دورية أكاديمية
Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing.
| العنوان: | Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing. |
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| المؤلفون: | Thomas RE; Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montréal, Québec H3G 1A4, Canada.; Departments of Neurology and Neurosurgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Pediatrics, McGill University, Montréal, Québec H3G 1A4, Canada.; Integrated Program in Neuroscience, McGill University, Montréal, Québec H3A 1A1, Canada., Mudlaff F; Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montréal, Québec H3G 1A4, Canada.; Departments of Neurology and Neurosurgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Pediatrics, McGill University, Montréal, Québec H3G 1A4, Canada.; Integrated Program in Neuroscience, McGill University, Montréal, Québec H3A 1A1, Canada., Schweers K; Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montréal, Québec H3G 1A4, Canada.; Departments of Neurology and Neurosurgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Pediatrics, McGill University, Montréal, Québec H3G 1A4, Canada., Farmer WT; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599., Suvrathan A; Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montréal, Québec H3G 1A4, Canada aparna.suvrathan@mcgill.ca.; Departments of Neurology and Neurosurgery, McGill University, Montréal, Québec H3G 1A4, Canada.; Pediatrics, McGill University, Montréal, Québec H3G 1A4, Canada. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Sep 11; Vol. 44 (37). Date of Electronic Publication: 2024 Sep 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Purkinje Cells*/physiology , Synaptic Transmission*/physiology , Mice, Inbred C57BL*, Animals ; Mice ; Male ; Female ; Cerebellum/physiology ; Cerebellum/cytology ; Excitatory Postsynaptic Potentials/physiology ; Synapses/physiology ; Time Factors ; Action Potentials/physiology |
| مستخلص: | The cerebellum plays an important role in diverse brain functions, ranging from motor learning to cognition. Recent studies have suggested that molecular and cellular heterogeneity within cerebellar lobules contributes to functional differences across the cerebellum. However, the specific relationship between molecular and cellular heterogeneity and diverse functional outputs of different regions of the cerebellum remains unclear. Here, we describe a previously unappreciated form of synaptic heterogeneity at parallel fiber synapses to Purkinje cells in the mouse cerebellum (both sexes). In contrast to uniform fast synaptic transmission, we found that the properties of slow synaptic transmission varied by up to threefold across different lobules of the mouse cerebellum, resulting in surprising heterogeneity. Depending on the location of a Purkinje cell, the time of peak of slow synaptic currents varied by hundreds of milliseconds. The duration and decay time of these currents also spanned hundreds of milliseconds, based on lobule. We found that, as a consequence of the heterogeneous synaptic dynamics, the same brief input stimulus was transformed into prolonged firing patterns over a range of timescales that depended on Purkinje cell location. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Thomas et al.) |
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| فهرسة مساهمة: | Keywords: Purkinje cell; cerebellum; metabotropic glutamate receptor; synapse |
| تواريخ الأحداث: | Date Created: 20240815 Date Completed: 20240911 Latest Revision: 20240914 |
| رمز التحديث: | 20240914 |
| مُعرف محوري في PubMed: | PMC11391503 |
| DOI: | 10.1523/JNEUROSCI.0455-24.2024 |
| PMID: | 39147589 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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| DOI: | 10.1523/JNEUROSCI.0455-24.2024 |