دورية أكاديمية
Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma.
| العنوان: | Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma. |
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| المؤلفون: | Körner M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Spohn M; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.; Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bockmayr M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.; bAIome - Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany. |
| المصدر: | Oncoimmunology [Oncoimmunology] 2024 Aug 09; Vol. 13 (1), pp. 2386789. Date of Electronic Publication: 2024 Aug 09 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: eCollection Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, TX : Landes Bioscience |
| مواضيع طبية MeSH: | Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Glioma*/genetics , Glioma*/immunology , Glioma*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/immunology, Humans ; Child ; Female ; Male ; Neoplasm Grading ; Gene Expression Profiling ; Transcriptome ; Child, Preschool ; Adolescent ; Stromal Cells/pathology ; Stromal Cells/metabolism ; Stromal Cells/immunology |
| مستخلص: | Immunologic treatment options are uncommon in low-grade gliomas, although such therapies might be beneficial for inoperable and aggressive cases. Knowledge of the immune and stromal cells in low-grade gliomas is highly relevant for such approaches but still needs to be improved. Published gene-expression data from 400 low-grade gliomas and 193 high-grade gliomas were gathered to quantify 10 microenvironment cell populations with a deconvolution method designed explicitly for brain tumors. First, we investigated general differences in the microenvironment of low- and high-grade gliomas. Lower-grade and high-grade tumors cluster together, respectively, and show a general similarity within and distinct differences between these groups, the main difference being a higher infiltration of fibroblasts and T cells in high-grade gliomas. Among the analyzed entities, gangliogliomas and pleomorphic xanthoastrocytomas presented the highest overall immune cell infiltration. Further analyses of the low-grade gliomas presented three distinct microenvironmental signatures of immune cell infiltration, which can be divided into T-cell/dendritic/natural killer cell-, neutrophilic/B lineage/natural killer cell-, and monocytic/vascular/stromal-cell-dominated immune clusters. These clusters correlated with tumor location, age, and histological diagnosis but not with sex or progression-free survival. A survival analysis showed that the prognosis can be predicted from gene expression, clinical data, and a combination of both with a support vector machine and revealed the negative prognostic relevance of vascular markers. Overall, our work shows that low- and high-grade gliomas can be characterized and differentiated by their immune cell infiltration. Low-grade gliomas cluster into three distinct immunologic tumor microenvironments, which may be of further interest for upcoming immunotherapeutic research. Competing Interests: No potential conflict of interest was reported by the author(s). (© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.) |
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| فهرسة مساهمة: | Keywords: Astrocytoma; deconvolution; gene expression; low-grade glioma; tumor microenvironment |
| تواريخ الأحداث: | Date Created: 20240813 Date Completed: 20240813 Latest Revision: 20240814 |
| رمز التحديث: | 20240814 |
| مُعرف محوري في PubMed: | PMC11318680 |
| DOI: | 10.1080/2162402X.2024.2386789 |
| PMID: | 39135890 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2162-402X |
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| DOI: | 10.1080/2162402X.2024.2386789 |