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Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain.

التفاصيل البيبلوغرافية
العنوان: Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain.
المؤلفون: Zuniga NR; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Earls NE; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Denos AEA; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Elison JM; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Jones BS; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Smith EG; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Moran NG; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Brown KL; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Romero GM; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Hyer CD; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Wagstaff KB; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Almughamsi HM; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA.; Department of Chemistry, College of Science, Taif University, Taif, Saudi Arabia., Transtrum MK; Department of Physics and Astronomy, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA., Price JC; Department of Chemistry and Biochemistry, College of Computational, Physical, and Mathematical Sciences, Brigham Young University, Provo, UT, USA.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 14. Date of Electronic Publication: 2024 Aug 14.
نوع المنشور: Journal Article; Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Apolipoprotein E (ApoE) polymorphisms modify the risk of neurodegenerative disease with the ApoE4 isoform increasing and ApoE2 isoform decreasing risk relative to the 'wild-type control' ApoE3 isoform. To elucidate how ApoE isoforms alter the proteome, we measured relative protein abundance and turnover in transgenic mice expressing a human ApoE gene (isoform 2, 3, or 4). This data provides insight into how ApoE isoforms affect the in vivo synthesis and degradation of a wide variety of proteins. We identified 4849 proteins and tested for ApoE isoform-dependent changes in the homeostatic regulation of ~2700 ontologies. In the brain, we found that ApoE4 and ApoE2 both lead to modified regulation of mitochondrial membrane proteins relative to the wild-type control ApoE3. In ApoE4 mice, this regulation is not cohesive suggesting that aerobic respiration is impacted by proteasomal and autophagic dysregulation. ApoE2 mice exhibited a matching change in mitochondrial matrix proteins and the membrane which suggests coordinated maintenance of the entire organelle. In the liver, we did not observe these changes suggesting that the ApoE-effect on proteostasis is amplified in the brain relative to other tissues. Our findings underscore the utility of combining protein abundance and turnover rates to decipher proteome regulatory mechanisms and their potential role in biology.
References: J Proteome Res. 2019 Jun 7;18(6):2632-2642. (PMID: 31055927)
J Neurochem. 2013 Jan;124(1):4-14. (PMID: 22862561)
J Mol Biol. 2020 Mar 27;432(7):2349-2368. (PMID: 32105731)
Nature. 2005 Jan 6;433(7021):77-83. (PMID: 15635413)
Mol Cell Neurosci. 2013 Jul;55:26-36. (PMID: 22922446)
J Alzheimers Dis. 2017;57(4):1265-1279. (PMID: 28372324)
