دورية أكاديمية
Rationalising the dose threshold for severe carbamazepine toxicity: a retrospective series.
| العنوان: | Rationalising the dose threshold for severe carbamazepine toxicity: a retrospective series. |
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| المؤلفون: | Harris K; Clinical Toxicology Unit, Princess Alexandra Hospital, Brisbane, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Poisons Information Centre, Queensland Children's Hospital, Brisbane, Queensland, Australia., Dalton B; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Poisons Information Centre, Queensland Children's Hospital, Brisbane, Queensland, Australia., Learmont BG; Clinical Toxicology Unit, Princess Alexandra Hospital, Brisbane, Australia., Isoardi KZ; Clinical Toxicology Unit, Princess Alexandra Hospital, Brisbane, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Queensland Poisons Information Centre, Queensland Children's Hospital, Brisbane, Queensland, Australia. |
| المصدر: | Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2024 Aug; Vol. 62 (8), pp. 533-535. Date of Electronic Publication: 2024 Aug 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101241654 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-9519 (Electronic) Linking ISSN: 15563650 NLM ISO Abbreviation: Clin Toxicol (Phila) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Philadelphia, PA : Taylor & Francis, c2005- |
| مواضيع طبية MeSH: | Carbamazepine*/poisoning , Carbamazepine*/administration & dosage , Seizures*/chemically induced , Drug Overdose* , Dose-Response Relationship, Drug* , Anticonvulsants*/poisoning , Anticonvulsants*/administration & dosage , Hypotension*/chemically induced, Humans ; Retrospective Studies ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Poison Control Centers/statistics & numerical data ; Coma/chemically induced ; Adolescent ; Aged |
| مستخلص: | Introduction: Carbamazepine causes dose-dependent toxicity in overdose. Resources commonly state that severe toxicity occurs with ingestions >50 mg/kg without supporting evidence. We aimed to compare ingested dose with clinical toxicity. Methods: This was a retrospective series of patients reportedly ingesting carbamazepine >2,000 mg referred to a clinical toxicology unit and state poisons information centre. Medical records were reviewed to extract patient demographics, ingestion details, clinical effects and management. Severe toxicity was defined as the presence of coma (Glasgow Coma Scale <9), seizure, or hypotension (systolic blood pressure <90 mmHg). Results: There were 69 presentations in 42 patients with a median ingested carbamazepine dose of 113 mg/kg (IQR: 71-151 mg/kg). Coma occurred in 10 cases, eight having ingested >200 mg/kg and the remaining two ingesting 113 mg/kg and 151 mg/kg, respectively. Seizures occurred in four cases (lowest ingested dose 143 mg/kg). Hypotension occurred in five cases (lowest ingested dose 113 mg/kg). Discussion: Severe carbamazepine toxicity did not occur with reported ingestions <100 mg/kg and was uncommon in ingestions <200 mg/kg. Conclusion: Severe toxicity was common in ingestions >200 mg/kg. Using the suggested threshold of severe toxicity of >50 mg/kg appeared overly conservative in this series. |
| فهرسة مساهمة: | Keywords: Carbamazepine; anti-convulsant; dose threshold; overdose; toxicity |
| المشرفين على المادة: | 33CM23913M (Carbamazepine) 0 (Anticonvulsants) |
| تواريخ الأحداث: | Date Created: 20240820 Date Completed: 20240820 Latest Revision: 20240820 |
| رمز التحديث: | 20240820 |
| DOI: | 10.1080/15563650.2024.2378091 |
| PMID: | 39163090 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1556-9519 |
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| DOI: | 10.1080/15563650.2024.2378091 |