دورية أكاديمية
Management of advanced high grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): comprehensive review of the current literature.
| العنوان: | Management of advanced high grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): comprehensive review of the current literature. |
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| المؤلفون: | Mohamed A; Division of Hematology and Medical Oncology, UH Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Trybula M; Division of Hematology and Medical Oncology, UH Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Asa SL; Department of Medicine, UH Seidman Cancer Center Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Halfdanarson TR; Division of Medical Oncology, Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota, USA., Sonbol MB; Division of Hematology and Medical Oncology, Mayo Clinic Cancer Center, Phoenix, Arizona, USA. |
| المصدر: | Endocrine-related cancer [Endocr Relat Cancer] 2024 Sep 21; Vol. 31 (10). Date of Electronic Publication: 2024 Sep 21 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 9436481 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1479-6821 (Electronic) Linking ISSN: 13510088 NLM ISO Abbreviation: Endocr Relat Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Woodlands, Almondsbury, Bristol, UK : Published for the Society of Endocrinology by the Journal of Endocrinology Ltd., 1994- |
| مواضيع طبية MeSH: | Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/therapy , Pancreatic Neoplasms*/classification , Pancreatic Neoplasms*/genetics , Neuroendocrine Tumors*/therapy , Neuroendocrine Tumors*/pathology , Neuroendocrine Tumors*/classification , Neuroendocrine Tumors*/genetics , Intestinal Neoplasms*/pathology , Intestinal Neoplasms*/therapy , Intestinal Neoplasms*/classification, Humans ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Stomach Neoplasms/classification ; Stomach Neoplasms/genetics ; Neoplasm Grading |
| مستخلص: | The classification and management of neuroendocrine neoplasms (NENs) arising in the tubular gastrointestinal (GI) tract and pancreas have significantly evolved over the last decades. In the latest WHO classification published in 2022, NENs are separated regardless of their primary origin into two main groups: well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). The substantial changes in the grading system changed the definition of grade 3 to include high-grade well-differentiated NETs (G3-NETs), and poorly differentiated NECs (-NECs). Although these two subgroups are considered high grades with Ki-67 >20%, they have different genomic profiles, prognosis, and clinical behavior, which critically influence their treatment strategies. The available clinical trial data to guide therapy of these high-grade subgroups are extremely limited, which impacts their management. In this review, we will summarize the current advances in the multidisciplinary approach for the management of high-grade gastroenteropancreatic NENs (GEP-NENs) including G3-NETs and NECs. |
| فهرسة مساهمة: | Keywords: high grade; neoplasms; neuroendocrine |
| SCR Disease Name: | Gastro-enteropancreatic neuroendocrine tumor |
| تواريخ الأحداث: | Date Created: 20240812 Date Completed: 20240924 Latest Revision: 20240924 |
| رمز التحديث: | 20240925 |
| DOI: | 10.1530/ERC-24-0025 |
| PMID: | 39133180 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1479-6821 |
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| DOI: | 10.1530/ERC-24-0025 |