دورية أكاديمية
أعرض في EDS

Exploration of microRNAs as transcriptional regulator in mumps virus infection through computational studies.

التفاصيل البيبلوغرافية
العنوان: Exploration of microRNAs as transcriptional regulator in mumps virus infection through computational studies.
المؤلفون: Hassan M; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Shahzadi S; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Iqbal MS; Department of Biochemistry, University of Okara, Okara, Pakistan., Yaseeen Z; Department of Biotechnology, Faculty of Science and Technology (FOST), University of Central Punjab, Johar Town, Lahore, Pakistan., Kloczkowski A; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA. kloczkowski.1@osu.edu.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA. kloczkowski.1@osu.edu.; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, 43210, USA. kloczkowski.1@osu.edu.
المصدر: Scientific reports [Sci Rep] 2024 Aug 14; Vol. 14 (1), pp. 18850. Date of Electronic Publication: 2024 Aug 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Mumps*/virology , Mumps*/genetics , Mumps virus*/genetics, Humans ; Computational Biology/methods ; Binding Sites ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Molecular Docking Simulation ; Gene Expression Regulation ; Female ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Male
مستخلص: Mumps is a common childhood infection caused by the mumps virus (MuV). Aseptic meningitis and encephalitis are usual symptoms of mumps together with orchitis and oophoritis that can arise in males and females, respectively. We have used computational tools: RNA22, miRanda and psRNATarget to predict the microRNA-mRNA binding sites to find the putative microRNAs playing role in the host response to mumps virus infection. Our computational studies indicate that hsa-mir-3155a is most likely involved in mumps infection. This was further investigated by the prediction of binding sites of hsa-mir-3155a to the MuV genome. Additionally, structure prediction using MC-Fold and MC-Sym, respectively has been applied to predict the 3D structures of miRNA and mRNA. The miRNA-mRNA interaction profile between has been confirmed through molecular docking simulation studies. Taken together, the putative miRNA (hsa_miR_6794_5p) has been found to be most likely involved in the regulation of transcriptional activity in the MuV infection.
(© 2024. The Author(s).)
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معلومات مُعتمدة: R01 GM127701 United States GM NIGMS NIH HHS; R01 HG012117 United States HG NHGRI NIH HHS
فهرسة مساهمة: Keywords: Docking studies; Mumps virus; RNA composer; RNA22; RStudio; miRBase; miRNA; miRanda; psRNATarget
المشرفين على المادة: 0 (MicroRNAs)
0 (RNA, Messenger)
0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240817
رمز التحديث: 20240817
مُعرف محوري في PubMed: PMC11324793
DOI: 10.1038/s41598-024-67717-z
PMID: 39143101
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-67717-z