دورية أكاديمية
Long-term impact of rotavirus vaccination on all-cause and rotavirus-specific gastroenteritis and strain distribution in Central Kenya: An 11-year interrupted time-series analysis.
| العنوان: | Long-term impact of rotavirus vaccination on all-cause and rotavirus-specific gastroenteritis and strain distribution in Central Kenya: An 11-year interrupted time-series analysis. |
|---|---|
| المؤلفون: | Wandera EA; Centre for Virus Research, Kenya Medical Research Institute, P.O. Box 54840-00200, Nairobi, Kenya,; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya,. Electronic address: ewandera@kemri.go.ke., Kurokawa N; Department of Project Planning and Management, Mitsubishi Tanabe Pharma Corporation, 1-1-1, Marunouchi Chiyoda-ku, Tokyo 100-8205, Japan., Mutua MM; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Muriithi B; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Nyangao J; Centre for Virus Research, Kenya Medical Research Institute, P.O. Box 54840-00200, Nairobi, Kenya., Khamadi SA; Centre for Virus Research, Kenya Medical Research Institute, P.O. Box 54840-00200, Nairobi, Kenya., Kathiiko C; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Wachira M; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Njuguna E; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Mwaura B; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Golicha RO; Centre for Microbiology Research, Kenya Medical Research Institute, P.O. Box 54840-00200 Nairobi, Kenya., Njau J; Department of Pediatrics, Kiambu County Teaching and Referral Hospital, P.O. Box 39-00900 Kiambu, Kenya., Morita K; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Kaneko S; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya., Komoto S; Department of Virology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho,Toyoake, Aichi 470-1192, Japan,; Division of One Health, Research Center for Global and Local Infectious Diseases, 1-1 Idaigaoka, Hasama-machi, Oita University, Yufu 879-5593, Oita, Japan., Tsutsui N; Department of Project Planning and Management, Mitsubishi Tanabe Pharma Corporation, 1-1-1, Marunouchi Chiyoda-ku, Tokyo 100-8205, Japan., Ichinose Y; Institute of Tropical Medicine, Nagasaki University, P.O. Box 19993-00202, Nairobi, Kenya. |
| المصدر: | Vaccine [Vaccine] 2024 Sep 17; Vol. 42 (22), pp. 126210. Date of Electronic Publication: 2024 Aug 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam, The Netherlands : Elsevier Science Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983- |
| مواضيع طبية MeSH: | Rotavirus Vaccines*/administration & dosage , Rotavirus Vaccines*/immunology , Rotavirus Infections*/prevention & control , Rotavirus Infections*/epidemiology , Gastroenteritis*/epidemiology , Gastroenteritis*/virology , Gastroenteritis*/prevention & control , Rotavirus*/immunology , Rotavirus*/genetics , Immunization Programs* , Interrupted Time Series Analysis* , Vaccination*/statistics & numerical data, Humans ; Kenya/epidemiology ; Child, Preschool ; Infant ; Hospitalization/statistics & numerical data ; Female ; Feces/virology ; Male ; Genotype ; Vaccines, Attenuated/immunology ; Vaccines, Attenuated/administration & dosage |
| مستخلص: | Background: Kenya introduced a monovalent rotavirus vaccine administered orally at 6 and 10 weeks of age into her National Immunization Program in July 2014. The study evaluated the long-term impact of the vaccine on hospitalization for all-cause and rotavirus-specific acute gastroenteritis (AGE) and strain epidemiology in Kenya. Methods: Data on all-cause and rotavirus-specific AGE and strain distribution were derived from an eleven-year hospital-based surveillance of AGE among children aged <5 years at Kiambu County Teaching and Referral Hospital (KCTRH) in Central Kenya between 2009 and 2020. Fecal samples were screened for group A rotavirus using ELISA and genotyped using multiplex semi-nested RT-PCR. Trends in all-cause and rotavirus-related AGE and strain distribution were compared between the pre-vaccine (July 2009-June 2014), early post-vaccine (July 2014-June 2016) and late post-vaccine (February 2019-October 2020) periods. Results: Rotavirus-specific AGE was detected at 27.5% (429/1546, 95% CI: 25.5-30.1%) in the pre-vaccine period; 13.8% (91/658, 95% CI: 11.3-16.6%) in the early post-vaccine period (July 2014-June 2016); and 12.0% (229/1916, 95% CI: 10.6-13.5%) in the late post-vaccine period (February 2019-October 2020). This amounted to a decline of 49.8% (95% CI: 34.6%-63.7%) in rotavirus-specific AGE in the early post-vaccine period and 53.4% (95% CI: 41.5-70.3%) in the late post-vaccine period when compared to the pre-vaccine period. All-cause AGE hospitalizations declined by 40.2% (95% CI: 30.8%-50.2%) and 75.3% (95% CI: 65.9-83.1%) in the early post-vaccine and late post-vaccine periods, respectively, when compared to the pre-vaccine period. G3P [8] was the predominant strain in the late post-vaccine period, replacing G1P[8] which had predominated in the pre-vaccine and early post-vaccine periods. Additionally, we detected considerable proportions of uncommon strains G3P[6] (4.8%) and G12P[6] (3.5%) in the post-vaccine era. Conclusion: Rotavirus vaccination has resulted in a significant decline in all-cause and rotavirus-specific AGE, and thus, provides strong evidence for public health policy makers in Kenya to support the sustained use of the rotavirus vaccine in routine immunization. However, the shift in strain dominance and age distribution of rotavirus AGE in the post-vaccine era underscores the need for continued surveillance to assess any possible vaccine-induced selective pressure that could diminish the vaccine effectiveness over time. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Coverage; Gastroenteritis; Kenya; Rotavirus; Strains; Vaccine impact |
| المشرفين على المادة: | 0 (Rotavirus Vaccines) 0 (Vaccines, Attenuated) |
| تواريخ الأحداث: | Date Created: 20240816 Date Completed: 20240902 Latest Revision: 20240902 |
| رمز التحديث: | 20240903 |
| DOI: | 10.1016/j.vaccine.2024.126210 |
| PMID: | 39151233 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-2518 |
|---|---|
| DOI: | 10.1016/j.vaccine.2024.126210 |