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Anticancer, antimicrobial and antioxidant activity of CuO-ZnO bimetallic nanoparticles: green synthesised from Eryngium foetidum leaf extract.

التفاصيل البيبلوغرافية
العنوان: Anticancer, antimicrobial and antioxidant activity of CuO-ZnO bimetallic nanoparticles: green synthesised from Eryngium foetidum leaf extract.
المؤلفون: Daimari J; Department of Chemistry, Central Institute of Technology Kokrajhar (Deemed to be University, under MoE, Govt. of India), Kokrajhar, Assam, 783370, India., Deka AK; Department of Chemistry, Central Institute of Technology Kokrajhar (Deemed to be University, under MoE, Govt. of India), Kokrajhar, Assam, 783370, India. a.kalita@cit.ac.in.
المصدر: Scientific reports [Sci Rep] 2024 Aug 22; Vol. 14 (1), pp. 19506. Date of Electronic Publication: 2024 Aug 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Copper*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Zinc Oxide*/chemistry , Zinc Oxide*/pharmacology , Plant Leaves*/chemistry , Metal Nanoparticles*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Green Chemistry Technology* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; MCF-7 Cells ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/chemical synthesis ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
مستخلص: In the present study, green synthetic pathway was adapted to synthesize CuO-ZnO bimetallic nanoparticles (BNPs) using Eryngium foetidum leaf extract and their anti-cancer activity against MCF7 breast cancer cell lines, anti-microbial activity and in vitro anti-oxidant activity were evaluated. Various bio-active compounds present in leaf extract were responsible for the reduction of CuO-ZnO NPs from respective Cu 2+ and Zn 2+ metal precursors. In the present study, the involvement of bio-active compounds present in E. foetidum extract before and after green synthesis of BNPs were evaluated for the first time. Rod-shaped and spherical structural morphology of synthesized BNPs were revealed by using FESEM, TEM, and XRD analysis with particle size ranged from 7 to 23 nm with an average size of 16.49 nm. The distribution of Cu and Zn were confirmed by elemental mapping. The green synthesized CuO-ZnO NPs showed significant cytotoxic effect with the inhibition rate 89.20 ± 0.03% at concentration of 500 μg/mL. Again, good antioxidant activity with IC 50; 0.253 mg/mL and antimicrobial activity of BNPs were also evaluated with the increasing order of MIC; E. coli (7.81 μg/mL) < B. subtilis (62.5 μg/mL) < S. aureus (31.25 μg/mL).
(© 2024. The Author(s).)
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معلومات مُعتمدة: 202122-NFST-ASS-00285 UGC New Delhi India
فهرسة مساهمة: Keywords: E. foetidum; Anticancer; Antimicrobial; Antioxidant; BNPs; Green synthesis
المشرفين على المادة: 789U1901C5 (Copper)
0 (Plant Extracts)
SOI2LOH54Z (Zinc Oxide)
0 (Antioxidants)
V1XJQ704R4 (cupric oxide)
0 (Antineoplastic Agents)
0 (Anti-Infective Agents)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240822 Date Completed: 20240822 Latest Revision: 20240822
رمز التحديث: 20240823
DOI: 10.1038/s41598-024-69847-w
PMID: 39174638
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-69847-w