دورية أكاديمية
Surgery for hepatoblastoma in children with trisomy 18: a monocentric study.
| العنوان: | Surgery for hepatoblastoma in children with trisomy 18: a monocentric study. |
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| المؤلفون: | Hirohara K; Department of Surgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan. h28md.hirohara@gmail.com., Tomita H; Department of Surgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Shimojima N; Department of Surgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan.; Division of Pediatric Surgery, Department of Pediatric Surgical Specialties, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan., Tsukizaki A; Department of Surgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Mori T; Department of Surgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Minegishi H; Department of Hematology and Oncology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Makimoto A; Department of Hematology and Oncology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Yuza Y; Department of Hematology and Oncology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Matsuoka K; Department of Pathology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan., Shimotakahara A; Department of Surgery, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan. |
| المصدر: | Pediatric surgery international [Pediatr Surg Int] 2024 Aug 14; Vol. 40 (1), pp. 223. Date of Electronic Publication: 2024 Aug 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8609169 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-9813 (Electronic) Linking ISSN: 01790358 NLM ISO Abbreviation: Pediatr Surg Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1986- |
| مواضيع طبية MeSH: | Hepatoblastoma*/genetics , Hepatoblastoma*/surgery , Trisomy 18 Syndrome*/complications , Trisomy 18 Syndrome*/genetics , Trisomy 18 Syndrome*/surgery , Liver Neoplasms*/surgery , Liver Neoplasms*/genetics, Humans ; Male ; Female ; Infant ; Child, Preschool ; Retrospective Studies ; Hepatectomy/methods ; Child ; Treatment Outcome ; Trisomy/genetics |
| مستخلص: | Purpose: Recently, children with trisomy 18 have been receiving more active treatment for malignancies. We report herein seven cases complete resection was achieved, and discuss multidisciplinary treatment for hepatoblastoma in patients with trisomy 18. Method: The medical records of children with trisomy 18 who were treated at the study center between 2010 and 2023 were reviewed. Result: Six of 69 patients had hepatoblastoma development, and three of these underwent multidisciplinary treatment. In addition, 6 patients had been referred by another hospital for treatment, and four of these underwent multidisciplinary treatment. Among the seven patients who underwent multidisciplinary treatment, three, two, and two were categorized in Pre-treatment Extent of Disease (PRETEXT) classification group I, II, and III, respectively. Neoadjuvant chemotherapy resulting in tumor reduction was performed in three cases. In all the cases, complete resection was achieved with pathologically safe margins. Perioperative complications included circulatory failure in one case and bile leakage in two cases. Adjuvant chemotherapy was administered in four cases. The postoperative observation period ranged from 3 months to 11 years, and all the patients are recurrence-free. Conclusion: Children with trisomy 18 complicated with hepatoblastoma whose cardiopulmonary conditions are stable may be good candidates for chemotherapy and surgery. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Children; Hepatoblastoma; Multidisciplinary treatment; Trisomy 18 |
| تواريخ الأحداث: | Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240814 |
| رمز التحديث: | 20240814 |
| DOI: | 10.1007/s00383-024-05813-x |
| PMID: | 39141149 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1437-9813 |
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| DOI: | 10.1007/s00383-024-05813-x |