دورية أكاديمية
أعرض في EDS

Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer.

التفاصيل البيبلوغرافية
العنوان: Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer.
المؤلفون: Yang J; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Li J; Shanxi Medical University, Taiyuan, 030001, China., Li S; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Yang Y; Shanxi Medical University, Taiyuan, 030001, China., Su H; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Guo H; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Lei J; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Wang Y; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Wen K; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Li X; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Zhang S; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. zsyprofessor@sxmu.edu.cn., Wang Z; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. wangzhe@sxmu.edu.cn.
المصدر: Molecular biomedicine [Mol Biomed] 2024 Aug 14; Vol. 5 (1), pp. 32. Date of Electronic Publication: 2024 Aug 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Singapore : Springer Singapore, [2020]-
مواضيع طبية MeSH: Endometrial Neoplasms*/genetics , Endometrial Neoplasms*/immunology , Endometrial Neoplasms*/pathology , Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Gene Expression Regulation, Neoplastic*, Humans ; Female ; Prognosis ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Transcriptome ; Genes, Homeobox/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Databases, Genetic ; Gene Expression Profiling ; Middle Aged
مستخلص: Endometrial cancer (UCEC) is one of three major malignant tumors in women. The HOX gene regulates tumor development. However, the potential roles of HOX in the expression mechanism of multiple cell types and in the development and progression of tumor microenvironment (TME) cell infiltration in UCEC remain unknown. In this study, we utilized both the The Cancer Genome Atlas (TCGA) database and International Cancer Genome Consortium (ICGC) database to analyze transcriptome data of 529 patients with UCEC based on 39 HOX genes, combing clinical information, we discovered HOX gene were a pivotal factor in the development and progression of UCEC and in the formation of TME diversity and complexity. Here, a new scoring system was developed to quantify individual HOX patterns in UCEC. Our study found that patients in the low HOX score group had abundant anti-tumor immune cell infiltration, good tumor differentiation, and better prognoses. In contrast, a high HOX score was associated with blockade of immune checkpoints, which enhances the response to immunotherapy. The Real-Time quantitative PCR (RT-qPCR) and Immunohistochemistry (IHC) exhibited a higher expression of the HOX gene in the tumor patients. We revealed that the significant upregulation of the HOX gene in the epithelial cells can activate signaling pathway associated with tumour invasion and metastasis through single-cell RNA sequencing (scRNA-seq), such as nucleotide metabolic proce and so on. Finally, a risk prognostic model established by the positive relationship between HOX scores and cancer-associated fibroblasts (CAFs) can predict the prognosis of individual patients by scRNA-seq and transcriptome data sets. In sum, HOX gene may serve as a potential biomarker for the diagnosis and prediction of UCEC and to develop more effective therapeutic strategies.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 2021M691995 China Postdoctoral Science Foundation; 202103021224394 The Natural Science Foundation of Shanxi Province; 201803D31111 The Shanxi Provincial Key Research and Development Project
فهرسة مساهمة: Keywords: HOX gene; Cancer-associated fibroblasts (CAFs); Endometrial cancer; Tumor microenvironment; scRNA-seq
المشرفين على المادة: 0 (Homeodomain Proteins)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240817
رمز التحديث: 20240817
مُعرف محوري في PubMed: PMC11322468
DOI: 10.1186/s43556-024-00196-w
PMID: 39138733
قاعدة البيانات: MEDLINE
الوصف
تدمد:2662-8651
DOI:10.1186/s43556-024-00196-w