The effect of inflammatory cytokines on the risk of hypertrophic scar: a mendelian randomization study.

التفاصيل البيبلوغرافية
العنوان:	The effect of inflammatory cytokines on the risk of hypertrophic scar: a mendelian randomization study.
المؤلفون:	Qi S; Shantou University, Guangdong Province, 515000, China., Ma A; Shantou University, Guangdong Province, 515000, China., Lin H; Shantou University, Guangdong Province, 515000, China., Peng L; Liupanshui Maternity and Child Health Care Hospital, Guizhou Province, 553000, China., Deng E; Shantou University, Guangdong Province, 515000, China. 22pqi@stu.edu.cn.
المصدر:	Archives of dermatological research [Arch Dermatol Res] 2024 Aug 21; Vol. 316 (8), pp. 551. Date of Electronic Publication: 2024 Aug 21.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin : Springer Verlag
مواضيع طبية MeSH:	Cicatrix, Hypertrophic/genetics , Cicatrix, Hypertrophic/epidemiology , Cicatrix, Hypertrophic/blood , Cicatrix, Hypertrophic/pathology , Mendelian Randomization Analysis* , Genome-Wide Association Study* , Leukemia Inhibitory Factor/genetics , Leukemia Inhibitory Factor/blood , Osteoprotegerin/genetics , Osteoprotegerin/blood, Humans ; Polymorphism, Single Nucleotide ; Glial Cell Line-Derived Neurotrophic Factor/genetics ; Cytokines/genetics ; Cytokines/blood ; Genetic Predisposition to Disease ; Risk Factors ; Male ; Female
مستخلص:	Hypertrophic scar (HS) results from burns or trauma, causing aesthetic and functional issues. However, observational studies have linked inflammatory cytokines to HS, but the causal pathways involved are unclear. We aimed to determine how circulating inflammatory cytokines contribute to HS formation. Two-sample Mendelian randomization (MR) was used to identify genetic variants associated with hypertrophic scar in a comprehensive, publicly available genome-wide association study (GWAS) involving 766 patients and 207,482 controls of European descent. Additionally, data on 91 plasma proteins were drawn from a GWAS summary involving 14,824 healthy participants. Causal relationships between exposures and outcomes were investigated primarily using the inverse variance weighted (IVW) method. Furthermore, a suite of sensitivity analyses, including MR‒Egger and weighted median approaches, were concurrently employed to fortify the robustness of the conclusive findings. Finally, reverse MR analysis was conducted to evaluate the plausibility of reverse causation between hypertrophic scar and the cytokines identified in our study. In inflammatory cytokines, there was evidence of inverse associations of osteoprotegerin(OPG) levels(OR = 0.59, 95% CI = 0.41 ∼ 0.85, p = 0.01), and leukemia inhibitory factor(LIF) levels(OR = 0.51, 95% CI = 0.32 ∼ 0.82, p = 0.01) are a nominally negative association with hypertrophic scar risk, while CUB domain-domain-containing protein 1(CDCP1) level(OR = 0.59, 95% CI = 0.41 ∼ 0.85, p = 0.01) glial cell line-derived neurotrophic factor(GDNF) levels(OR = 1.42, 95% CI = 1.03 ∼ 1.96, p = 0.01) and programmed cell death 1 ligand 1(PD-L1) levels(OR = 1.47, 95% CI = 1.92 ∼ 2.11, p = 0.04) showed a positive association with hypertrophic scar risk. These associations were similar in the sensitivity analyses. According to our MR findings, OPG and LIF have a protective effect on hypertrophic scar, while CDCP1, GDNF, and PD-L1 have a risk-increasing effect on Hypertrophic scar. Our study adds to the current knowledge on the role of specific inflammatory biomarker pathways in hypertrophic scar. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for hypertrophic scar prevention and treatment. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة:	Keywords: Genome-wide association study (GWAS); Hypertrophic scar; Inflammatory cytokines; Instrumental variable (IV); Mendelian randomization (MR)
المشرفين على المادة:	0 (Leukemia Inhibitory Factor) 0 (Osteoprotegerin) 0 (LIF protein, human) 0 (TNFRSF11B protein, human) 0 (GDNF protein, human) 0 (Glial Cell Line-Derived Neurotrophic Factor) 0 (Cytokines)
تواريخ الأحداث:	Date Created: 20240821 Date Completed: 20240821 Latest Revision: 20240821
رمز التحديث:	20240822
DOI:	10.1007/s00403-024-03303-7
PMID:	39167160
قاعدة البيانات:	MEDLINE

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تدمد:	1432-069X
DOI:	10.1007/s00403-024-03303-7