دورية أكاديمية
MMP13 Expression and Activity Suggest Its Role in Bone Resorption in Ameloblastomas.
| العنوان: | MMP13 Expression and Activity Suggest Its Role in Bone Resorption in Ameloblastomas. |
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| المؤلفون: | Valeriano AT; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Camara LS; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Bernardes VF; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Pais FS; René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz Minas), Belo Horizonte, MG, Brazil., Araújo FMG; René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz Minas), Belo Horizonte, MG, Brazil., Salim ACM; René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz Minas), Belo Horizonte, MG, Brazil., Fernandes GDR; René Rachou Institute, Oswaldo Cruz Foundation (Fiocruz Minas), Belo Horizonte, MG, Brazil., Stussi F; Biological Sciences Institute, Universidade Federal de minas Gerais, Belo Horizonte, MG, Brazil., Gomes CC; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., de Andrade Santos PP; Department of Morphology, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil., de Souza LB; Department of Oral Pathology, Universidade Federal do Rio Grande do Norte (UFRN), Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Gomez RS; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG) and Medical School, Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil., Diniz MG; Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. |
| المصدر: | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8911934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0714 (Electronic) Linking ISSN: 09042512 NLM ISO Abbreviation: J Oral Pathol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Wiley-Blackwell Original Publication: Copenhagen : Munksgaard, c1989- |
| مستخلص: | Background: Ameloblastoma is a locally destructive benign odontogenic tumor. While the neoplastic cells of conventional ameloblastoma can infiltrate the connective tissue and bone, in unicystic ameloblastoma the epithelium is encapsulated. The mechanisms driving ameloblastoma's bone resorption remains unclear. Methods: RNA sequencing (RNA-seq) was performed in a discovery cohort of conventional ameloblastoma, and pathway enrichment analysis was carried out. mRNA levels of MMP13, a gene associated with bone resorption, were assessed using RT-qPCR in a larger cohort of conventional ameloblastoma and in unicystic ameloblastoma. Zymogram gels and the immunoexpression profile of collagenase 3 (encoded by MMP13 gene) were evaluated as well. Results: Enriched pathways related to bone mineralization and upregulation of MMP13 were observed in ameloblastomas. Collagenolytic activity of collagenase 3 was detected in the tumor lysates. Collagenase 3 immunopositivity was observed in ameloblastomatous epithelium infiltrating the fibrous capsule of unicystic ameloblastoma. At the tumor-bone interface, collagenase 3 expression was detected in stromal cells, osteoblasts, and osteocytes. Conclusion: The results indicate a potential involvement of MMP13 in ameloblastoma-related bone resorption and progression. (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| فهرسة مساهمة: | Keywords: ameloblastoma; bone resorption; collagenase 3; matrix metalloproteinase 13; odontogenic tumor |
| تواريخ الأحداث: | Date Created: 20240828 Latest Revision: 20240828 |
| رمز التحديث: | 20240828 |
| DOI: | 10.1111/jop.13577 |
| PMID: | 39192690 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-0714 |
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| DOI: | 10.1111/jop.13577 |