دورية أكاديمية
CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function.
| العنوان: | CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function. |
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| المؤلفون: | Li Y; Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN, United States., Wu J; Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN, United States.; Department of Medicine, University of Minnesota, Minneapolis, MN, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Jul 26; Vol. 15, pp. 1418539. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Immunoglobulin G*/immunology , GPI-Linked Proteins*/genetics , GPI-Linked Proteins*/metabolism , GPI-Linked Proteins*/immunology, Humans ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Receptors, Cell Surface/immunology ; Antibody-Dependent Cell Cytotoxicity ; Receptors, IgG/genetics ; Receptors, IgG/metabolism ; Isoantigens/immunology ; Isoantigens/genetics ; Genetic Variation ; Receptors, Fc/metabolism ; Receptors, Fc/genetics ; Protein Binding |
| مستخلص: | CD177 plays an important role in the proliferation and differentiation of myeloid lineage cells including neutrophils, myelocytes, promyelocytes, megakaryocytes, and early erythroblasts in bone marrow. CD177 deficiency is a common phenotype in humans. Our previous studies revealed genetic mechanisms of human CD177 deficiency and expression variations. Up to now, immune functions of CD177 remain undefined. In the current study, we revealed human IgG as a ligand for CD177 by using flow cytometry, bead-rosette formation, and surface plasmon resonance (SPR) assays. In addition, we show that CD177 variants affect the binding capacity of CD177 for human IgG. Furthermore, we show that the CD177 genetic variants significantly affect antibody-dependent cell-mediated cytotoxicity (ADCC) function. The demonstration of CD177 as a functional IgG Fc-receptor may provide new insights into CD177 immune function and genetic mechanism underlying CD177 as biomarkers for human diseases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Li and Wu.) |
| التعليقات: | Update of: bioRxiv. 2024 Jan 08:2024.01.07.574546. doi: 10.1101/2024.01.07.574546. (PMID: 38260289) |
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| فهرسة مساهمة: | Keywords: ADCC - antibody dependent cellular cytotoxicity; CD177; IgG Fc receptor; genetic variants; immune function |
| المشرفين على المادة: | 0 (Immunoglobulin G) 0 (CD177 protein, human) 0 (GPI-Linked Proteins) 0 (Receptors, Cell Surface) 0 (Receptors, IgG) 0 (Isoantigens) 0 (Receptors, Fc) |
| تواريخ الأحداث: | Date Created: 20240812 Date Completed: 20240812 Latest Revision: 20240815 |
| رمز التحديث: | 20240815 |
| مُعرف محوري في PubMed: | PMC11316256 |
| DOI: | 10.3389/fimmu.2024.1418539 |
| PMID: | 39131159 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2024.1418539 |