دورية أكاديمية
أعرض في EDS

Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis.

التفاصيل البيبلوغرافية
العنوان: Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis.
المؤلفون: Rodríguez-González D; Division of Central Laboratory, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain., García-González M; Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain., Gómez-Bernal F; Division of Central Laboratory, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain., Quevedo-Abeledo JC; Division of Rheumatology, Hospital Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain., González-Rivero AF; Division of Central Laboratory, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain., Fernández-Cladera Y; Division of Central Laboratory, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain., González-López E; Division of Immunology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Valdecilla (IDIVAL), 39011 Santander, Spain., Ocejo-Vinyals JG; Division of Immunology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Valdecilla (IDIVAL), 39011 Santander, Spain., Jiménez-Sosa A; Research Unit, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain., González-Toledo B; Fundación Jimenez Díaz School of Nursing, Autonomous University of Madrid, 28040 Madrid, Spain.; Health Research Institute, Fundación Jiménez Díaz, 28040 Madrid, Spain., González-Gay MÁ; Division of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.; Deparment of Internal Medicine, University of Cantabria, 39005 Santander, Spain., Ferraz-Amaro I; Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain.; Department of Internal Medicine, University of La Laguna (ULL), 38200 Santa Cruz de Tenerife, Spain.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 31; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Arthritis, Rheumatoid*/blood , Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/metabolism , Rheumatoid Factor*/blood, Humans ; Male ; Female ; Middle Aged ; Aged ; Adult ; Complement System Proteins/metabolism ; Complement System Proteins/immunology ; Anti-Citrullinated Protein Antibodies/blood ; Complement Pathway, Alternative ; Complement Activation ; C-Reactive Protein/metabolism ; C-Reactive Protein/analysis ; Complement Pathway, Classical
مستخلص: The complement (C) system is implicated in the etiopathogenesis of rheumatoid arthritis (RA). However, there is a lack of studies characterizing all three C pathways in RA patients. This study aimed to evaluate the association between an in-depth examination of the C system and RA patient characteristics, focusing on disease activity and the presence of rheumatoid factor and anti-citrullinated protein autoantibodies (ACPA). In a cohort of 430 RA patients, functional assays of the three C pathways (classical, alternative, and lectin) and serum levels of their components were assessed. Components included C1q (classical); factor D and properdin (alternative); lectin (lectin); C1-inhibitor; C2, C4, and C4b (classical and lectin); C3, C3a, and C4b (common); and C5, C5a, and C9 (terminal). A multivariable linear regression analysis showed significant positive correlations between C-reactive protein and C system proteins and functional assays, especially in the terminal and common pathways. Disease activity, measured by scores with or without acute phase reactants, positively correlated with the classical pathway functional test and terminal pathway products. Conversely, rheumatoid factor or ACPA presence was associated with lower classical pathway values and decreased C3a and C4b levels, suggesting complement depletion. In conclusion, RA disease activity increases C molecules and functional complement assays, while rheumatoid factor or ACPA positivity is linked to C consumption. Our study offers a detailed analysis of the complement system's role in RA, potentially guiding the development of more targeted and effective treatment strategies.
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معلومات مُعتمدة: PI20/00084 Instituto de Salud Carlos III
فهرسة مساهمة: Keywords: anti-citrullinated protein autoantibodies; complement activity assays; complement pathways; complement system; disease activity; inflammation; rheumatoid arthritis; rheumatoid factor
المشرفين على المادة: 9009-79-4 (Rheumatoid Factor)
9007-36-7 (Complement System Proteins)
0 (Anti-Citrullinated Protein Antibodies)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240812
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11312865
DOI: 10.3390/ijms25158360
PMID: 39125933
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25158360