دورية أكاديمية
Monoclonal Gammopathy of Undetermined Significance and Associated Cardiovascular Outcomes in a Hospital Setting-A Fresh Perspective.
العنوان: | Monoclonal Gammopathy of Undetermined Significance and Associated Cardiovascular Outcomes in a Hospital Setting-A Fresh Perspective. |
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المؤلفون: | Mustafa A; Department of Cardiology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Wei C; Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Araji G; Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Niazi MRK; Department of Hematology and Oncology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Grovu R; Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Weinberg M; Department of Cardiology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA., Lafferty J; Department of Cardiology, Northwell Health/Staten Island University Hospital, Staten Island, New York, NY 10305, USA. |
المصدر: | Current oncology (Toronto, Ont.) [Curr Oncol] 2024 Aug 01; Vol. 31 (8), pp. 4432-4442. Date of Electronic Publication: 2024 Aug 01. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2021- : Basel, Switzerland : MDPI Original Publication: Toronto : Multimed, c1994- |
مواضيع طبية MeSH: | Monoclonal Gammopathy of Undetermined Significance*/complications , Cardiovascular Diseases*/epidemiology, Humans ; Female ; Male ; Aged ; Middle Aged ; Comorbidity ; Hospitalization/statistics & numerical data ; Aged, 80 and over |
مستخلص: | There is a paucity of data on the cardiovascular implications of monoclonal gammopathy of undetermined significance, especially among hospitalized patients. Our study aimed to investigate the association between MGUS and cardiovascular outcomes in a hospital setting using the National Inpatient Sample database. MGUS patients were sampled using ICD-10 codes. The patients were stratified into two cohorts based on the presence or absence of MGUS. Comorbidities and cardiovascular outcomes were collected using ICD 10 DM codes. CV outcomes were evaluated before and after 1:1 matching for age, gender, and race. Furthermore, a sensitivity analysis was performed on the matched population, which excluded patients with diabetes mellitus, prior myocardial infarction, chronic kidney disease (stages 3-5), dialysis, hypertension, obesity, metabolic syndrome, cancer, antiplatelets, and oral anticoagulant use and was adjusted for smoking, dyslipidemia, and aspirin use to evaluate the cardiovascular outcomes. MGUS patients had more heart failure, atrial fibrillation, venous thromboembolism, aortic aneurysm, aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, conduction disorder, cor pulmonale, peripheral vascular disease, and acute myocardial infarction. After matching, MGUS was associated with heart failure, atrial fibrillation, venous thromboembolism, aortic stenosis, mitral regurgitation, conduction disorder, cor pulmonale, and peripheral vascular disease. MGUS was linked to a wide spectrum of cardiovascular diseases in an inpatient setting. Further studies are needed to formulate appropriate recommendations for the screening and management of cardiovascular complications in individuals with MGUS. |
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فهرسة مساهمة: | Keywords: MGUS; cardiovascular comorbidities; cardiovascular diseases; cardiovascular outcomes; non-cardiovascular comorbidities |
تواريخ الأحداث: | Date Created: 20240828 Date Completed: 20240828 Latest Revision: 20240830 |
رمز التحديث: | 20240830 |
مُعرف محوري في PubMed: | PMC11352401 |
DOI: | 10.3390/curroncol31080331 |
PMID: | 39195314 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1718-7729 |
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DOI: | 10.3390/curroncol31080331 |