دورية أكاديمية
Pemuchiamides A and B, Proline-Rich Linear Lipopeptides, Isolated from a Marine Hormoscilla sp. Cyanobacterium.
| العنوان: | Pemuchiamides A and B, Proline-Rich Linear Lipopeptides, Isolated from a Marine Hormoscilla sp. Cyanobacterium. |
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| المؤلفون: | Irie K; Department of Applied Chemistry, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan., Jeelani G; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan., Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan., Iwasaki A; Department of Applied Chemistry, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. |
| المصدر: | Journal of natural products [J Nat Prod] 2024 Sep 27; Vol. 87 (9), pp. 2292-2301. Date of Electronic Publication: 2024 Aug 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Cyanobacteria*/chemistry , Marine Biology* , Trypanosoma brucei rhodesiense*/drug effects, Molecular Structure ; Japan ; Lipopeptides/pharmacology ; Lipopeptides/chemistry ; Lipopeptides/isolation & purification ; Nuclear Magnetic Resonance, Biomolecular ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/isolation & purification ; Proline/chemistry ; Proline/pharmacology ; Animals ; Trypanosomiasis, African/drug therapy |
| مستخلص: | Pemuchiamides A and B ( 1 and 2 ) were isolated from a marine Hormoscilla sp. cyanobacterium collected from Pemuchi Beach on Hateruma Island, Japan. Although 1 and 2 existed as a complex mixture of rotamers in chloroform- d , detailed analyses of their 2D NMR and tandem mass spectra revealed their planar structures, respectively. The absolute configurations of 1 and 2 were established via the degradation and derivatization reactions. Pemuchiamide A ( 1 ) exhibited potent growth-inhibitory activity against Trypanosoma brucei rhodesiense , the causative organism of African sleeping sickness, while 2 showed 10-fold weaker activity than 1 . This result indicates that the presence of a hydroxy group at the C-3 position of the 4-aminobutanoic acid moiety negatively affects antitrypanosomal activity. |
| المشرفين على المادة: | 0 (Lipopeptides) 0 (Trypanocidal Agents) 9DLQ4CIU6V (Proline) |
| تواريخ الأحداث: | Date Created: 20240815 Date Completed: 20240927 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| DOI: | 10.1021/acs.jnatprod.4c00733 |
| PMID: | 39145689 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/acs.jnatprod.4c00733 |