دورية أكاديمية
أعرض في EDS

A nomogram including admission serum glycated albumin/albumin ratio to predict mortality in patients with severe fever with thrombocytopenia syndrome.

التفاصيل البيبلوغرافية
العنوان: A nomogram including admission serum glycated albumin/albumin ratio to predict mortality in patients with severe fever with thrombocytopenia syndrome.
المؤلفون: Wang L; Department of Clinical Laboratory, Qishan Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai, 264001, Shandong, The People's Republic of China. liliwang2200@163.com., Xie H; Department of Infectious disease, Qishan Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai, 264001, Shandong, The People's Republic of China., Liu Y; Department of Infectious disease, Qishan Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai, 264001, Shandong, The People's Republic of China., Zou Z; Department of Infectious disease, Qishan Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai, 264001, Shandong, The People's Republic of China.
المصدر: BMC infectious diseases [BMC Infect Dis] 2024 Aug 23; Vol. 24 (1), pp. 858. Date of Electronic Publication: 2024 Aug 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Nomograms* , Severe Fever with Thrombocytopenia Syndrome*/mortality , Severe Fever with Thrombocytopenia Syndrome*/blood , Severe Fever with Thrombocytopenia Syndrome*/virology , Serum Albumin*/analysis , Glycated Serum Albumin*, Humans ; Male ; Female ; Middle Aged ; Aged ; Retrospective Studies ; Prognosis ; Risk Factors ; Glycation End Products, Advanced/blood ; ROC Curve ; Adult ; Aged, 80 and over
مستخلص: Background: Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease with a high fatality rate. Although several nomograms based on demographic and laboratory data have been reported to predict the prognosis of SFTS in recent studies, baseline serum glycated albumin (GA)/albumin (ALB) ratio included risk model has not been evaluated for the prediction of clinical outcome.
Methods: A total of 214 SFTS patients with integral data admitted to our hospital from May, 2020 to November, 2022 were included in this study. SFTS infection was confirmed by real time fluorescent quantitative PCR (qRT-PCR). The demographic characteristics, clinical and laboratory data were collected with in 24 h of admission and 1 to 2 days before discharge and were analysed retrospectively.
Results: Fiffty-seven patients (26.6%) died. Multivariate logistic regression analysis showed that age, aspartate aminotransferase (AST), blood glucose (GLU), GA/ALB ratio, neutrophil counts (NEU) and lymphocyte percentage (LYM%) were the independent risk factors for mortality. A nomogram by these factors was created using RMS package in the R program. Area under the receiver operating characteristic (ROC) curve (AUC) of this nomogram was 0.88 (95% CI: 0.83, 0.93). This model showed the excellent net benefit, as revealed by the decision curve analysis. GA/ALB ratios were also independent risk factors for poor out clinical come in subgroups of patients with hyperglycemia on admission and with diabetes history. Nomograms were constructed by the independent risk factors in the subgroups. AUCs of the nomograms in the subgroups showed high predictive values for adverse prognosis.
Conclusions: GA/ALB ratios were independent risk factors for mortality in all SFTS patients and subgroups of with hyperglycemia on admission and diabetes history. The nomograms including GA/ALB ratio had high predictive value for adverse clinical outcome.The nomograms provide a basis for clinical decision-making for the treatment of SFTS patients in different clinical settings.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Clinical outcome; Glycated albumin/albumin ratio; Nomogram; Prediction; Severe fever with thrombocytopenia syndrome
المشرفين على المادة: 0 (Serum Albumin)
0 (Glycated Serum Albumin)
0 (Glycation End Products, Advanced)
تواريخ الأحداث: Date Created: 20240823 Date Completed: 20240823 Latest Revision: 20240826
رمز التحديث: 20240827
مُعرف محوري في PubMed: PMC11342538
DOI: 10.1186/s12879-024-09752-9
PMID: 39179974
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-024-09752-9