دورية أكاديمية
أعرض في EDS

Predictors of functional mitral regurgitation improvement in patients with left bundle branch block treated with left bundle branch area pacing.

التفاصيل البيبلوغرافية
العنوان: Predictors of functional mitral regurgitation improvement in patients with left bundle branch block treated with left bundle branch area pacing.
المؤلفون: Miao H; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Chen Z; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Luo Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Cheng Y; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Cooray PLRK; School of International Education, Nanjing Medical University, Nanjing, Jiangsu, China., Wu T; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Yang W; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Zhou X; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Shan Q; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Jiang Z; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
المصدر: Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2024 Aug 16. Date of Electronic Publication: 2024 Aug 16.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Futura Pub. Co. Country of Publication: United States NLM ID: 7803944 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8159 (Electronic) Linking ISSN: 01478389 NLM ISO Abbreviation: Pacing Clin Electrophysiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Mount Kisco, N. Y. : Futura Pub. Co., c1978-
مستخلص: Background: Functional mitral regurgitation (FMR) and its severity are associated with adverse outcomes in heart failure patients. This study aims to analyze the predictors of FMR improvement after successful left bundle branch area pacing (LBBAP) in patients with LVEF < 50% and complete left bundle branch block (CLBBB).
Methods: Consecutive patients with LVEF < 50% and CLBBB who underwent successful LBBAP from July 2018 to July 2023 were retrospectively identified. Significant MR was defined as regurgitation of moderate severity or greater. Patients with significant FMR were included in the analysis. FMR improvement (FMRI) was defined as a reduction of at least one grade in regurgitation severity compared to baseline at 3 months or longer follow-up.
Results: Among the 81 identified patients, 42 patients with significant FMR preoperatively were included. After LBBAP, QRS duration significantly shortened from 170.6 ± 18.8 ms to 114.5 ± 20.2 ms (p < .001). Significant FMR improves in approximately 76.2%, and the patients were divided into an FMRI group (n = 32) and a non-FMRI group (n = 10). Univariate analysis showed that absence of persistent atrial fibrillation, typical CLBBB, and left atrium diameter at baseline were associated with improvement of FMR after LBBAP. Of these variables, only absence of persistent atrial fibrillation remains an independent predictor in the multivariate model (OR 12.436, p = .009).
Conclusion: LBBAP is able to improve FMR in heart failure patients who had CLBBB with LVEF < 50%. Meanwhile, the absence of persistent atrial fibrillation is an independent predictor of FMR improvement.
(© 2024 Wiley Periodicals LLC.)
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معلومات مُعتمدة: 82370387 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: atrial fibrillation; functional mitral regurgitation; heart failure; left bundle branch area pacing; left bundle branch block
تواريخ الأحداث: Date Created: 20240816 Latest Revision: 20240816
رمز التحديث: 20240816
DOI: 10.1111/pace.15059
PMID: 39150019
قاعدة البيانات: MEDLINE
الوصف
تدمد:1540-8159
DOI:10.1111/pace.15059