دورية أكاديمية
Optical Coherence Tomography Angiography Assessment of Optic Nerve Head and Macula across the Primary Angle Closure Disease Spectrum.
| العنوان: | Optical Coherence Tomography Angiography Assessment of Optic Nerve Head and Macula across the Primary Angle Closure Disease Spectrum. |
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| المؤلفون: | Tun TA; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Atalay E; Eskişehir Osmangazi University Medical School, Department of Ophthalmology, Turkey., Liu A; Amsterdam UMC, department of Ophthalmology, The Netherlands., Liu C; The Rotterdam Eye Hospital, Department of Glaucoma, The Netherlands., Aung T; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore., Nongpiur ME; Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.; Duke-NUS Medical School, Singapore. |
| المصدر: | Journal of glaucoma [J Glaucoma] 2024 Aug 23. Date of Electronic Publication: 2024 Aug 23. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc. Original Publication: New York, N.Y. : Raven Press, c1992- |
| مستخلص: | Prcis: The microvasculature of the optic disc and macula in eyes with acute primary angle closure and primary angle closure glaucoma was lower across the disease spectrum, but the significant difference was only observed in primary angle closure glaucoma. Purpose: To assess the microvasculature in the optic nerve head (ONH) and macula across primary angle-closure disease (PACD) spectrum using optical coherence tomography angiography (OCTA). Methods: OCTA (AngioVue, Fremont, CA) imaging was performed on 122 PACD subjects. Flow area (FA) and vessel density (VD) in the ONH, radial peripapillary capillary (RPC) network, and superficial and deep capillary plexuses of the macula were calculated and compared across the PACD spectrum using linear regression models with generalized estimating equations adjusted for inter-eye correlation. Results: A total of 234 eyes including 44 primary angle-closure suspects (PACS), 93 primary angle-closure (PAC), 79 primary angle-closure glaucoma (PACG) and 18 PAC with history of previous acute primary angle-closure (APAC) were included in the analysis. Compared to other groups, PACG eyes showed smaller FA in the ONH (1.35±0.02 mm2), RPC (0.78±0.03 mm2), and the superficial retinal layer (1.08±0.03 mm2) (all P<0.05). Lower VD was also observed in the "whole image", "inside disc", and "peripapillary" regions of the ONH and RPC, and the "whole image" and "parafoveal" regions of the retinal layer in the PACG group when compared with other groups (all P<0.05). No significant differences were found for the other groups (all P>0.05). Lower VD in the ONH, RPC, and superficial retinal layer significantly correlated with worse visual field loss in PACG eyes (all P<0.05). Conclusions: Significant reduction in the microvasculature of the optic disc and macula in PACG suggests that glaucoma development may contribute to lower VD in these regions. Competing Interests: Conflict of Interest: No conflicting relationship exists for any author. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20240822 Latest Revision: 20240822 |
| رمز التحديث: | 20240822 |
| DOI: | 10.1097/IJG.0000000000002488 |
| PMID: | 39171970 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-481X |
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| DOI: | 10.1097/IJG.0000000000002488 |