Annu Rev Cell Dev Biol. 2000;16:19-49. (PMID: 11031229)
J Proteome Res. 2022 Nov 4;21(11):2703-2714. (PMID: 36099490)
Trends Neurosci. 2021 Feb;44(2):136-151. (PMID: 33160650)
Nat Rev Genet. 2020 Oct;21(10):630-644. (PMID: 32709985)
Elife. 2018 Oct 30;7:. (PMID: 30375977)
Mol Neurodegener. 2009 Aug 20;4:35. (PMID: 19695092)
Anal Biochem. 2012 Jan 1;420(1):73-83. (PMID: 21964502)
Cell Rep. 2023 Oct 31;42(10):113183. (PMID: 37777962)
Cell Syst. 2017 Sep 27;5(3):283-294.e5. (PMID: 28918244)
J Biol Chem. 2002 Jun 14;277(24):21821-8. (PMID: 11912196)
Neuron. 2018 Jun 27;98(6):1141-1154.e7. (PMID: 29861287)
Mol Neurodegener. 2019 Dec 26;14(1):50. (PMID: 31878951)
JAMA. 1997 Oct 22-29;278(16):1349-56. (PMID: 9343467)
Behav Genet. 2017 Jul;47(4):416-424. (PMID: 28337631)
Mol Cell. 2013 May 9;50(3):368-78. (PMID: 23583076)
Antioxid Redox Signal. 2016 Dec 1;25(16):886-901. (PMID: 27392670)
Bioinformatics. 2017 May 15;33(10):1514-1520. (PMID: 28093409)
Mol Cell Proteomics. 2024 Jul;23(7):100791. (PMID: 38797438)
Behav Brain Res. 2016 May 15;305:37-45. (PMID: 26892275)
J Lipid Res. 1982 Nov;23(8):1224-35. (PMID: 7175379)
Nucleic Acids Res. 2021 Jan 8;49(D1):D1541-D1547. (PMID: 33174596)
BMC Genomics. 2006 Jun 08;7:142. (PMID: 16762068)
Cell. 2022 Jun 23;185(13):2213-2233.e25. (PMID: 35750033)
Neuron. 2023 Jun 21;111(12):1898-1913.e5. (PMID: 37040764)
Mol Cell Proteomics. 2020 Jul;19(7):1088-1103. (PMID: 32312845)
Stem Cell Reports. 2022 Jan 11;17(1):110-126. (PMID: 34919811)
J Biol Chem. 2004 Dec 31;279(53):55483-92. (PMID: 15485881)
Sci Rep. 2020 Mar 9;10(1):4277. (PMID: 32152337)
Biology (Basel). 2021 Jun 29;10(7):. (PMID: 34209580)
Mol Neurodegener. 2017 Dec 22;12(1):89. (PMID: 29273078)
Aging (Albany NY). 2019 Dec 6;11(23):11148-11156. (PMID: 31808750)
Cell Death Dis. 2020 Jul 24;11(7):578. (PMID: 32709881)
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):12011-6. (PMID: 20547867)
Mol Neurodegener. 2021 Sep 6;16(1):62. (PMID: 34488832)
J Lipid Res. 2017 Sep;58(9):1884-1892. (PMID: 28743728)
Cell Rep. 2016 Sep 13;16(11):3041-3051. (PMID: 27626671)
Med Res Rev. 2018 Sep;38(6):1916-1973. (PMID: 29719055)
Pharmacol Res. 2021 Jan;163:105248. (PMID: 33065283)
Nat Rev Neurol. 2013 Feb;9(2):106-18. (PMID: 23296339)
Nat Methods. 2020 Mar;17(3):261-272. (PMID: 32015543)
Cells. 2023 Jan 25;12(3):. (PMID: 36766752)
Nat Rev Mol Cell Biol. 2018 Nov;19(11):713-730. (PMID: 30143745)
J Cell Sci. 2022 Jan 15;135(2):. (PMID: 34982109)
EMBO J. 2012 Nov 5;31(21):4106-23. (PMID: 22892566)
J Alzheimers Dis. 2019;68(3):991-1011. (PMID: 30883359)
Neurobiol Dis. 2002 Apr;9(3):305-18. (PMID: 11950276)
Front Neurosci. 2017 Dec 12;11:702. (PMID: 29311783)
Cell. 2016 Oct 20;167(3):803-815.e21. (PMID: 27720452)
J Neurosci. 2009 Jul 15;29(28):9090-103. (PMID: 19605646)
IUBMB Life. 2014 Sep;66(9):616-23. (PMID: 25328986)
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14508-13. (PMID: 20699386)
Neurology. 2004 Jun 22;62(12):2198-202. (PMID: 15210882)
J Neurosci. 2018 Jul 25;38(30):6665-6681. (PMID: 29967007)
J Neurosci. 2005 Mar 16;25(11):2803-10. (PMID: 15772340)
Eur J Neurosci. 2023 Mar;57(6):1033-1047. (PMID: 36775930)
Sci Signal. 2010 Dec 07;3(151):ra88. (PMID: 21139140)
J Alzheimers Dis. 2010;22(1):307-13. (PMID: 20847408)
