دورية أكاديمية
أعرض في EDS

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer.

التفاصيل البيبلوغرافية
العنوان: RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer.
المؤلفون: Liu Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China., Jiang Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China., Qiu P; Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China., Ma T; Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China., Bai Y; Department of Nursing, Shengjing Hospital of China Medical University, Shenyang, China., Bu J; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China., Hu Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China., Jin M; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China., Zhu T; Breast Surgery of Panjin Central Hospital, Panjin, China., Gu X; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
المصدر: ELife [Elife] 2024 Aug 15; Vol. 13. Date of Electronic Publication: 2024 Aug 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: RGS Proteins*/metabolism , RGS Proteins*/genetics , RGS Proteins*/deficiency , Epithelial-Mesenchymal Transition*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Neoplasm Metastasis* , Cell Movement*, Humans ; Cell Line, Tumor ; Female ; Prognosis
مستخلص: Distant metastasis is the major cause of death in patients with breast cancer. Epithelial-mesenchymal transition (EMT) contributes to breast cancer metastasis. Regulator of G protein-signaling (RGS) proteins modulates metastasis in various cancers. This study identified a novel role for RGS10 in EMT and metastasis in breast cancer. RGS10 protein levels were significantly lower in breast cancer tissues compared to normal breast tissues, and deficiency in RGS10 protein predicted a worse prognosis in patients with breast cancer. RGS10 protein levels were lower in the highly aggressive cell line MDA-MB-231 than in the poorly aggressive, less invasive cell lines MCF7 and SKBR3. Silencing RGS10 in SKBR3 cells enhanced EMT and caused SKBR3 cell migration and invasion. The ability of RGS10 to suppress EMT and metastasis in breast cancer was dependent on lipocalin-2 and MIR539-5p . These findings identify RGS10 as a tumor suppressor, prognostic biomarker, and potential therapeutic target for breast cancer.
Competing Interests: YL, YJ, PQ, TM, YB, JB, YH, MJ, TZ, XG No competing interests declared
(© 2024, Liu, Jiang, Qiu et al.)
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معلومات مُعتمدة: 82103468 National Natural Science Foundation of China; LJKMZ20221155 Basic research project for universities of Liaoning provincal department of education; M1953 Clinical trial Tree planting project of Shengjing Hospital of China Medical University
فهرسة مساهمة: Keywords: EMT; RGS10; breast cancer; cancer biology; human; metastasis; miRNA; mouse
سلسلة جزيئية: Dryad 10.5061/dryad.7h44j102r
المشرفين على المادة: 0 (RGS Proteins)
0 (RGS10 protein, human)
تواريخ الأحداث: Date Created: 20240815 Date Completed: 20240815 Latest Revision: 20240817
رمز التحديث: 20240817
مُعرف محوري في PubMed: PMC11326775
DOI: 10.7554/eLife.97327
PMID: 39145770
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.97327