دورية أكاديمية
Clinical performance of Bladder EpiCheck™ versus voided urine cytology for detecting recurrence of nonmuscle invasive bladder cancer: Systematic review and meta-analysis.
| العنوان: | Clinical performance of Bladder EpiCheck™ versus voided urine cytology for detecting recurrence of nonmuscle invasive bladder cancer: Systematic review and meta-analysis. |
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| المؤلفون: | Chiang CH; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Boston, Massachusetts., Chang YC; Department of Medicine, Danbury Hospital, Danbury, Connecticut., Peng CY; Department of Medicine, Danbury Hospital, Danbury, Connecticut., Wang SS; Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York City, New York., Jaroenlapnopparat A; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Boston, Massachusetts., Wang JCH; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Jou CL; Department of Medical Education, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Tang PU; Department of Pediatrics, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Hsia YP; Department of Family Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. Electronic address: ustwhealth.datascience.group@gmail.com., Chiang CH; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan; London School of Hygiene and Tropical Medicine, London, UK., Chiang CH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. |
| المصدر: | Urologic oncology [Urol Oncol] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9805460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2496 (Electronic) Linking ISSN: 10781439 NLM ISO Abbreviation: Urol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Philadelphia, PA : Elsevier Original Publication: New York, NY : Elsevier Science, |
| مستخلص: | Background: Nonmuscle invasive bladder cancer (NMIBC) has a favorable prognosis but has high propensity for recurrence. Recent development in one of the urinary biomarker tests, Bladder EpiCheck™, offers a noninvasive and accurate method to detect NMIBC recurrence. In this study, we aimed to compare the diagnostic performance of Bladder EpiCheck™ with urine cytology to detect NMIBC recurrence. Methods: We performed a systematic review search through PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus from inception to July 2023. Diagnostic accuracy was defined by sensitivity, negative predictive value (NPV), specificity, and positive predictive value (PPV). Results: A total of 6 studies involving 1588 patients were included. Bladder EpiCheck™ has a sensitivity and specificity of 0.81 (95% CI: 0.63-0.91; I 2 : 43%) and 0.87 (95% CI: 0.83-0.91; I 2 : 20%), respectively. On the other hand, urine cytology has a sensitivity and specificity of 0.63 (95% CI: 0.29-0.87; I 2 : 61%) and 0.97 (95% CI: 0.78-1.00; I 2 : 79%), respectively. EpiCheck™ has a higher NPV (0.94 (95% CI: 0.87-0.97) vs. 0.84 (95% CI: 0.80-0.87) though a lower PPV (0.62 (95% CI: 0.45-0.76) vs. 0.87 (95% CI: 0.56-0.97) than urine cytology. In our subgroup analysis, the sensitivity of Bladder EpiCheck™ for detecting high-grade tumors improved to 0.90 (95% CI: 0.83-0.94) while that for urine cytology improved to 0.72 (95% CI: 0.50-0.87). Conclusion: Bladder EpiCheck™ has a high sensitivity and NPV for detecting recurrence among patients with NMIBC. Competing Interests: Declaration of competing interest No financial or personal conflicts of interest to declare. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bladder EpiCheck™; Bladder cancer; Surveillance; Urine cytology |
| تواريخ الأحداث: | Date Created: 20240821 Latest Revision: 20240821 |
| رمز التحديث: | 20240822 |
| DOI: | 10.1016/j.urolonc.2024.07.009 |
| PMID: | 39168785 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2496 |
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| DOI: | 10.1016/j.urolonc.2024.07.009 |