دورية أكاديمية
Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer.
العنوان: | Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer. |
---|---|
المؤلفون: | Yang J; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Li J; Shanxi Medical University, Taiyuan, 030001, China., Li S; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Yang Y; Shanxi Medical University, Taiyuan, 030001, China., Su H; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Guo H; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Lei J; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Wang Y; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Wen K; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Li X; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China., Zhang S; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. zsyprofessor@sxmu.edu.cn., Wang Z; Department of Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. wangzhe@sxmu.edu.cn. |
المصدر: | Molecular biomedicine [Mol Biomed] 2024 Aug 14; Vol. 5 (1), pp. 32. Date of Electronic Publication: 2024 Aug 14. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Singapore : Springer Singapore, [2020]- |
مواضيع طبية MeSH: | Endometrial Neoplasms*/genetics , Endometrial Neoplasms*/immunology , Endometrial Neoplasms*/pathology , Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Gene Expression Regulation, Neoplastic*, Humans ; Female ; Prognosis ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Transcriptome ; Genes, Homeobox/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Databases, Genetic ; Gene Expression Profiling ; Middle Aged |
مستخلص: | Endometrial cancer (UCEC) is one of three major malignant tumors in women. The HOX gene regulates tumor development. However, the potential roles of HOX in the expression mechanism of multiple cell types and in the development and progression of tumor microenvironment (TME) cell infiltration in UCEC remain unknown. In this study, we utilized both the The Cancer Genome Atlas (TCGA) database and International Cancer Genome Consortium (ICGC) database to analyze transcriptome data of 529 patients with UCEC based on 39 HOX genes, combing clinical information, we discovered HOX gene were a pivotal factor in the development and progression of UCEC and in the formation of TME diversity and complexity. Here, a new scoring system was developed to quantify individual HOX patterns in UCEC. Our study found that patients in the low HOX score group had abundant anti-tumor immune cell infiltration, good tumor differentiation, and better prognoses. In contrast, a high HOX score was associated with blockade of immune checkpoints, which enhances the response to immunotherapy. The Real-Time quantitative PCR (RT-qPCR) and Immunohistochemistry (IHC) exhibited a higher expression of the HOX gene in the tumor patients. We revealed that the significant upregulation of the HOX gene in the epithelial cells can activate signaling pathway associated with tumour invasion and metastasis through single-cell RNA sequencing (scRNA-seq), such as nucleotide metabolic proce and so on. Finally, a risk prognostic model established by the positive relationship between HOX scores and cancer-associated fibroblasts (CAFs) can predict the prognosis of individual patients by scRNA-seq and transcriptome data sets. In sum, HOX gene may serve as a potential biomarker for the diagnosis and prediction of UCEC and to develop more effective therapeutic strategies. (© 2024. The Author(s).) |
