دورية أكاديمية
أعرض في EDS

Association between ankle-brachial blood pressure index and erectile dysfunction in US adults: a large population-based cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Association between ankle-brachial blood pressure index and erectile dysfunction in US adults: a large population-based cross-sectional study.
المؤلفون: Wu X; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Zhang Y; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Zheng X; Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jul 26; Vol. 15, pp. 1436043. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Erectile Dysfunction*/epidemiology , Erectile Dysfunction*/physiopathology , Ankle Brachial Index* , Blood Pressure*/physiology , Nutrition Surveys*, Humans ; Male ; Cross-Sectional Studies ; Middle Aged ; Adult ; United States/epidemiology ; Aged ; Risk Factors ; Prevalence
مستخلص: Background: Erectile dysfunction (ED) is a very common condition among adult men and its prevalence increases with age. The ankle-brachial blood pressure index (ABPI) is a noninvasive tool used to assess peripheral vascular disease (PAD) and vascular stiffness. However, the association between ABPI and ED is unclear. We aimed to explore the association between ABPI and ED in the US population.
Methods: Our study used data from two separate National Health and Nutrition Examination Survey (NHANES) datasets (2001-2002 and 2003-2004). Survey-weighted logistic regression models were used to explore the association between ABPI as a continuous variable and quartiles with ED. We further assessed the association between ABPI and ED using restricted cubic regression while selecting ABPI thresholds using two-piecewise Cox regression models. In addition, we performed subgroup analyses stratified by BMI, race, marital status, diabetes, and hypertension.
Main Outcome Measure: ABPI was calculated by dividing the mean systolic blood pressure at the ankle by the mean systolic blood pressure at the arm.
Results: Finally, 2089 participants were enrolled in this study, including 750 (35.90%) ED patients and 1339 (64.10%) participants without ED. After adjusting for all confounding covariates, logistic regression analyses showed a significant association between ABPI and ED (OR=0.19; 95% CI, 0.06-0.56, P=0.01); with ABPI as a categorical variable, compared with the lowest quartile, the OR and 95% CI for the second quartile were 0.58 (0.34-0.97; P = 0.04).Besides, splines indicated that there was an L-shaped relationship between ABPI levels and the risk of ED. Piecewise Cox regression demonstrated the inflection point at 1.14, below which the OR for ED was 0.06 (0.02-0.20; P < 0.001), and above which the OR was 2.79 (0.17-4.53; P = 0.469).
Conclusion: In our study, lower ABPI was independently associated with ED risk. In addition, the lowest ABPI level associated with ED risk was 1.14, below this level, lower ABPI was associated with higher ED risk.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Wu, Zhang and Zheng.)
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فهرسة مساهمة: Keywords: ankle-brachial blood pressure index; erectile dysfunction; logistic regression; national health and nutrition examination survey; peripheral vascular disease
تواريخ الأحداث: Date Created: 20240812 Date Completed: 20240812 Latest Revision: 20240813
رمز التحديث: 20240813
مُعرف محوري في PubMed: PMC11310141
DOI: 10.3389/fendo.2024.1436043
PMID: 39129923
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2024.1436043