دورية أكاديمية
Acceleration of Final Residual Solvent Extraction From Poly(lactide-co-glycolide) Microparticles.
| العنوان: | Acceleration of Final Residual Solvent Extraction From Poly(lactide-co-glycolide) Microparticles. |
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| المؤلفون: | Kias F; College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169, Berlin, Germany., Bodmeier R; College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169, Berlin, Germany. bodmeier@zedat.fu-berlin.de. |
| المصدر: | Pharmaceutical research [Pharm Res] 2024 Sep; Vol. 41 (9), pp. 1869-1879. Date of Electronic Publication: 2024 Aug 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers Original Publication: Stuttgart ; New York : Thieme, c1984- |
| مواضيع طبية MeSH: | Solvents*/chemistry , Methylene Chloride*/chemistry , Dexamethasone*/chemistry , Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry, Particle Size ; Risperidone/chemistry ; Lactic Acid/chemistry ; Polyglycolic Acid/chemistry ; Drug Compounding/methods ; Microspheres |
| مستخلص: | Purpose: The removal of the residual solvent dichloromethane from biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles was investigated by aqueous or alcoholic wet extraction or vacuum-drying. Methods: Microparticles were prepared by the O/W solvent extraction/evaporation method. The solidified microparticles were separated by filtration and the effect of subsequent drying and wet extraction methods were investigated. The residual solvent content was analysed with gas chromatography (organic solvents) and Karl Fischer titration (water). The effect of extraction conditions on microparticle aggregation, surface morphology and encapsulation of the drugs dexamethasone and risperidone was investigated. Results: Residual dichloromethane was reduced to 2.43% (w/w) (20 °C) or 0.03% (w/w) (35 °C) by aqueous wet extraction. With vacuum-drying, residual dichloromethane only decreased from about 5% (w/w) to 4.34% (w/w) (20 °C) or 3.20% (w/w) (35 °C) due to the lack of the plasticizing effect of water. Redispersion of filtered, wet microparticles in alcoholic media significantly improved the extraction due to an increased PLGA plasticization. The potential of different extractants was explained with the Gordon-Taylor equation and Hansen solubility parameters. Extraction in methanol: or ethanol:water mixtures reduced residual dichloromethane from 4 - 7% (w/w) to 0.5 - 2.3% (w/w) within 1 h and 0.08 - 0.18% (w/w) within 6 h. Higher alcohol contents and higher temperature resulted in aggregation of microparticles and lower drug loadings. Conclusion: The final removal of residual dichloromethane was more efficient with alcoholic wet extraction followed by aqueous wet extraction at elevated temperature and vacuum drying of the microparticles. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: microparticles; plasticization; poly(lactide-co-glycolide); solvent extraction; solvent residuals |
| المشرفين على المادة: | 0 (Solvents) 588X2YUY0A (Methylene Chloride) 7S5I7G3JQL (Dexamethasone) 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) L6UH7ZF8HC (Risperidone) 33X04XA5AT (Lactic Acid) 26009-03-0 (Polyglycolic Acid) |
| تواريخ الأحداث: | Date Created: 20240815 Date Completed: 20240927 Latest Revision: 20240927 |
| رمز التحديث: | 20240927 |
| DOI: | 10.1007/s11095-024-03744-9 |
| PMID: | 39147990 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-904X |
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| DOI: | 10.1007/s11095-024-03744-9 |