دورية أكاديمية
Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study.
| العنوان: | Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study. |
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| المؤلفون: | Mboumba Bouassa RS; Department of Biological Sciences and CERMO-FC Research Centre, Université du Quebec à Montréal, Montreal, QC, Canada.; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Giorgini G; Research Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval., Silvestri C; Research Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.; Institut sur la Nutrition et les Aliments Fonctionnels (INAF) et Centre Nutrition, Santé et Société (NUTRISS), Université Laval, Québec City, QC, Canada., Muller C; Research Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval., Nallabelli N; Research Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval., Alexandrova Y; Department of Biological Sciences and CERMO-FC Research Centre, Université du Quebec à Montréal, Montreal, QC, Canada., Durand M; Centre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada., Tremblay C; Centre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada., El-Far M; Centre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada., Chartrand-Lefebvre C; Centre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada., Messier-Peet M; Centre de recherche du CHUM, Université de Montréal, Montreal, QC, Canada., Margolese S; CIHR Canadian HIV Trials Network (CTN), Vancouver, BC, Canada., Flamand N; Research Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval., Costiniuk CT; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; Division of Infectious Diseases/Chronic Viral Illness Service, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada., Di Marzo V; Research Center of the Institut Universitaire de Cardiologie et Pneumologie de Québec (CRIUCPQ), Université Laval.; Institut sur la Nutrition et les Aliments Fonctionnels (INAF) et Centre Nutrition, Santé et Société (NUTRISS), Université Laval, Québec City, QC, Canada.; Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval., Jenabian MA; Department of Biological Sciences and CERMO-FC Research Centre, Université du Quebec à Montréal, Montreal, QC, Canada. |
| المصدر: | IScience [iScience] 2024 Jul 05; Vol. 27 (8), pp. 110456. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
| مستخلص: | Chronic HIV infection is associated with accelerated coronary artery disease (CAD) due to chronic inflammation. The expanded endocannabinoid system (eCBome) and gut microbiota modulate each other and are key regulators of cardiovascular functions and inflammation. We herein investigated the interplay between plasma eCBome mediators and gut microbiota in people with HIV (PWH) and/or subclinical CAD versus HIV-uninfected individuals. CAD was determined by coronary computed tomography (CT) angiography performed on all participants. Plasma eCBome mediator and fecal microbiota composition were assessed by tandem mass spectrometry and 16S rDNA sequencing, respectively. HIV infection was associated with perturbed plasma eCBome mediators characterized by an inverse relationship between anandamide and N -acyl-ethanolamines (NAEs) versus 2-AG and 2-monoacylglycerols (MAGs). Plasma triglyceride levels were positively associated with MAGs. Several fecal bacterial taxa were altered in HIV-CAD+ versus controls and correlated with plasma eCBome mediators. CAD-associated taxonomic alterations in fecal bacterial taxa were not found in PWH. Competing Interests: We have no competing interest to declare. (© 2024 The Author(s).) |
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| معلومات مُعتمدة: | R01 AG054324 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: Cardiovascular medicine; Health sciences; Immunology; Medical specialty; Medicine |
| تواريخ الأحداث: | Date Created: 20240819 Latest Revision: 20240830 |
| رمز التحديث: | 20240830 |
| مُعرف محوري في PubMed: | PMC11326910 |
| DOI: | 10.1016/j.isci.2024.110456 |
| PMID: | 39156649 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2589-0042 |
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| DOI: | 10.1016/j.isci.2024.110456 |