دورية أكاديمية
Mitochondrial background can explain variable costs of immune deployment.
| العنوان: | Mitochondrial background can explain variable costs of immune deployment. |
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| المؤلفون: | Kutzer MAM; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Cornish B; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Jamieson M; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Zawistowska O; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Monteith KM; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Vale PF; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom. |
| المصدر: | Journal of evolutionary biology [J Evol Biol] 2024 Aug 27; Vol. 37 (9), pp. 1125-1133. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: England NLM ID: 8809954 Publication Model: Print Cited Medium: Internet ISSN: 1420-9101 (Electronic) Linking ISSN: 1010061X NLM ISO Abbreviation: J Evol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Oxford, UK : Blackwell Science Original Publication: [Basel, Switzerland : Birkhäuser Verlag, c1988- |
| مواضيع طبية MeSH: | Drosophila melanogaster*/immunology , Drosophila melanogaster*/genetics , Drosophila melanogaster*/microbiology , Mitochondria*/genetics , Longevity*, Animals ; Female ; Fertility |
| مستخلص: | Organismal health and survival depend on the ability to mount an effective immune response against infection. Yet immune defence may be energy-demanding, resulting in fitness costs if investment in immune function deprives other physiological processes of resources. While evidence of costly immunity resulting in reduced longevity and reproduction is common, the role of energy-producing mitochondria on the magnitude of these costs is unknown. Here, we employed Drosophila melanogaster cybrid lines, where several mitochondrial genotypes (mitotypes) were introgressed onto a single nuclear genetic background, to explicitly test the role of mitochondrial variation on the costs of immune stimulation. We exposed female flies carrying one of nine distinct mitotypes to either a benign, heat-killed bacterial pathogen (stimulating immune deployment while avoiding pathology) or to a sterile control and measured lifespan, fecundity, and locomotor activity. We observed mitotype-specific costs of immune stimulation and identified a positive genetic correlation in immune-stimulated flies between lifespan and the proportion of time cybrids spent moving while alive. Our results suggests that costs of immunity are highly variable depending on the mitochondrial genome, adding to a growing body of work highlighting the important role of mitochondrial variation in host-pathogen interactions. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Evolutionary Biology.) |
| معلومات مُعتمدة: | RPG-2018-369 Leverhulme Trust Research Project |
| فهرسة مساهمة: | Keywords: costs of immunity; host–parasite interaction; insects; life history evolution; mitochondria; trade-offs |
| تواريخ الأحداث: | Date Created: 20240815 Date Completed: 20240827 Latest Revision: 20240827 |
| رمز التحديث: | 20240828 |
| DOI: | 10.1093/jeb/voae082 |
| PMID: | 39145390 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1420-9101 |
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| DOI: | 10.1093/jeb/voae082 |