دورية أكاديمية
أعرض في EDS

The evaluation of nightshade elimination diet (NED) on inflammatory and rheumatologic markers of rheumatoid arthritis patients: study protocol for a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: The evaluation of nightshade elimination diet (NED) on inflammatory and rheumatologic markers of rheumatoid arthritis patients: study protocol for a randomized controlled trial.
المؤلفون: Golmohammadi A; Department of Sport Sciences, College of Education and Psychology, Shiraz University, Shiraz, Iran., Hosseinikia M; Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical University of Medical Sciences, Yasuj, Iran., Sadeghi MK; Department of Internal Medicine, School of Medicine, Imam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran., Golampur D; Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Hosseinzadeh Z; Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran., Panahande SB; Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran. panahande.b@gmail.com.; Imamsajad Hospital Clinical Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. panahande.b@gmail.com.
المصدر: Trials [Trials] 2024 Aug 10; Vol. 25 (1), pp. 531. Date of Electronic Publication: 2024 Aug 10.
نوع المنشور: Clinical Trial Protocol; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Arthritis, Rheumatoid*/blood , Arthritis, Rheumatoid*/diet therapy , Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/diagnosis , Biomarkers*/blood , Elimination Diets* , Randomized Controlled Trials as Topic*, Adult ; Female ; Humans ; Male ; Middle Aged ; Inflammation Mediators/blood ; Single-Blind Method ; Time Factors ; Treatment Outcome
مستخلص: Background: Rheumatoid arthritis (RA) is a chronic disease with a global prevalence rate of 1%. Patients with RA often associate specific foods like tomatoes and eggplants with adverse symptoms. These plants contain solanine, which could potentially contribute to bone and joint damage. Despite patient reports, there is a lack of randomized controlled trials (RCTs) investigating the effects of nightshades on patients with RA. This study aims to assess the effect of nightshade elimination diet (NED) on inflammatory and rheumatologic marker levels in rheumatoid arthritis patients for the first time.
Methods: A single-blinded controlled trial will be conducted to evaluate the effect of an NED on 40 participants over 8 weeks (2 months). Participants will be equally divided into intervention and placebo groups. Both groups will receive general anti-inflammatory dietary recommendations, with the intervention group undergoing an NED during the study. Clinical symptoms will be assessed using questionnaires, and blood samples will be collected to measure relevant indicators.
Discussion: This RCT signifies a groundbreaking exploration into NED effects on RA markers, potentially initiating crucial discussions in the field. Its outcomes could serve as a cornerstone for larger and more robust trials, offering pivotal insights to nutritionists and physicians for the nuanced management of patients with RA.
Trial Registration: Iranian Registry of Clinical Trials IRCT20230220057465N1 ( https://irct.behdasht.gov.ir/trial/68959 ). Registered on 8 April 2023.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Nightshade elimination diet; Randomized controlled trial (RCT); Rheumatoid arthritis; Study protocol
المشرفين على المادة: 0 (Biomarkers)
0 (Inflammation Mediators)
تواريخ الأحداث: Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240826
رمز التحديث: 20240827
مُعرف محوري في PubMed: PMC11316282
DOI: 10.1186/s13063-024-08372-7
PMID: 39127701
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-6215
DOI:10.1186/s13063-024-08372-7