دورية أكاديمية
Auditory entrainment coordinates cortical-BNST-NAc triple time locking to alleviate the depressive disorder.
| العنوان: | Auditory entrainment coordinates cortical-BNST-NAc triple time locking to alleviate the depressive disorder. |
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| المؤلفون: | Lv X; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang Y; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang Y; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Neural and Intelligence Engineering Centre, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China., Ma S; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu J; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Ye K; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wu Y; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Voon V; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Neural and Intelligence Engineering Centre, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Department of Psychiatry, Addenbrookes Hospital, University of Cambridge, CB2 0QQ Cambridge, UK. Electronic address: ku.ca.mac@742vv.com., Sun B; Center of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: bomin_sun@163.com. |
| المصدر: | Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114474. Date of Electronic Publication: 2024 Aug 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Auditory Cortex*/physiology , Auditory Cortex*/physiopathology , Nucleus Accumbens*/physiology, Humans ; Male ; Female ; Adult ; Septal Nuclei/physiology ; Septal Nuclei/physiopathology ; Acoustic Stimulation ; Electroencephalography ; Depressive Disorder, Major/therapy ; Depressive Disorder, Major/physiopathology ; Middle Aged |
| مستخلص: | Listening to music is a promising and accessible intervention for alleviating symptoms of major depressive disorder. However, the neural mechanisms underlying its antidepressant effects remain unclear. In this study on patients with depression, we used auditory entrainment to evaluate intracranial recordings in the bed nucleus of the stria terminalis (BNST) and nucleus accumbens (NAc), along with temporal scalp electroencephalogram (EEG). We highlight music-induced synchronization across this circuit. The synchronization initiates with temporal theta oscillations, subsequently inducing local gamma oscillations in the BNST-NAc circuit. Critically, the incorporated external entrainment induced a modulatory effect from the auditory cortex to the BNST-NAc circuit, activating the antidepressant response and highlighting the causal role of physiological entrainment in enhancing the antidepressant response. Our study explores the pivotal role of the auditory cortex and proposes a neural oscillation triple time-locking model, emphasizing the capacity of the auditory cortex to access the BNST-NAc circuit. Competing Interests: Declaration of interests This study was funded by the National Natural Science Foundation of China (82271515), the SJTU Trans-med Awards Research (2019015), the Scientific and Technological Innovation Action Plan of Shanghai (KY20211478), and the Shanghai Municipal Science and Technology Major Project (2021SHZDZX). (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CP: Neuroscience; EEG; NAc; gamma oscillation; machine learning; major depressive disorder; music treatment; neuromodulation |
| تواريخ الأحداث: | Date Created: 20240810 Date Completed: 20240830 Latest Revision: 20240831 |
| رمز التحديث: | 20240831 |
| DOI: | 10.1016/j.celrep.2024.114474 |
| PMID: | 39127041 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2024.114474 |