compatibility. Here, we studied the antimicrobial activity of two synthetic PPAP-derivatives, the water-insoluble PPAP23 and the water-soluble sodium salt PPAP53. In vitro, both compounds exhibited good activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium . Both compounds had no adverse effects on Galleria mellonella wax moth larvae. However, they were unable to protect the larvae from infection with S. aureus because components of the larval coelom neutralized the antimicrobial activity; a similar effect was also seen with serum albumin. In silico docking studies with PPAP53 revealed that it binds to the F1 pocket of human serum albumin with a binding energy of -7.5 kcal/mol. In an infection model of septic arthritis, PPAP23 decreased the formation of abscesses and S. aureus load in kidneys; in a mouse skin abscess model, topical treatment with PPAP53 reduced S. aureus counts. Both PPAPs were active against anaerobic Gram-positive gut bacteria such as neurotransmitter-producing Clostridium , Enterococcus or Ruminococcus species. Based on these results, we foresee possible applications in the decolonization of pathogens.
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معلومات مُعتمدة: GO 371/18-1 Deutsche Forschungsgemeinschaft; AntibioPPAP Ministry for Science, Research and the Arts of Baden-Wuerttemberg (MWK)
فهرسة مساهمة: Keywords: PPAP; albumin; antimicrobial activity; gastrointestinal anaerobes; larvae; mouse septic arthroses
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Ketones)
0 (PPAP53)
0 (Spiro Compounds)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11312133
DOI: 10.3390/ijms25158023
PMID: 39125595
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25158023