دورية أكاديمية

COVID-19's Radiologic, Functional, and Serologic Consequences at 6-Month and 18-Month Follow-up: A Prospective Cohort Study.

التفاصيل البيبلوغرافية
العنوان: COVID-19's Radiologic, Functional, and Serologic Consequences at 6-Month and 18-Month Follow-up: A Prospective Cohort Study.
المؤلفون: Kim C; Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea., Seok H; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea., Kim J; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea., Park DW; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea., van Assen M; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Translational Laboratory for Cardiothoracic Imaging and Artificial Intelligence, Emory University School of Medicine, Atlanta, GA, USA., De Cecco CN; Translational Laboratory for Cardiothoracic Imaging and Artificial Intelligence, Emory University School of Medicine, Atlanta, GA, USA.; Division of Cardiothoracic Imaging, Department of Radiology, Emory University, Atlanta, GA, USA., Choi H; Medical Science Research Center, Korea University College of Medicine, Seoul, Korea., Kim C; Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea., Hwang SH; Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea., Yong HS; Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea., Oh YW; Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea., Choi WS; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea. cmcws@hanmail.net.
المصدر: Journal of Korean medical science [J Korean Med Sci] 2024 Aug 19; Vol. 39 (32), pp. e228. Date of Electronic Publication: 2024 Aug 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Korean Academy of Medical Science Country of Publication: Korea (South) NLM ID: 8703518 Publication Model: Electronic Cited Medium: Internet ISSN: 1598-6357 (Electronic) Linking ISSN: 10118934 NLM ISO Abbreviation: J Korean Med Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Seoul, Korea : Korean Academy of Medical Science, [1986-
مواضيع طبية MeSH: COVID-19*/diagnostic imaging , Tomography, X-Ray Computed* , Immunoglobulin G*/blood , SARS-CoV-2*/immunology , SARS-CoV-2*/isolation & purification , Respiratory Function Tests* , Lung*/diagnostic imaging , Lung*/pathology, Humans ; Male ; Female ; Prospective Studies ; Middle Aged ; Aged ; Follow-Up Studies ; Antibodies, Viral/blood ; Adult ; Forced Expiratory Volume ; Vital Capacity ; Risk Factors
مستخلص: Background: We evaluated the radiologic, pulmonary functional, and antibody statuses of coronavirus disease 2019 (COVID-19) patients 6 and 18 months after discharge, comparing changes in status and focusing on risk factors for residual computed tomography (CT) abnormalities.
Methods: This prospective cohort study was conducted on COVID-19 patients discharged between April 2020 and January 2021. Chest CT, pulmonary function testing (PFT), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) measurements were performed 6 and 18 months after discharge. We evaluated factors associated with residual CT abnormalities and the correlation between lesion volume in CT (lesion volume ), PFT, and IgG levels.
Results: This study included 68 and 42 participants evaluated 6 and 18 months, respectively, after hospitalizations for COVID-19. CT abnormalities were noted in 22 participants (32.4%) at 6 months and 13 participants (31.0%) at 18 months. Lesion volume was significantly lower at 18 months than 6 months ( P < 0.001). Patients with CT abnormalities at 6 months showed lower forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC), and patients with CT abnormalities at 18 months exhibited lower FVC. FVC significantly improved between 6 and 18 months of follow-up (all P < 0.0001). SARS-CoV-2 IgG levels were significantly higher in patients with CT abnormalities at 6 and 18 months ( P < 0.001). At 18-month follow-up assessments, age was associated with CT abnormalities (odds ratio, 1.17; 95% confidence interval, 1.03-1.32; P = 0.01), and lesion volume showed a positive correlation with IgG level ( r = 0.643, P < 0.001).
Conclusion: At 18-month follow-up assessments, 31.0% of participants exhibited residual CT abnormalities. Age and higher SARS-CoV-2 IgG levels were significant predictors, and FVC was related to abnormal CT findings at 18 months. Lesion volume and FVC improved between 6 and 18 months.
Trial Registration: Clinical Research Information Service Identifier: KCT0008573.
Competing Interests: The authors have no potential conflicts of interest to disclose.
(© 2024 The Korean Academy of Medical Sciences.)
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معلومات مُعتمدة: O2000831 Korea Korea Disease Control and Prevention Agency, Korea University Ansan Hospital; I2005491 Korea Sysmex Korea Company
فهرسة مساهمة: Keywords: COVID-19; Complications; Computed Tomography; Pulmonary Function Tests; Serologic Tests
المشرفين على المادة: 0 (Immunoglobulin G)
0 (Antibodies, Viral)
تواريخ الأحداث: Date Created: 20240820 Date Completed: 20240820 Latest Revision: 20240823
رمز التحديث: 20240823
مُعرف محوري في PubMed: PMC11333807
DOI: 10.3346/jkms.2024.39.e228
PMID: 39164053
قاعدة البيانات: MEDLINE
الوصف
تدمد:1598-6357
DOI:10.3346/jkms.2024.39.e228