دورية أكاديمية
National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.
| العنوان: | National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study. |
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| المؤلفون: | Colby E; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Hayward S; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Benavente M; Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK., Robertson F; Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK., Bierzynska A; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Osborne A; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Parmesar K; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Afzal M; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Chapman T; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Ullah F; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Davies E; Kidney Research UK, Peterborough, UK., Nation M; Kidney Research UK, Peterborough, UK., Cook W; Nephrotic Syndrome Trust, Somerset, UK., Johnson T; Experimental Renal Medicine, Medical School, University of Sheffield, Sheffield, UK., Andag U; Metabolic Disease and Bioinformatics, Evotec International GmbH, Hamburg, Germany., Radresa O; Metabolic Disease and Bioinformatics, Evotec International GmbH, Hamburg, Germany., Skroblin P; Metabolic Disease and Bioinformatics, Evotec International GmbH, Hamburg, Germany., Bayerlova M; Metabolic Disease and Bioinformatics, Evotec International GmbH, Hamburg, Germany., Unwin R; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vuilleumier N; Division of Laboratory Medicine, Diagnostics Department and Department of Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland., Banks RE; Leeds Institute of Medical Research at St James's, School of Medicine, University of Leeds, Leeds, UK (now Emerita position)., Braddon F; UK Renal Registry, Bristol, UK., Koziell A; Department of Experimental Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK.; Department of Paediatric Nephrology, Evelina London, Guy's and St Thomas' NHS Trust, London, UK., Taal MW; Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.; Department of Renal Medicine, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK., Welsh GI; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK., Saleem MA; Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK. |
| المصدر: | Clinical kidney journal [Clin Kidney J] 2024 Mar 30; Vol. 17 (8), pp. sfae096. Date of Electronic Publication: 2024 Mar 30 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101579321 Publication Model: eCollection Cited Medium: Print ISSN: 2048-8505 (Print) Linking ISSN: 20488505 NLM ISO Abbreviation: Clin Kidney J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Oxford University Press |
| مستخلص: | Background: Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics and design of clinical trials. Methods: NURTuRE-INS is a prospective cohort study of children and adults with INS in a linked biorepository. All recruits had at least one sampling visit collecting serum, plasma, urine and blood for RNA and DNA extraction, frozen within 2 hours of collection. Clinical histology slides and biopsy tissue blocks were also collected. Results: A total of 739 participants were recruited from 23 centres to NURTuRE-INS, half of whom were diagnosed in childhood [ n = 365 (49%)]. The majority were white [ n = 525 (71%)] and the median age at recruitment was 32 years (interquartile range 12-54). Steroid-sensitive nephrotic syndrome (SSNS) was the most common clinical diagnosis [ n = 518 (70%)]. Of patients diagnosed in childhood who underwent a kidney biopsy, for SSNS ( n =103), 76 demonstrated minimal change disease (MCD), whereas for steroid-resistant nephrotic syndrome ( n =80), 21 had MCD. Almost all patients diagnosed in adulthood had a kidney biopsy [ n = 352 (94%)]; 187 had MCD and 162 had focal segmental glomerulosclerosis. Conclusions: NURTuRE-INS is a prospective cohort study with high-quality biosamples and longitudinal data that will assist research into the mechanistic stratification of INS. Samples and data will be available through a Strategic Access and Oversight Committee. Competing Interests: M.W.T. reports consulting fees from Boehringer Ingelheim, honoraria and support to attend conferences from Bayer and a leadership role in the International Society of Nephrology. M.A.S. reports consulting fees from Travere and Purespring Therapeutics. R.E.B. reports grant funding and a patent with Randox Laboratories and support for attending meetings from Kidney Research UK. T.J. reports previous salary from UCB, consulting fees from UCB and Hybridize Therapeutics and shares in UCB. M.N reports a position on the QUOD Steering Committee. R.U. reports consulting fees from and stock in AstraZeneca and a leadership position in the Faculty of Pharmaceutical Medicine, Royal College of Physicians (London). The other authors declare that they have no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.) |
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| فهرسة مساهمة: | Keywords: biobank; focal segmental glomerulosclerosis; idiopathic nephrotic syndrome; minimal change disease |
| تواريخ الأحداث: | Date Created: 20240813 Latest Revision: 20240814 |
| رمز التحديث: | 20240814 |
| مُعرف محوري في PubMed: | PMC11317841 |
| DOI: | 10.1093/ckj/sfae096 |
| PMID: | 39135942 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2048-8505 |
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| DOI: | 10.1093/ckj/sfae096 |