Six transmembrane epithelial antigens of the prostate to illustrate inflammatory response in gastrointestinal cancers.

التفاصيل البيبلوغرافية
العنوان:	Six transmembrane epithelial antigens of the prostate to illustrate inflammatory response in gastrointestinal cancers.
المؤلفون:	Wu YH; The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China., Luo LX; The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn.
المصدر:	World journal of clinical oncology [World J Clin Oncol] 2024 Aug 24; Vol. 15 (8), pp. 961-964.
نوع المنشور:	Editorial
اللغة:	English
بيانات الدورية:	Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101549149 Publication Model: Print Cited Medium: Print ISSN: 2218-4333 (Print) Linking ISSN: 22184333 NLM ISO Abbreviation: World J Clin Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Publication: 2014-: Pleasanton, CA : Baishideng Publishing Group Original Publication: Hong Kong : Baishideng Publishing Group
مستخلص:	Gastrointestinal cancer (GIC) is a common and widespread form of tumor, with colonoscopy and upper gastrointestinal endoscopy available to detect relevant precancerous polyps and lesions. However, many patients are already in the late stages when first diagnosed with such cancer, resulting in a poor prognosis. Thus, it is necessary to explore new methods and research directions in order to improve the treatment of GIC. Given the specific nature of the gastrointestinal tract, research should focus on the mechanisms of various inflammations and the interactions between food entering and exiting from the gastrointestinal tract and cancer cells. Interestingly, six transmembrane epithelial antigens of the prostates (STEAPs) have been found to be significantly linked to the progression of malignant tumors, associated with intracellular oxidative stress and playing a major role in inflammation with their structure and function. This paper explores the mechanism of STEAPs in the inflammatory response of GIC, providing a theoretical basis for the prevention and early intervention of GIC. The basic properties of the STEAP family as metal reductase are also explained. When it comes to intervention for GIC prevention, STEAPs can affect the activity of Fe ³⁺ , Cu ²⁺ reductase and regulate metal ion uptake in vivo , participating in inflammation-related iron and copper homeostasis. Thus, the mechanism of STEAPs on inflammation is of important value in the prevention of GIC. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
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فهرسة مساهمة:	Keywords: Colorectal cancer; Gastric cancer; Gastrointestinal cancer; Hepatocellular carcinoma; Inflammation; Six transmembrane epithelial antigens of the prostate
تواريخ الأحداث:	Date Created: 20240828 Latest Revision: 20240829
رمز التحديث:	20240830
مُعرف محوري في PubMed:	PMC11346062
DOI:	10.5306/wjco.v15.i8.961
PMID:	39193158
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	2218-4333
DOI:	10.5306/wjco.v15.i8.961