دورية أكاديمية
Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes.
| العنوان: | Toxicological assays in the evaluation of safety assessment of fibrinolytic enzymes. |
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| المؤلفون: | Marques da Silva M; Laboratório de Avanços em Biotecnologia de Proteínas e Tecnologia de Bioativos, Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brasil., Santana Moura YA; Laboratório de Avanços em Biotecnologia de Proteínas e Tecnologia de Bioativos, Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brasil., Leite AHP; Departamento de Bioquímica, Centro Universitário de Patos - UNIFIP, Patos, Paraíba, Brasil., Souza KLDS; Instituto Ciências Biológicas, Universidade de Pernambuco, Recife, Pernambuco, Brasil., Brandão Costa RMP; Instituto Ciências Biológicas, Universidade de Pernambuco, Recife, Pernambuco, Brasil., Nascimento TP; Campus Professora Cinobelina Elvas, Universidade Federal do Piauí, Bom Jesus, Piauí, Brasil., Porto ALF; Laboratório de Avanços em Biotecnologia de Proteínas e Tecnologia de Bioativos, Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brasil., Bezerra RP; Laboratório de Avanços em Biotecnologia de Proteínas e Tecnologia de Bioativos, Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brasil. |
| المصدر: | Drug and chemical toxicology [Drug Chem Toxicol] 2024 Aug 19, pp. 1-11. Date of Electronic Publication: 2024 Aug 19. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Group Original Publication: New York, Dekker. |
| مستخلص: | Cardiovascular diseases (CVDs) cause 30% of deaths each year, and in 2030, around 23.6 million people will die due to CVDs. The major challenge is to obtain molecules with minimal adverse reactions that can prevent and dissolve blood clots. In this context, fibrinolytic enzymes from diverse microorganism sources have been extensively investigated due to their potential to act directly and specifically on the fibrin clot, preventing side effects and performing potential thrombolytic effects. However, most researches focus on the purification and characterization of proteases, with little emphasis on the mechanism of action and pharmacological characteristics, including toxicity assays which are essential to assess safety and side effects. Therefore, this work aims to emphasize the importance of evaluations indicating the toxicological profile of fibrinolytic proteases through in vitro and in vivo tests. Both types of assays contribute as preclinical stage in drug development and are crucial for clinical applications. This scarcity creates arbitrary barriers to further studies. This work should further encourage the development of studies to ensure the safety and effectivity of fibrinolytic proteases. |
| فهرسة مساهمة: | Keywords: Toxicity; biocompatibility; biological applications; proteases; thrombolytic therapy Local Abstract: [plain-language-summary] Suggested pre-clinical trials aim to validate more specific methods for fibrinolytic enzymes;Current toxicity standards can be adapted to better assess the profile of fibrinolytic enzymes;The class of fibrinolytic enzymes must be carefully evaluated according to the method of application. |
| تواريخ الأحداث: | Date Created: 20240819 Latest Revision: 20240819 |
| رمز التحديث: | 20240819 |
| DOI: | 10.1080/01480545.2024.2367561 |
| PMID: | 39155645 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1525-6014 |
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| DOI: | 10.1080/01480545.2024.2367561 |