دورية أكاديمية
Development and implementation of assays to monitor human adenovirus F40/41 in wastewater: Trends preceding, during, and following the non-A-to-E hepatitis outbreak in Stockholm.
| العنوان: | Development and implementation of assays to monitor human adenovirus F40/41 in wastewater: Trends preceding, during, and following the non-A-to-E hepatitis outbreak in Stockholm. |
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| المؤلفون: | Perez-Zabaleta M; Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, SE-10691 Stockholm, Sweden. Electronic address: mnpz@kth.se., Williams C; Department of Protein Science, KTH Royal Institute of Technology, Science for Life Laboratory, SE-171 65 Solna, Sweden., Cetecioglu Z; Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, SE-10691 Stockholm, Sweden. |
| المصدر: | Environment international [Environ Int] 2024 Aug; Vol. 190, pp. 108937. Date of Electronic Publication: 2024 Aug 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Oxford; Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Adenoviruses, Human*/genetics , Adenoviruses, Human*/isolation & purification , Wastewater*/virology , Disease Outbreaks*, Sweden/epidemiology ; Humans ; Hepatitis/epidemiology ; Hepatitis/virology ; Adenovirus Infections, Human/epidemiology ; Adenovirus Infections, Human/virology ; SARS-CoV-2/genetics |
| مستخلص: | Human adenovirus (HAdV) type F41 has been identified as a possible cause of the non-A-to-E hepatitis outbreak. This study uses wastewater monitoring to track HAdV F40 and F41, supporting clinical investigations and providing insights into the pathogen's role in the outbreak. Given the limited clinical monitoring in Sweden of HAdV-F40/41, this approach also helps estimate the true infection burden of this pathogen during the outbreak. This study developed three qPCR assays for the hexon, penton, and fiber genes of HAdV F40 and F41. The hexon assay was F41-specific, while the fiber assay detected multiple HAdV-F strains. Comprehensive monitoring of HAdV-F40/41 levels in Stockholm's wastewater was conducted over 1.5 years, capturing the period before, during, and after the outbreak. A significant infection wave was observed in spring 2022, with strains beyond lineage 2 contributing to the outbreak. Moreover, simultaneous SARS-CoV-2 surveillance revealed that HAdV-F infections peaked at different times from COVID-19, but the HAdV-F wave aligned with the relaxation of pandemic restrictions. These findings offer valuable insights for future HAdV-F investigations and confirm its role in the non-A-to-E hepatitis outbreak. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Human adenovirus F40; Human adenovirus F41; Wastewater-based epidemiology; non-A-to-E hepatitis |
| المشرفين على المادة: | 0 (Wastewater) |
| تواريخ الأحداث: | Date Created: 20240810 Date Completed: 20240827 Latest Revision: 20240827 |
| رمز التحديث: | 20240827 |
| DOI: | 10.1016/j.envint.2024.108937 |
| PMID: | 39126729 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6750 |
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| DOI: | 10.1016/j.envint.2024.108937 |