References: | Tumour Biol. 2021;43(1):263-278. (PMID: 34633333) Cell Biol Toxicol. 2023 Aug;39(4):1577-1591. (PMID: 35982296) J Cancer. 2013;4(1):3-11. (PMID: 23386900) Mol Med. 2012 May 09;18:389-400. (PMID: 22160393) ESMO Open. 2022 Feb;7(1):100336. (PMID: 34953399) Cell Commun Signal. 2024 Mar 8;22(1):170. (PMID: 38459564) Front Mol Biosci. 2021 Nov 05;8:767856. (PMID: 34805277) Cell Death Dis. 2019 Apr 25;10(5):348. (PMID: 31024003) Nat Rev Cancer. 2010 May;10(5):361-71. (PMID: 20357775) Nature. 2009 Nov 5;462(7269):108-12. (PMID: 19847166) J Soc Gynecol Investig. 1998 Sep-Oct;5(5):277-80. (PMID: 9773404) Int J Mol Sci. 2023 Nov 01;24(21):. (PMID: 37958844) Br J Cancer. 2016 Oct 25;115(9):1147-1155. (PMID: 27727232) Nature. 1978 Dec 7;276(5688):565-70. (PMID: 103000) Bioinformatics. 2010 Jun 15;26(12):1572-3. (PMID: 20427518) Immunity. 2018 Mar 20;48(3):434-452. (PMID: 29562194) Oncoimmunology. 2021 Nov 22;10(1):2003533. (PMID: 34858727) Molecules. 2022 Mar 04;27(5):. (PMID: 35268795) Mol Cell Biol. 2019 Nov 12;39(23):. (PMID: 31527078) Cell Death Differ. 2015 Feb;22(2):237-46. (PMID: 25190142) Oncol Rep. 2005 Apr;13(4):721-6. (PMID: 15756448) Cancers (Basel). 2021 Jun 21;13(12):. (PMID: 34205678) J Cell Physiol. 2019 Jun;234(6):8509-8521. (PMID: 30520029) Clin Cancer Res. 2007 Nov 1;13(21):6327-34. (PMID: 17975144) Mol Ther Oncolytics. 2021 Feb 18;20:532-544. (PMID: 33738339) Vaccines (Basel). 2021 Oct 27;9(11):. (PMID: 34835178) Cancer Biomark. 2018;23(3):341-351. (PMID: 30223387) Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792) Signal Transduct Target Ther. 2021 Aug 20;6(1):313. (PMID: 34417435) Oncogene. 2015 Oct 16;34(42):5363-71. (PMID: 25619828) Cell Res. 2022 Jul;32(7):638-658. (PMID: 35459936) Genetics. 2022 Feb 4;220(2):. (PMID: 35137093) J Biol Chem. 2007 Jan 26;282(4):2615-25. (PMID: 17124180) Gut. 2022 Jan;71(1):129-147. (PMID: 33568427) Mol Ther. 2022 Aug 3;30(8):2800-2816. (PMID: 35526096) Cell Death Dis. 2018 May 3;9(5):509. (PMID: 29724991) Gastroenterology. 2022 Jun;162(7):1835-1837. (PMID: 35358506) Cell Rep. 2017 Jan 3;18(1):248-262. (PMID: 28052254) Breast Cancer. 2020 Sep;27(5):938-946. (PMID: 32297247) Front Immunol. 2021 Dec 07;12:781221. (PMID: 34950145) BMC Bioinformatics. 2013 Jan 16;14:7. (PMID: 23323831) Nature. 2017 Sep 20;549(7673):548-552. (PMID: 28959974) Nucleic Acids Res. 2016 May 5;44(8):e71. (PMID: 26704973) Cancer Res. 2004 May 1;64(9):3046-51. (PMID: 15126340) Mol Med Rep. 2017 Apr;15(4):1853-1862. (PMID: 28260072) PLoS One. 2015 Apr 14;10(4):e0124191. (PMID: 25875824) Cancer Lett. 2019 Jul 10;454:37-43. (PMID: 30978440) Development. 2003 May;130(10):2061-9. (PMID: 12668621) J Immunother Cancer. 2019 Aug 6;7(1):208. (PMID: 31387637) Front Immunol. 2021 Mar 24;12:648182. (PMID: 33841431) Tumour Biol. 2004 Sep-Dec;25(5-6):264-9. (PMID: 15627890) Int J Dev Biol. 2018;62(11-12):673-683. (PMID: 30604837) Nat Commun. 2013;4:2612. (PMID: 24113773) Nat Commun. 2017 Jan 16;8:14049. (PMID: 28091601) Int J Cancer. 2022 Jun 15;150(12):1919-1932. (PMID: 35080776) Nat Biotechnol. 2015 May;33(5):495-502. (PMID: 25867923) Sci Transl Med. 2020 Nov 4;12(568):. (PMID: 33148626) Eur J Pharmacol. 2014 Oct 5;740:364-78. (PMID: 25058905) |
معلومات مُعتمدة: | 2021M691995 China Postdoctoral Science Foundation; 202103021224394 The Natural Science Foundation of Shanxi Province; 201803D31111 The Shanxi Provincial Key Research and Development Project |
فهرسة مساهمة: | Keywords: HOX gene; Cancer-associated fibroblasts (CAFs); Endometrial cancer; Tumor microenvironment; scRNA-seq |
المشرفين على المادة: | 0 (Homeodomain Proteins) 0 (Biomarkers, Tumor) |
تواريخ الأحداث: | Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240817 |
رمز التحديث: | 20240817 |
مُعرف محوري في PubMed: | PMC11322468 |
DOI: | 10.1186/s43556-024-00196-w |
PMID: | 39138733 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2662-8651 |
---|---|
DOI: | 10.1186/s43556-024-00196-w |