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Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence.

التفاصيل البيبلوغرافية
العنوان: Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence.
المؤلفون: Tschorn M; Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany.; German Center for Mental Health (DZPG), Berlin and Potsdam, Germany., Daedelow L; German Center for Mental Health (DZPG), Berlin and Potsdam, Germany.; Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.; Department of Psychology, Humboldt-University Berlin, Germany., Szalek L; Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany., Banaschewski T; German Center for Mental Health (DZPG), Berlin and Potsdam, Germany.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Bokde ALW; Discipline of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland., Desrivières S; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic, and Developmental Psychiatry Centre, King's College London, London, United Kingdom., Flor H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany., Grigis A; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France., Garavan H; Department of Psychiatry, University of Vermont, Burlington.; Department of Psychology, University of Vermont, Burlington., Gowland P; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom., Martinot JL; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 Trajectoires Développementales & Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Centre Borelli, University Paris Saclay, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France., Martinot MP; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 Trajectoires Développementales & Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Centre Borelli, University Paris Saclay, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.; Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris Sorbonne University, Paris, France., Artiges E; Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure Paris-Saclay, University Paris Saclay, Centre Borelli, CNRS, and Psychiatry Department, Établissement Public de Santé Barthélémy Durand, Etampes, France., Nees F; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany., Orfanos DP; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France., Poustka L; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany., Hohmann S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Buechl C; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany., Smolka MN; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany., Vaidya N; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany., Walter H; Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Whelan R; School of Psychology, Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Schumann G; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, China., Heinz A; German Center for Mental Health (DZPG), Berlin and Potsdam, Germany.; Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Rapp MA; Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany.; German Center for Mental Health (DZPG), Berlin and Potsdam, Germany.
مؤلفون مشاركون: IMAGEN Consortium
المصدر: JAMA network open [JAMA Netw Open] 2024 Aug 01; Vol. 7 (8), pp. e2425114. Date of Electronic Publication: 2024 Aug 01.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chicago, IL : American Medical Association, [2018]-
مواضيع طبية MeSH: Alcoholism*/epidemiology , Alcoholism*/psychology , Personality*, Humans ; Adolescent ; Male ; Female ; Longitudinal Studies ; Risk Factors ; Brain/diagnostic imaging ; Young Adult ; Underage Drinking/statistics & numerical data ; Underage Drinking/psychology ; Adolescent Behavior/psychology ; Risk-Taking ; Europe/epidemiology
مستخلص: Importance: The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures.
Objective: To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years.
Design, Setting, and Participants: The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022.
Exposure: Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse.
Main Outcome and Measures: Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models.
Results: A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model.
Conclusions and Relevance: The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.
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فهرسة مساهمة: Investigator: T Robbin; J Dalley; N Subramaniam; D Theobald; K Mann; C Bach; M Struve; M Rietschel; R Spanagel; M Fauth-Bühler; S Millenet; Y Grimmer; M Lathrop; L Albrecht; N Ivanov; N Strache; A Ströhle; J Reuter; J Gallinat; I Gemmeke; A Genauck; C Parchetka; K Weiß; J Kruschwitz; B Raffaelli; A Barbot; B Thyreau; Y Schwartz; C Lalanne; VF Frouin; J Rogers; J Ireland; D Lanzerath; J Feng; Z Bricaud; F Gollier Briand; H LemaÎtre; R Miranda; J Massicotte; H Vulser; J Pentillä; I Filippi; A Galinowski; P Bezivin; A Cattrell; T Jia; H Werts; L Topper; L Reed; C Andrew; C Mallik; B Ruggeri; G Barker; C Nymberg; PJ Conrod; L Smith; E Loth; S Havatzias; E Kitson; A Robinson; D Hall; C Rubino; H Wright; K Stueber; E Hanratty; E Kennedy; FM de Carvahlo; A Stringaris; A Ing; G Robert; C Macare; B Xu; T Yu; E Burke Quinlan; P Constant; S Aydin; R Brühl; A Ihlenfeld; B Walaszek; B Ittermann; M Smolka; T Hübner; K Müller; S Ripke; S Jurk; E Mennigen; D Schmidt; N Vetter; V Ziesch; JH Fröhner; D Carter; S O'Driscoll; E Walsh; MLF Agan; M McMorrow; S Nugent; C Connolly; E Dooley; C Cremen; J Jones; J O'Keefe; M O'Connor; JB Poline; U Bromberg; T Fadai; J Yacubian; S Schneider; M Lobatcheva; C Lawrence; C Newman; K Head; A Stedman; N Heym; M Kaviani; T Paus; D Stephens; Z Pausova; A Tahmasebi
تواريخ الأحداث: Date Created: 20240816 Date Completed: 20240816 Latest Revision: 20240819
رمز التحديث: 20240819
مُعرف محوري في PubMed: PMC11329879
DOI: 10.1001/jamanetworkopen.2024.25114
PMID: 39150713
قاعدة البيانات: MEDLINE
الوصف
تدمد:2574-3805
DOI:10.1001/jamanetworkopen.2024.25114