دورية أكاديمية
أعرض في EDS

Monoclonal Gammopathy of Undetermined Significance and Associated Cardiovascular Outcomes in a Hospital Setting-A Fresh Perspective.

التفاصيل البيبلوغرافية
العنوان: Monoclonal Gammopathy of Undetermined Significance and Associated Cardiovascular Outcomes in a Hospital Setting-A Fresh Perspective.
المؤلفون: Mustafa A; Department of Cardiology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Wei C; Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Araji G; Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Niazi MRK; Department of Hematology and Oncology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Grovu R; Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Weinberg M; Department of Cardiology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Lafferty J; Department of Cardiology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA.
المصدر: Current oncology (Toronto, Ont.) [Curr Oncol] 2024 Aug 01; Vol. 31 (8), pp. 4432-4442. Date of Electronic Publication: 2024 Aug 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : Basel, Switzerland : MDPI
Original Publication: Toronto : Multimed, c1994-
مواضيع طبية MeSH: Monoclonal Gammopathy of Undetermined Significance*/complications , Cardiovascular Diseases*/epidemiology, Humans ; Female ; Male ; Aged ; Middle Aged ; Comorbidity ; Hospitalization/statistics & numerical data ; Aged, 80 and over
مستخلص: There is a paucity of data on the cardiovascular implications of monoclonal gammopathy of undetermined significance, especially among hospitalized patients. Our study aimed to investigate the association between MGUS and cardiovascular outcomes in a hospital setting using the National Inpatient Sample database. MGUS patients were sampled using ICD-10 codes. The patients were stratified into two cohorts based on the presence or absence of MGUS. Comorbidities and cardiovascular outcomes were collected using ICD 10 DM codes. CV outcomes were evaluated before and after 1:1 matching for age, gender, and race. Furthermore, a sensitivity analysis was performed on the matched population, which excluded patients with diabetes mellitus, prior myocardial infarction, chronic kidney disease (stages 3-5), dialysis, hypertension, obesity, metabolic syndrome, cancer, antiplatelets, and oral anticoagulant use and was adjusted for smoking, dyslipidemia, and aspirin use to evaluate the cardiovascular outcomes. MGUS patients had more heart failure, atrial fibrillation, venous thromboembolism, aortic aneurysm, aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, conduction disorder, cor pulmonale, peripheral vascular disease, and acute myocardial infarction. After matching, MGUS was associated with heart failure, atrial fibrillation, venous thromboembolism, aortic stenosis, mitral regurgitation, conduction disorder, cor pulmonale, and peripheral vascular disease. MGUS was linked to a wide spectrum of cardiovascular diseases in an inpatient setting. Further studies are needed to formulate appropriate recommendations for the screening and management of cardiovascular complications in individuals with MGUS.
References: Bone Marrow Transplant. 2018 Jul;53(7):895-899. (PMID: 29367711)
N Engl J Med. 1998 Apr 23;338(17):1169-73. (PMID: 9554856)
J Cardiovasc Dev Dis. 2023 Dec 04;10(12):. (PMID: 38132652)
N Engl J Med. 2002 Feb 21;346(8):564-9. (PMID: 11856795)
N Engl J Med. 2017 Jul 13;377(2):111-121. (PMID: 28636844)
Clin Lymphoma Myeloma Leuk. 2018 Sep;18(9):e345-e350. (PMID: 29980412)
Blood. 2008 Nov 1;112(9):3582-6. (PMID: 18559977)
Am J Cardiol. 2019 Oct 15;124(8):1190-1197. (PMID: 31395298)
Exp Mol Pathol. 2008 Jun;84(3):213-7. (PMID: 18417124)
J Clin Oncol. 1987 Dec;5(12):1998-2003. (PMID: 3681381)
Leukemia. 2004 Sep;18(9):1555-7. (PMID: 15241438)
Klin Onkol. 2018 Summer;31(4):270-276. (PMID: 30541309)
Blood. 1972 Nov;40(5):719-24. (PMID: 4627911)
Blood. 2006 Feb 1;107(3):904-6. (PMID: 16210333)
Cardiovasc Res. 2012 Apr 1;94(1):105-14. (PMID: 22298642)
Blood. 2010 Jun 17;115(24):4991-8. (PMID: 20299513)
Am J Cardiol. 2014 Oct 15;114(8):1243-8. (PMID: 25260814)
Blood. 2018 Jan 11;131(2):163-173. (PMID: 29183887)
Cancer. 2004 Aug 1;101(3):558-66. (PMID: 15274069)
JACC CardioOncol. 2022 Sep 20;4(3):323-325. (PMID: 36213348)
Ann Oncol. 2004 Oct;15(10):1490-4. (PMID: 15367409)
Eur J Haematol. 2011 Feb;86(2):129-34. (PMID: 20942842)
Cardiology. 2000;93(4):220-8. (PMID: 11025347)
Lancet Haematol. 2014 Oct 1;1(1):e28-e36. (PMID: 25530988)
J Rheumatol. 1988 Apr;15(4):556-60. (PMID: 3397965)
Ann Hematol. 2017 Apr;96(4):695-696. (PMID: 28058489)
Mayo Clin Proc. 2009 Aug;84(8):685-93. (PMID: 19648385)
Blood. 2005 Aug 1;106(3):812-7. (PMID: 15855274)
Br J Haematol. 2001 Feb;112(2):353-7. (PMID: 11167828)
Haematologica. 2009 Dec;94(12):1714-20. (PMID: 19608666)
Br J Haematol. 2020 Jun;189(6):1127-1135. (PMID: 31999849)
Cancer Treat Res. 2016;169:3-12. (PMID: 27696254)
JNCI Cancer Spectr. 2019 Dec 16;4(2):pkz104. (PMID: 33336146)
Cancers (Basel). 2021 Mar 22;13(6):. (PMID: 33810169)
Clin Adv Hematol Oncol. 2009 Dec;7(12):827-32. (PMID: 20332755)
Neoplasma. 2020 Jul;67(4):939-945. (PMID: 32567936)
Clin Lymphoma Myeloma. 2007 Jul;7(7):462-6. (PMID: 17875234)
Blood Cancer J. 2021 May 17;11(5):94. (PMID: 34001889)
BBA Clin. 2016 May 25;6:12-8. (PMID: 27331023)
Thromb Res. 2001 Jun 15;102(6):V215-24. (PMID: 11516455)
Br J Haematol. 2004 Sep;126(5):686-9. (PMID: 15327520)
Blood. 2006 Apr 15;107(8):3378-83. (PMID: 16397135)
Int J Cardiol. 2013 Jul 1;166(3):702-8. (PMID: 22178057)
Thromb Res. 2010 Mar;125(3):216-9. (PMID: 19193398)
Ann Hematol. 2019 Oct;98(10):2431-2432. (PMID: 31432215)
J Hosp Med. 2015 Apr;10(4):228-35. (PMID: 25627860)
Cardiol J. 2022;29(2):216-227. (PMID: 32329041)
JACC CardioOncol. 2022 Jul 19;4(3):313-322. (PMID: 36213365)
فهرسة مساهمة: Keywords: MGUS; cardiovascular comorbidities; cardiovascular diseases; cardiovascular outcomes; non-cardiovascular comorbidities
تواريخ الأحداث: Date Created: 20240828 Date Completed: 20240828 Latest Revision: 20240830
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC11352401
DOI: 10.3390/curroncol31080331
PMID: 39195314
قاعدة البيانات: MEDLINE
الوصف
تدمد:1718-7729
DOI:10.3390/curroncol31080331