دورية أكاديمية
أعرض في EDS

Effects of long-term metformin administration associated with high-intensity interval training on physical performance, glycogen concentration, GLUT-4 content, and NMR-based metabolomics in healthy rats.

التفاصيل البيبلوغرافية
العنوان: Effects of long-term metformin administration associated with high-intensity interval training on physical performance, glycogen concentration, GLUT-4 content, and NMR-based metabolomics in healthy rats.
المؤلفون: Bastos-Silva VJ; Laboratório de Ciências Aplicadas ao Esporte, Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil.; Grupo de Pesquisa Aplicada ao Desempenho e Saúde, Centro Universitário CESMAC, Maceió, AL, Brasil., Spineli H; Laboratório de Ciências Aplicadas ao Esporte, Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Guimarães JC; Laboratório de Ciências Aplicadas ao Esporte, Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Borbely KSC; Laboratório de Biologia Celular, Instituto de Biologia e Ciências da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Ursulino JS; Núcleo de Análise e Pesquisa em Ressonância Magnética Nuclear, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brasil., Aquino TM; Núcleo de Análise e Pesquisa em Ressonância Magnética Nuclear, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brasil., Bento ES; Núcleo de Análise e Pesquisa em Ressonância Magnética Nuclear, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brasil., Scariot PPM; Laboratório de Fisiologia Aplicada ao Esporte, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Campinas, SP, Brasil., Sousa FAB; Laboratório de Ciências Aplicadas ao Esporte, Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Araujo GG; Laboratório de Ciências Aplicadas ao Esporte, Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil.
المصدر: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2024 Aug 23; Vol. 57, pp. e13276. Date of Electronic Publication: 2024 Aug 23 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: eCollection Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981-
مواضيع طبية MeSH: Glucose Transporter Type 4*/metabolism , Glycogen*/metabolism , Glycogen*/analysis , High-Intensity Interval Training*/methods , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/administration & dosage , Metabolomics* , Metformin*/pharmacology , Metformin*/administration & dosage , Physical Conditioning, Animal*/physiology, Animals ; Male ; Rats ; Magnetic Resonance Spectroscopy/methods ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Physical Functional Performance ; Random Allocation ; Rats, Wistar ; Time Factors
مستخلص: The aim was to investigate the long-term effects of metformin ingestion on high-intensity interval training on performance, glycogen concentration (GC), GLUT-4 content, and metabolomics outcomes in rats. Fifty male Wistar rats were randomly divided into baseline, metformin (500 mg daily), and control groups. Training consisted of 4 sets of 10 jumps with 30 s of passive recovery per day, 5 days/week for 8 weeks. The intensity equivalent was 50% of body mass (BM) in the first four weeks and 70% of BM in the last four weeks. The animals were submitted to a weekly jump test until exhaustion at 50% of BM. Serum and tissues were collected at baseline and after 4 and 8 weeks for biochemical and metabolomics analysis. The number of jumps increased in the Control group without a significant difference between groups at 4 and 8 weeks. GLUT4 was lower in the gastrocnemius muscle in the Metformin at the fourth week compared to Control (P=0.03) and compared to Metformin (P=0.02) and Control (P=0.01) at eight weeks. Hepatic and soleus GC were not altered by metformin. Gastrocnemius GC was lower after 8 weeks in the Metformin group compared to Control (P=0.01). Significantly lower levels of pyruvate and phenylalanine and higher levels of ethanol, formate, betaine, very low-density lipoprotein, low-density lipoprotein, and creatine were found in the Metformin compared to the Control. Although chronic administration of metformin decreased food intake and negatively influenced the synthesis of muscle glycogen, it did not significantly change physical performance compared to the Control.
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المشرفين على المادة: 0 (Glucose Transporter Type 4)
9005-79-2 (Glycogen)
0 (Hypoglycemic Agents)
9100L32L2N (Metformin)
تواريخ الأحداث: Date Created: 20240828 Date Completed: 20240828 Latest Revision: 20240830
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC11349150
DOI: 10.1590/1414-431X2024e13276
PMID: 39194030
قاعدة البيانات: MEDLINE
الوصف
تدمد:1414-431X
DOI:10.1590/1414-431X2024e13276