Brief Funct Genomic Proteomic. 2005 Feb;3(4):382-90. (PMID: 15814028)
J Cell Biol. 2021 Jun 7;220(6):. (PMID: 33950241)
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2231-2232. (PMID: 32451547)
Mol Cell Proteomics. 2021;20:100016. (PMID: 33556866)
J Cell Mol Med. 2009 Aug;13(8B):1632-1643. (PMID: 19432818)
Nat Commun. 2014 Dec 18;5:5585. (PMID: 25519239)
Prog Mol Biol Transl Sci. 2012;108:51-74. (PMID: 22656373)
Anal Biochem. 2011 Jul 15;414(2):173-8. (PMID: 21459075)
Cell. 2004 Jan 23;116(2):153-66. (PMID: 14744428)
J Neurosci. 2016 Jan 20;36(3):685-700. (PMID: 26791201)
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450. (PMID: 30395289)
Mol Cell Proteomics. 2017 Feb;16(2):243-254. (PMID: 27932527)
EBioMedicine. 2020 Sep;59:102954. (PMID: 32818802)
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243)
Acta Neuropathol Commun. 2015 Nov 10;3:70. (PMID: 26556230)
Mol Omics. 2020 Dec 1;16(6):573-582. (PMID: 32968743)
Neuronal Signal. 2019 Jun;3(2):NS20180203. (PMID: 32269835)
Neuron. 2011 Jun 23;70(6):1033-53. (PMID: 21689593)
Genes Nutr. 2014 May;9(3):397. (PMID: 24671632)
Antioxidants (Basel). 2020 Jun 25;9(6):. (PMID: 32630431)
Cells. 2022 Dec 10;11(24):. (PMID: 36552756)
Mol Cell Proteomics. 2017 Sep;16(9):1621-1633. (PMID: 28679685)
Curr Opin Cell Biol. 2016 Aug;41:33-42. (PMID: 27062547)
Cell Rep. 2020 Oct 6;33(1):108224. (PMID: 33027662)
J Appl Physiol (1985). 2020 May 1;128(5):1163-1176. (PMID: 32213116)
Oxid Med Cell Longev. 2021 Mar 25;2021:6634181. (PMID: 33833851)
Int J Mol Sci. 2015 Aug 17;16(8):19458-76. (PMID: 26287188)
Neurobiol Aging. 2008 Nov;29(11):1607-18. (PMID: 17544172)
Nat Commun. 2018 Mar 15;9(1):1097. (PMID: 29545515)
Mol Cell Proteomics. 2012 Dec;11(12):1551-65. (PMID: 23125033)
Atherosclerosis. 1996 Oct 25;126(2):177-84. (PMID: 8902143)
STAR Protoc. 2021 Mar 18;2(1):100377. (PMID: 33786460)
Stress. 2015;18(4):419-26. (PMID: 25938810)
Neurobiol Dis. 2020 Mar;136:104742. (PMID: 31931141)
PeerJ. 2020 Feb 20;8:e8638. (PMID: 32117642)
Nature. 2011 May 19;473(7347):337-42. (PMID: 21593866)
Cell. 2012 Dec 21;151(7):1528-41. (PMID: 23260140)
Elife. 2016 Jan 08;5:e13027. (PMID: 26744777)
Elife. 2018 Jun 19;7:. (PMID: 29914620)
Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1305-15. (PMID: 27174096)
Transl Psychiatry. 2021 Oct 5;11(1):507. (PMID: 34611141)
Mol Cell Proteomics. 2012 Dec;11(12):1801-14. (PMID: 22984287)
Curr Opin Neurobiol. 2023 Apr;79:102684. (PMID: 36753858)
Cell Rep. 2021 Jan 5;34(1):108572. (PMID: 33406436)
J Biol Chem. 2009 Oct 2;284(40):27273-80. (PMID: 19666463)
FEBS Lett. 2017 Sep;591(17):2648-2660. (PMID: 28696498)
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6037-42. (PMID: 10811879)
Front Neurosci. 2021 Feb 17;15:630502. (PMID: 33679311)
Biochim Biophys Acta Proteins Proteom. 2020 Aug;1868(8):140428. (PMID: 32305689)
معلومات مُعتمدة: R01 AG066874 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Alzheimer’s Disease; Amyloidβ; ApoE; Endosome; Isotope Labeling; Mitochondria; Neurodegeneration; Proteasome; Proteomics
تواريخ الأحداث: Date Created: 20240826 Latest Revision: 20240830
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC11343127
DOI: 10.1101/2024.08.13.607719
PMID: 39185235
قاعدة البيانات: MEDLINE
الوصف
تدمد:2692-8205
DOI:10.1101/2024.08.13.607719