دورية أكاديمية
أعرض في EDS

Comparison of Clinical and Genetic Characteristics of Familial Mediterranean Fever Patients Among Adult Age Groups.

التفاصيل البيبلوغرافية
العنوان: Comparison of Clinical and Genetic Characteristics of Familial Mediterranean Fever Patients Among Adult Age Groups.
المؤلفون: Fidan S; Department of Gastroenterology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Seferli S; Department of Internal Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Durak S; Department of Gastroenterology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Konca Seferoğlu C; Department of Gastroenterology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Okatan İE; Department of Rheumatology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Çebi AH; Department of Medical Genetics, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Erkut M; Department of Gastroenterology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye., Coşar AM; Department of Gastroenterology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye.
المصدر: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2024 May 20; Vol. 35 (8), pp. 618-624.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: Aves Country of Publication: Turkey NLM ID: 9515841 Publication Model: Print Cited Medium: Internet ISSN: 2148-5607 (Electronic) Linking ISSN: 13004948 NLM ISO Abbreviation: Turk J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : İstanbul,Turkey : Aves
Original Publication: Ankara : Turkish Society of Gastroenterology, 1995-
مواضيع طبية MeSH: Familial Mediterranean Fever*/genetics , Mutation* , Pyrin*/genetics , Age of Onset*, Humans ; Adult ; Male ; Female ; Middle Aged ; Young Adult ; Adolescent ; Aged ; Turkey/epidemiology ; Abdominal Pain/etiology ; Amyloidosis/genetics ; Homozygote ; Heterozygote
مستخلص: Familial mediterranean fever (FMF) is a genetic autoinflammatory disease typically diagnosed in childhood. In this study, we aimed to investigate the demographic, clinical, and genetic characteristics of patients aged 18 years and older who were diagnosed with FMF. Patients diagnosed with FMF between 2014 and 2022 at Karadeniz Technical University Faculty of Medicine Hospital were included in the study. Patients were divided into 2 groups based on the age of disease onset. Group I included patients with adult-onset (ages 18-40), while group II comprised patients with late onset (ages 40 and above). Subsequently, the 2 groups were compared. A total of 150 patients with a mean age of 32 (18-79) were included in the study. There were 116 patients in group I and 34 (22.7%) in group II. The most common presenting complaint was abdominal pain (91.3%), and the most prevalent complication was amyloidosis (4.7%). No significant differences were observed between age groups regarding clinical findings and symptoms. The most frequent homozygous mutations were M694V (9.3%) and R202Q (1.8%), while the heterozygous mutations were M694V (37.3%) and R202Q (35.5%), respectively. The rate of M694V gene positivity in the adult-onset group was significantly higher compared to the lateonset group (52.9% and 25%, respectively, P = .020). There does not appear to be a significant difference in clinical signs and symptoms between adult-onset and late-onset FMF patients. The higher rate of M694V gene positivity in the adult-onset group suggests that the M694V mutation may be responsible for the early expression of the disease.
المشرفين على المادة: 0 (Pyrin)
0 (MEFV protein, human)
تواريخ الأحداث: Date Created: 20240816 Date Completed: 20240816 Latest Revision: 20240816
رمز التحديث: 20240816
DOI: 10.5152/tjg.2024.23662
PMID: 39150338
قاعدة البيانات: MEDLINE
الوصف
تدمد:2148-5607
DOI:10.5152/tjg.2024.23662