دورية أكاديمية
The effects of iodine 131 treatment on chromosomal and oxidative DNA damage in papillary thyroid carcinoma.
| العنوان: | The effects of iodine 131 treatment on chromosomal and oxidative DNA damage in papillary thyroid carcinoma. |
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| المؤلفون: | Bitgen N; Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Bayram F; Department of Endocrinology and Metabolism, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Hamurcu Z; Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Baskol G; Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Ozturk F; Department of Pathology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Abdulrezzak U; Department of Nuclear Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Donmez-Altuntas H; Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey. Electronic address: donmezh@erciyes.edu.tr. |
| المصدر: | Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2024 Aug-Sep; Vol. 898, pp. 503797. Date of Electronic Publication: 2024 Jul 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101632149 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3592 (Electronic) Linking ISSN: 13835718 NLM ISO Abbreviation: Mutat Res Genet Toxicol Environ Mutagen Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, 1997- |
| مواضيع طبية MeSH: | Iodine Radioisotopes*/therapeutic use , Iodine Radioisotopes*/adverse effects , Thyroid Neoplasms*/blood , Thyroid Neoplasms*/radiotherapy , Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/genetics , DNA Damage* , Thyroid Cancer, Papillary*/blood , Thyroid Cancer, Papillary*/radiotherapy , Thyroidectomy* , Oxidative Stress*/drug effects, Humans ; Female ; Male ; Adult ; Middle Aged ; Micronucleus Tests ; Carcinoma, Papillary/blood ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/radiotherapy ; Carcinoma/radiotherapy ; Carcinoma/blood ; Carcinoma/genetics ; Lymphocytes/radiation effects ; Lymphocytes/drug effects ; 8-Hydroxy-2'-Deoxyguanosine/blood ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/blood ; Case-Control Studies ; Genomic Instability |
| مستخلص: | Papillary thyroid carcinoma (PTC) is a common endocrine cancer with a good prognosis. Radioactive iodine is thought to be useful for individuals who have had a total or almost total thyroidectomy, but its effects are still controversial. The effects of radioactive iodine-131 (I-131) treatment on oxidative and chromosomal damage in PTC patients were examined in this study, which was carried out with 16 patients newly diagnosed with PTC and 20 healthy control subjects with similar age and gender. Blood samples were taken from patients with PTC at five sampling times (before total thyroidectomy, after total thyroidectomy, and seven days, six months, and one year after treatment) and from control subjects. The cytokinesis block micronucleus cytome (CBMN-cyt) assay parameters in peripheral blood lymphocytes of patients with PTC and controls were evaluated and plasma 8-hydroxydeoxyguanosine (8-OHdG) levels were measured. Furthermore, genome instability and oxidative DNA damage in peripheral blood lymphocytes and plasma of patients with PTC were evaluated before total thyroidectomy (n=16), after total thyroidectomy (before I-131 treatment) (n=16), seven days (n=10), six months (n=5), and one year after treatment (n=5). The numbers of CBMN-cyt assay parameters (micronucleus; MN and nucleoplasmic bridges; NPB) and 8-OHdG levels in patients with PTC were determined to be significantly higher than in those of the control subjects and these values significantly decreased after total thyroidectomy (before I-131 treatment). While the number of MN, apoptotic, and necrotic cells increased after I-131 treatment, it significantly decreased after six months and one year after treatment. The results achieved in this study suggest that I-131 treatment may pose a threat to cells and that radioactive iodine therapy should be avoided (if possible) for patients with PTC after total thyroidectomy. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cytome assay; Micronucleus; Oxidative stress; Papillary thyroid carcinoma; Radioactive iodine-131 |
| المشرفين على المادة: | 0 (Iodine Radioisotopes) 0 (Iodine-131) 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine) G9481N71RO (Deoxyguanosine) |
| تواريخ الأحداث: | Date Created: 20240815 Date Completed: 20240815 Latest Revision: 20240815 |
| رمز التحديث: | 20240816 |
| DOI: | 10.1016/j.mrgentox.2024.503797 |
| PMID: | 39147446 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3592 |
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| DOI: | 10.1016/j.mrgentox.2024.503797 |