دورية أكاديمية
أعرض في EDS

A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment.

التفاصيل البيبلوغرافية
العنوان: A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment.
المؤلفون: Hines MR; The University of Iowa, Iowa City, IA, USA., Gomez-Contreras PC; The University of Iowa, Iowa City, IA, USA., Liman S; The University of Iowa, Iowa City, IA, USA., Wilson AM; The University of Iowa, Iowa City, IA, USA., Lu KJ; The University of Iowa, Iowa City, IA, USA., O'Neill JA; The University of Iowa, Iowa City, IA, USA., Fisher JS; The University of Iowa, Iowa City, IA, USA., Fredericks DC; The University of Iowa, Iowa City, IA, USA., Wagner BA; The University of Iowa, Iowa City, IA, USA., Buettner GR; The University of Iowa, Iowa City, IA, USA., Van Remmen H; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Coleman MC; The University of Iowa, Iowa City, IA, USA. Electronic address: mitchell-coleman@uiowa.edu.
المصدر: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103306. Date of Electronic Publication: 2024 Aug 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam]: Elsevier, B.V., [2013]-
مواضيع طبية MeSH: Chondrocytes*/metabolism , Chondrocytes*/drug effects , Lipid Peroxidation* , Mitochondria*/metabolism , Mitochondria*/drug effects , Oxidation-Reduction* , Oxidative Stress*/drug effects, Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Cartilage, Articular/metabolism ; Mice ; Cells, Cultured
مستخلص: In orthopedic research, many studies have applied vitamin E as a protective antioxidant or used tert-butyl hydroperoxide to induce oxidative injury to chondrocytes. These studies often support the hypothesis that joint pathology causes oxidative stress and increased lipid peroxidation that might be prevented with lipid antioxidants to improve cell survival or function and joint health; however, lipid antioxidant supplementation was ineffective against osteoarthritis in clinical trials and animal data have been equivocal. Moreover, increased circulating vitamin E is associated with increased rates of osteoarthritis. This disconnect between benchtop and clinical results led us to hypothesize that oxidative stress-driven paradigms of chondrocyte redox function do not capture the metabolic and physiologic effects of lipid antioxidants and prooxidants on articular chondrocytes. We used ex vivo and in vivo cartilage models to investigate the effect of lipid antioxidants on healthy, primary, articular chondrocytes and applied immuno-spin trapping techniques to provide a broad indicator of high levels of oxidative stress independent of specific reactive oxygen species. Key findings demonstrate lipid antioxidants were pro-mitochondrial while lipid prooxidants decreased mitochondrial measures. In the absence of injury, radical formation was increased by lipid antioxidants; however, in the presence of injury, radical formation was decreased. In unstressed conditions, this relationship between chondrocyte mitochondria and redox regulation was reproduced in vivo with overexpression of glutathione peroxidase 4. In mice aged 18 months or more, overexpression of glutathione peroxidase 4 significantly decreased the presence of pro-mitochondrial peroxisome proliferation activated receptor gamma and deranged the relationship between mitochondria and the redox environment. This complex interaction suggests strategies targeting articular cartilage may benefit from adopting more nuanced paradigms of articular chondrocyte redox metabolism.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: AR070914 National Institute of Arthritis and Musculoskeletal and Skin
فهرسة مساهمة: Keywords: Cartilage; Chondrocyte; Glutathione peroxidase 4; Immuno-spin trapping; Lipid peroxidation; Mitochondria
المشرفين على المادة: 0 (Antioxidants)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20240812 Date Completed: 20240821 Latest Revision: 20240919
رمز التحديث: 20240919
مُعرف محوري في PubMed: PMC11366903
DOI: 10.1016/j.redox.2024.103306
PMID: 39133964
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-2317
DOI:10.1016/j.redox.2024.103306